Bioadsorption of CI Reactive Blue 203 dye by duckweed Lemna gibba’s powder

: Many contaminants, especially dyes used to manufacture paint, textiles, and other products, are released into the aquatic environment as a result of human population increase and industrialization. In this study, it was chosen to develop a plant biomaterial compatible with the demand of the world market in cost terms, and to focus on the reuse of powder duckweed Lemna gibba as a new effective material for the removal of dyes in particular, considering this plant's capacity for purification even in the waste state after assisting a lagoon plant achieve phytoremediation. After analyzing the effects of pH, contact time, adsorbate concentration, and adsorbent dosage on the dye (CI Reactive Blue 203)'s adsorption process on the plant powder Lemna gibba, it was determined that the adsorption kinetics follows the pseudo first order model and the adsorption isotherm is best described by the Langmuir model, and that the percentage of dye removal reaches 90% at pH 3 of the solution, and the adsorption capacity reaches its maximum of 96% at only 0.5g of the powder and 25 mL of the solution. As a result, this study recommends using powder Lemna gibba plant as an alternative for activated carbon in adsorption

Natural products and synthetic analogs as a source of antitumor drugs

Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural products as a source of antitumor drugs.This work was supported by CONICYT PIA/APOYO CCTE AFB170007

Anticancer and anti-inflammatory effects of tomentosin: Cellular and molecular mechanisms

Tomentosin is a natural compound known for its presence in some medicinal plants of the Asteraceae family such as Inula viscosa. Recent studies have highlighted its anticancer and anti-inflammatory properties. Its anticancer mechanisms are unique and act at different levels ranging from cellular organization to molecular transcriptional factors and epigenetic modifications. Tomentosin’s possession of the modulatory effect on telomerase expression on tumor cell lines has captured the interest of researchers and spurred a more robust study on its anticancer effect. Since inflammation has a close link with cancer disease, this natural compound appears to be a potential cancer-fighting drug. Indeed, its recently demonstrated anti-inflammatory action can be considered as a starting point for its evaluation as an anticancer chemo-preventive agent

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules

Polymorphism of HLA and Susceptibility of Breast Cancer

Breast cancer (BC) is the second most common malignancy in the world. Numerous studies have demonstrated the association between human leukocyte antigen (HLA) and cancer. The occurrence and development of BC are closely linked to genetic factors. Human leukocyte antigens G and E (HLA-G and HLA-E) are non-classical major histocompatibility complex (MHC) class I molecules. These molecules play an important role in immune surveillance by inhibiting the cytotoxic and natural killer T cells responsible for immune escape. The expression of HLA-G and HLA-E has been associated with several diseases, including tumors. The HLA system plays a key role in the escape of tumor cells from immune surveillance. This review aims to determine the correlation between BC susceptibility and HLA markers specific HLA alleles such as HLA-B07, HLA-DRB111, HLA-DRB113, and HLA-DRB115 are associated with an increased risk of developing BC. Furthermore, HLA-G mutations have been attributed to an elevated likelihood of metastasis in BC patients. Understanding the complex associations between the HLA system and BC development is critical for developing novel cancer prevention, detection, and treatment strategies. This review emphasizes the importance of analyzing HLA polymorphisms in the management of BC patients, as well as the urgent need for further research in this area

Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies

The regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for DNA demethylation at the CpG islands, particularly at the promoter regions, to regulate transcription. The aberrant activity of these enzymes, i.e. their abnormal expression or activity, can result in the repression or overactivation of gene expression. Consequently, this can generate cellular dysregulation leading to instability and tumor development. Several reports highlighted the involvement of DNMTs in human cancers. The inhibition or activation of DNMTs is a promising therapeutic approach in many human cancers. In the present work, we provide a comprehensive and critical summary of natural bioactive molecules as primary inhibitors of DNMTs in human cancers. The active compounds hold the potential to be developed as anti-cancer epidrugs targeting DNMTs

Les nutrithérapies sont-elles efficaces contre les maladies du cancer ?

Le cancer est une maladie complexe dont les facteurs de risque sont multiples, les stades évolutifs sont très variés et les mécanismes de transformation sont extrêmement interconnectés et désormais déchiffrés. La complexité résulte de l’altération de l’expression des séquences oncogéniques et des gènes suppresseurs de tumeurs. La transformation tumorale a besoin du passage d’une cellule d’un état somatique ou germinal à un état anarchique dont leur division devient incontrôlable. Le développement des thérapies ne permettrait désormais de cibler spécifiquement les cellules cancéreuses sans altérer d’autres cellules normales. Les composés d’origines naturelles sont montrés capables de surmonter ces échecs thérapeutiques.