DDoS Hide & Seek:On the effectiveness of a booter services takedown

Booter services continue to provide popular DDoS-as-a-service platforms and enable anyone irrespective of their technical ability, to execute DDoS attacks with devastating impact. Since booters are a serious threat to Internet operations and can cause significant financial and reputational damage, they also draw the attention of law enforcement agencies and related counter activities. In this paper, we investigate booter-based DDoS attacks in the wild and the impact of an FBI takedown targeting 15 booter websites in December 2018 from the perspective of a major IXP and two ISPs. We study and compare attack properties of multiple booter services by launching Gbps-level attacks against our own infrastructure. To understand spatial and temporal trends of the DDoS traffic originating from booters we scrutinize 5 months, worth of inter-domain traffic. We observe that the takedown only leads to a temporary reduction in attack traffic. Additionally, one booter was found to quickly continue operation by using a new domain for its website

Afinidade de seis variedades cítricas sobre porta enxerto de limão rugoso nacional (Citrus limon).

bitstream/item/152687/1/ComTec46.pd

Proposta para avaliação das frações de carbono no solo em forma de carvão presente em solos do Cerrado.

Os objetivos desse trabalho são ajustar metodologia de extração do carvão presente no solo e quantificar os estoques de C na forma de carvão em diferentes localidades e profundidades em solos do Cerrado e sua contribuição de carbono total no solo

Induction of Epithelial Mesenchimal Transition and Vasculogenesis in the Lenses of Dbl Oncogene Transgenic Mice

BACKGROUND: The Dbl family of proteins represents a large group of proto-oncogenes involved in cell growth regulation. The numerous domains that are present in many Dbl family proteins suggest that they act to integrate multiple inputs in complicated signaling networks involving the Rho GTPases. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders and neoplastic transformation. We generated transgenic mice introducing the cDNA of Dbl oncogene linked to the metallothionein promoter into the germ line of FVB mice and found that onco-Dbl expression in mouse lenses affected proliferation, migration and differentiation of lens epithelial cells. RESULTS: We used high density oligonucleotide microarray to define the transcriptional profile induced by Dbl in the lenses of 2 days, 2 weeks, and 6 weeks old transgenic mice. We observed modulation of genes encoding proteins promoting epithelial-mesenchymal transition (EMT), such as down-regulation of epithelial cell markers and up-regulation of fibroblast markers. Genes encoding proteins involved in the positive regulation of apoptosis were markedly down regulated while anti-apoptotic genes were strongly up-regulated. Finally, several genes encoding proteins involved in the process of angiogenesis were up-regulated. These observations were validated by histological and immunohistochemical examination of the transgenic lenses where vascularization can be readily observed. CONCLUSION: Onco-Dbl expression in mouse lens correlated with modulation of genes involved in the regulation of EMT, apoptosis and vasculogenesis leading to disruption of the lens architecture, epithelial cell proliferation, and aberrant angiogenesis. We conclude that onco-Dbl has a potentially important, previously unreported, capacity to dramatically alter epithelial cell migration, replication, polarization and differentiation and to induce vascularization of an epithelial tissue