Clinical outcomes and response to treatment of patients receiving topical treatments for pyoderma gangrenosum: a prospective cohort study

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. Objective: to estimate the effectiveness of topical therapies in the treatment of PG. Methods: prospective cohort study of UK secondary care patients with a clinical diagnosis of PG suitable for topical treatment (recruited July 2009 to June 2012). Participants received topical therapy following normal clinical practice (mainly Class I-III topical corticosteroids, tacrolimus 0.03% or 0.1%). Primary outcome: speed of healing at 6 weeks. Secondary outcomes: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality-of-life; treatment failure and recurrence. Results: Sixty-six patients (22 to 85 years) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28/66 (43.8%) of ulcers healed by 6 months. Median time-to-healing was 145 days (95% CI: 96 days, ∞). Initial ulcer size was a significant predictor of time-to-healing (hazard ratio 0.94 (0.88;80 1.00); p = 0.043). Four patients (15%) had a recurrence. Limitations: No randomised comparator Conclusion: Topical therapy is potentially an effective first-line treatment for PG that avoids possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone

ICRF antenna matching systems with ferrite tuners for the Alcator C-Mod tokamak

Real-time fast ferrite tuning (FFT) has been successfully implemented on the ICRF antennas on Alcator C-Mod. The former prototypical FFT system on the E-port 2-strap antenna has been upgraded using new ferrite tuners. A new FFT system with two ferrite tuners and one fixed-length stub has been installed on the transmission line of the D-port 2-strap antenna. These two systems are able to achieve and maintain the reflected power to the transmitters to less than 1% in real time under almost all plasma conditions and help ensure reliable high power operation of the antennas. The loading insensitivity feature vs. plasma conditions of the innovative field-aligned (FA) 4-strap antenna on the J-port allows us to significantly improve the matching by installing a carefully designed stub on each of the two transmission lines. The reduction of the RF voltages in the transmission lines has enabled the J-port FA antenna to deliver 3.7 MW RF power to plasmas out of 4 MW source power. The matching on the J-port antenna can be further improved by adding a single ferrite tuner under real-time control on each transmission line and this scheme will be implemented in the near future.United States. Department of Energy (Agreement DE-FC02-99ER54512

An intermediate power amplifier upgrade for 40 to 80 Mhz for the alcator C-mod ICRF transmitters

ICRF operations with Alcator C-Mod consists of 4 transmitters, of which two are tunable within the 40 MHz to 80 MHz band. These transmitters were comprised of 3 stages all of which employed vacuum tube amplifiers. As a part of the general plan to upgrade the two tunable transmitters, a project was implemented to replace the first stage, the intermediate power amplifier, with a 10 kilowatt solid state broadband amplifier. There were two primary benefits from the upgrade. The tuning of the transmitters was considerably simplified and better performance was obtained under a variety of operational conditions by having a conservative power margin. The improvements obtained are an important first step toward advancing the overall radio frequency performance of the transmitters and minimizing the time intensive task of changing the frequency of operation.United States. Dept. of Energy (Cooperative Grant No. DE-FC02-99ER54512-C-Mod

Upgrade of the ICRF fault and control systems on alcator C-mod

The Ion Cyclotron RF Transmitter System (ICRF) at Alcator C-Mod comprises four separate transmitters each capable of driving 2 MW of power into plasma loads. Four separate transmission lines guide RF power into three antennas, each mounted in a separate horizontal port, in the C-Mod Tokamak. Protection for the antennas, matching elements and transmission line is accomplished by two unique but interdependent subsystems encompassed by the ICRF Fault System. The Antenna Protection System evaluates antenna phasing and voltage, sets fault thresholds, generates fault signals, and passes fault information to the Master Fault Processor. During operation, the Master Fault Processor is responsible for detecting hazards along the transmission line, generating faults, processing faults from the Antenna Protection System, terminating RF drive and extinguishing faults within 10 mus. In addition, the system controls various delays and sets the boundaries for RF retries. The ICRF Control System provides amplitude regulation for all antennas and phase control for a four-strap antenna. We are modifying some of the fault processing components and control elements of these systems in an effort to improve reliability and serviceability, and increase flexibility. This upgrade will reduce wired interconnections, add remote features to improve access to key operating parameters, improve RF isolation with new switching components, simplify phase control, and expand the RF regulation system to an active control regime whereby plasma parameters may become direct feedback elements for RF regulation. Details of the proposed upgrade to the system will be presented, and implementation of any new technological tools will be discussed.United States. Dept of Energy (Cooperative Grant No. DE-FC02-99ER54512-C-Mod