Tidal damping of the mutual inclination in hierachical systems

Hierarchical two-planet systems, in which the inner body's semi-major axis is between 0.1 and 0.5 AU, usually present high eccentricity values, at least for one of the orbits. As a result of the formation process, one may expect that planetary systems with high eccentricities also have high mutual inclinations. However, here we show that tidal effects combined with gravitational interactions damp the initial mutual inclination to modest values in timescales that are shorter than the age of the system. This effect is not a direct consequence of tides on the orbits, but it results from a secular forcing of the inner planet's flattening. We then conclude that these hierarchical planetary systems are unlikely to present very high mutual inclinations, at least as long as the orbits remain outside the Lidov-Kozai libration areas. The present study can also be extended to systems of binary stars and to planet-satellite systems.Comment: 16 pages, 13 figure

Arrival angle anomalies of Rayleigh waves observed at a broadband array: a systematic study based on earthquake data, full waveform simulations and noise correlations

Deviation of seismic surface waves from the great-circle between source and receiver is illustrated by the anomalies in the arrival angle, that is the difference between the observed backazimuth of the incident waves and the great-circle. Such arrival angle anomalies have been known for decades, but observations remain scattered. We present a systematic study of arrival angle anomalies of fundamental mode Rayleigh waves (20–100 s period interval) from 289 earthquakes and recorded by a broadband network LAPNET, located in northern Finland. These observations are compared with those of full waveform synthetic seismograms for the same events, calculated in a 3-D Earth and also compared with those of seismograms obtained by ambient noise correlation. The arrival angle anomalies for individual events are complex, and have significant variations with period. On average, the mean absolute deviation decreases from ∼9° at 20 s period to ∼3° at 100 s period. The synthetic seismograms show the same evolution, albeit with somewhat smaller deviations. While the arrival angle anomalies are fairly well simulated at long periods, the deviations at short periods are very poorly modelled, demonstrating the importance of the continuous improvement of global crustal models. At 20–30 s period, both event data and numerical simulations have strong multipathing, and relative amplitude changes between different waves will induced differences in deviations between very closely located events. The source mechanism has only limited influence on the deviations, demonstrating that they are directly linked to propagation effects, including near-field effects in the source area. This observation is confirmed by the comparison with seismic noise correlation records, that is where the surface waves correspond to those emitted by a point source at the surface, as the two types of observations are remarkably similar in the cases where earthquakes are located close to seismic stations. This agreement additionally confirms that the noise correlations capture the complex surface wave propagation

A new analysis of the WASP-3 system: no evidence for an additional companion

In this work we investigate the problem concerning the presence of additional bodies gravitationally bounded with the WASP-3 system. We present eight new transits of this planet and analyse all the photometric and radial velocity data published so far. We did not observe significant periodicities in the Fourier spectrum of the observed minus calculated (O-C) transit timing and radial velocity diagrams (the highest peak having false-alarm probabilities of 56 per cent and 31 per cent, respectively) or long-term trends. Combining all the available information, we conclude that the radial velocity and transit timing techniques exclude, at 99 per cent confidence limit, any perturber more massive than M \gtrsim 100 M_Earth with periods up to 10 times the period of the inner planet. We also investigate the possible presence of an exomoon on this system and determined that considering the scatter of the O-C transit timing residuals a coplanar exomoon would likely produce detectable transits. This hypothesis is however apparently ruled out by observations conducted by other researchers. In case the orbit of the moon is not coplanar the accuracy of our transit timing and transit duration measurements prevents any significant statement. Interestingly, on the basis of our reanalysis of SOPHIE data we noted that WASP-3 passed from a less active (log R'_hk=-4.95) to a more active (log R'_hk=-4.8) state during the 3 yr monitoring period spanned by the observations. Despite no clear spot crossing has been reported for this system, this analysis claims for a more intensive monitoring of the activity level of this star in order to understand its impact on photometric and radial velocity measurements.Comment: MNRAS accepted (14/08/2012

Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature

International audienceBackground. There are few data on anakinra use after failure of conventional medications for crystal-induced peripheral arthritis and/or crowned dens syndrome among complex hospitalized patients. Methods. We retrospectively analyzed the outcome of six patients affected with subacute crystal-induced arthritis who had received anakinra in second or third line therapy, including three patients with crowned dens syndrome and three others with gouty arthritis. Patients' comorbidities, reasons for anakinra use and associated drugs, and outcomes were recorded. Results. All patients presented with elevated inflammatory syndrome, systemic symptoms with poly/oligoarthritis. Except for absolute contraindications, all patients were previously treated with full or decreased dose of NSAID, colchicine, and/or glucocorticoids, with unsatisfactory response. All three gouty patients exhibited complete responses in all acute involvements under anakinra within 3 to 5 days, including one of them who needed the reintroduction of colchicine treatment that was previously unsuccessful. Crowned dens syndrome patients, including two with pseudogout and one with subacute hydroxyapatite deposition disease, needed 9 to 11 days to achieve complete response. Tolerance to anakinra was good. Conclusion. In case series of complex hospitalized patients, anakinra showed good activity in crowned dens syndrome and associated crystal-induced peripheral arthritis, with longer treatment duration than in gouty arthritis

The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos

Abstract The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and bioactive lipids. Although both pathways are key regulators of kidney physiology and linked to human renal pathologies, their roles during nephrogenesis remain poorly understood. We previously showed that the pronephros was a major site of enpp expression and now demonstrate an unsuspected role for the conserved vertebrate enpp4 protein during kidney formation in Xenopus . Enpp4 over-expression results in ectopic renal tissues and, on rare occasion, complete mini-duplication of the entire kidney. Enpp4 is required and sufficient for pronephric markers expression and regulates the expression of RA, Notch and Wnt pathway members. Enpp4 is a membrane protein that binds, without hydrolyzing, phosphatidylserine and its effects are mediated by the receptor s1pr5, although not via the generation of S1P. Finally, we propose a novel and non-catalytic mechanism by which lipidic signalling regulates nephrogenesis

Environment, human reproduction, menopause, and andropause.

As the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator is an integrator of hormonal, metabolic, and neural signals, it is not surprising that the function of the hypothalamogonadal axis is subject to the influence of a large array of environmental factors. Before puberty, the central nervous system (CNS) restrains the GnRH pulse generator. Undernutrition, low socioeconomic status, stress, and emotional deprivation, all delay puberty. During reproductive life, among peripheral factors that effect the reproductive system, stress plays an important role. Stress, via the release of corticotropin-releasing factor (CRF), eventually triggered by interleukin 1, inhibits GnRH release, resulting in hypogonadism. Effects of CRF are probably mediated by the opioid system. Food restriction and underweight (anorexia nervosa), obesity, smoking, and alcohol all have negative effects on the GnRH pulse generator and gonadal function. Age and diet are important determinants of fertility in both men and women. The age-associated decrease in fertility in women has as a major determinant chromosomal abnormalities of the oocyte, with uterine factors playing a subsidiary role. Age at menopause, determined by ovarian oocyte depletion, is influenced by occupation, age at menarche, parity, age at last pregnancy, altitude, smoking, and use of oral contraceptives. Smoking, however, appears to be the major determinant. Premature menopause is most frequently attributable to mosaicism for Turner Syndrome, mumps ovaritis, and, above all, total hysterectomy, which has a prevalence of about 12-15% in women 50 years old. Premature ovarian failure with presence of immature follicles is most frequently caused by autoimmune diseases or is the consequence of irradiation or chemotherapy with alkylating cytostatics. Plasma estrogens have a physiological role in the prevention of osteoporosis. Obese women have osteoporosis less frequently than women who are not overweight. Early menopause, suppression of adrenal function (corticoids), and thyroid hormone treatment all increase the frequency of osteoporosis. Aging in men is accompanied by decreased Leydig cell and Sertoli cell function, which has a predominantly primary testicular origin, although changes also occur at the hypothalamopituitary level. Plasma testosterone levels, sperm production, and sperm quality decrease, but fertility, although declining, is preserved until senescence. Stress and disease states accelerate the decline on Leydig cell function. Many occupational noxious agents have a negative effect on fertility.(ABSTRACT TRUNCATED AT 400 WORDS

Harmonizing methods for wildlife abundance estimation and pathogen detection in Europe-a questionnaire survey on three selected host-pathogen combinations

__Background:__ The need for wildlife health surveillance as part of disease control in wildlife, domestic animals and humans on the global level is widely recognized. However, the objectives, methods and intensity of existing wildlife health surveillance programs vary greatly among European countries, resulting in a patchwork of data that are difficult to merge and compare. This survey aimed at evaluating the need and potential for data harmonization in wildlife health in Europe. The specific objective was to collect information on methods currently used to estimate host abundance and pathogen prevalence. Questionnaires were designed t

High spatial resolution analysis of ferromanganese concretions by LA-ICP-MS†

A procedure was developed for the determination of element distributions in cross-sections of ferromanganese concretions using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The effects of carrier flow rates, rf forward power, ablation energy, ablation spot size, repetition rate and number of shots per point on analyte intensity were studied. It is shown that different carrier gas flow rates are required in order to obtain maximum sensitivities for different groups of elements, thus complicating the optimisation of ICP parameters. On the contrary, LA parameters have very similar effects on almost all elements studied, thus providing a common optimum parameter set for the entire mass range. However, for selected LA parameters, the use of compromise conditions was necessary in order to compensate for relatively slow data acquisition by ICP-MS and maintain high spatial resolution without sacrificing the multielemental capabilities of the technique. Possible variations in ablation efficiency were corrected for mathematically using the sum of Fe and Mn intensities. Quantification by external calibration against matrix-matched standards was successfully used for more than 50 elements. These standards, in the form of pressed pellets (no binder), were prepared in-house using ferromanganese concentrates from a deep-sea nodule reference material as well as from shallow-marine concretions varying in size and having different proportions of three major phases: aluminosilicates, Fe- and Mn-oxyhydroxides. Element concentrations in each standard were determined by means of conventional solution nebulisation ICP-MS following acid digestion. Examples of selected inter-element correlations in distribution patterns along the cross-section of a concretion are given