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A Summer Camp in Engineering Physics for Incoming Freshman to Improve Retention and Student Success

Summer camps have proven to be a valuable tool to attract and recruit students interested in pursuing a career in the STEM field. They have been also used to spark their curiosity in areas like mathematics. However, these camps do not help with issues that appear after the student has been admitted at the university. It is well known that many students are shocked when they transition from high-school to college. Many of them do not know how to handle their academic freedom; they start without any friends, and they do not know the campus and the resources available. By realizing this situation a 1-week resident summer camp for incoming freshman has been created at . The goal of this is camp is to help them with their transition from high-school to college. During the summer camp, they review concepts related to Math and Science, they are introduced to the campus and resources available, and they meet other students who are also interested in pursuing a career in the STEM field. The students stay at the dormitories located in campus; they eat in the cafeteria, and they collaborate with the professors in classroom and laboratory settings

Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses

Lenalidomide has particular activity in patients with transfusion-dependent del(5q) myelodysplastic syndromes (MDS), but mechanistic information is limited regarding the relationship between erythroid and cytogenetic responses. We reviewed medical records from three distinct subgroups of del(5q) MDS patients who had unexpected effects with lenalidomide treatment: 1. two patients with complex karyotypes who achieved both cytogenetic remissions and transfusion independence; 2. two patients with 5q- syndrome who took lenalidomide for less than 12 weeks but remained transfusion independent for 15+ months still displaying del(5q) metaphases after 6 and 12 months; and 3. one patient who was a non-responder on lenalidomide during treatment but became transfusion independent for 13+ months after discontinuation. All but the latter patient in this series had reduction of affected metaphases, suggesting that erythroid responses might be mediated by result from partial or complete suppression of the malignant clone, either directly or indirectly through modulation of the bone marrow microenvironment. These clinical observations illustrate the heterogeneity of del(5q)MDS pathogenesis and the diversity of lenalidomide responses within this patient subset

Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload

Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), including the management of transfusional iron overload with iron chelation therapy. Guidelines have been developed by The Italian Society of Hematology, The UK MDS Guidelines Group, The Nagasaki Group, The National Comprehensive Cancer Network, and The MDS Foundation. These guidelines show that the approaches to managing iron overload in patients with MDS are region specific, differing in their recommendations for when iron chelation therapy should be initiated and strategies for the ongoing management of iron overload. The guidelines all agree that red blood cell transfusions are clinically beneficial to treat the symptomatic anemia in MDS, and that patients with low-risk MDS receiving transfusions are the most likely to benefit from iron chelation therapy

Platelet counts and haemorrhagic diathesis in patients with myelodysplastic syndromes.

Most patients with myelodysplastic syndromes (MDS) present with single or multiple lineage cytopenias in peripheral blood despite a hypercellular bone marrow. Thrombocytopenia, attributable to ineffective platelet production by dysfunctional megakaryocytes, has been estimated to occur in 40-65% of patients. However, there are hardly any studies on the clinical relevance of low platelet counts in MDS. We retrospectively analysed data from 2900 patients in the Duesseldorf MDS Registry who were diagnosed at our laboratory between 1982 and 2007. At the time of diagnosis, 43% of the patients had a platelet count lower than 100 000/microL. Platelets were lower than 20 000/microL in 7% of the patients, especially in those with advanced stages of MDS, who showed a higher frequency of thrombocytopenia and platelet transfusion dependency. On multivariate analysis, platelet anisometry, hypocellularity of megakaryopoiesis, maturational defects of megakaryocytes and platelets <20 000/microL were independent variables showing a statistically significant correlation (P < 0.05) with clinical signs of bleeding. Platelets lower than 100 000/microL were associated with significantly shortened survival (P < 0.00005), because of an increased risk of progression to acute myeloid leukaemia (AML) (30% vs. 21%) (P < 0.02) and bleeding (16% vs. 8%) (P = 0.0005). Thrombocytopenia is a strong predictor of short survival, with or without haemorrhagic complications

Analysis of Mechanical Safety of Stadiums for the World Cup 2018

It is obvious that contemporary design and construction of unique buildings and structures is unthinkable without mathematical (numerical) and computer modelling and advanced analysis ofload-bearing structures under various kinds ofloads and impacts. One of the most ambitious and important construction projects is the uniquelarge-span structures. These are, in particular, stadiums, sports palaces and water parks, shopping malls, pedestrian, road and railway bridges of various design solutions. The distinctive paper is devoted to theoretical foundations and results of mathematical (numerical) modeling of the state (in terms of the analysis of stress-strain state, strength and stability) of football stadiums built for the 2018 FIFA World Cup in Russia. Finite element method is used for approximation and high-precision numerical solution of corresponding boundary problems of structural mechanics. It is the most universal and powerful numerical method of mechanics. The paper, in particular, describes some features of development of finite element models and the main results of the analysis of the mechanical (structural) safety of three- dimensionallarge-span systems "soil foundation - reinforced concrete structures of foundations and stands - steel structures of the coating and facades" of these football stadiums with the basic and specialload combinations. In addition, the key procedures of scientific support during the corresponding expertise and assessments are outlined. Generally, socially significant and knowledge-intensive problem of providing mechanical (constructive) safety of unique combined objects of construction (three-dimensional systems "foundation - reinforced concrete structures of foundations and stands - steel structures of coating and facades") has been solved at a new level as a result of the performed complex of research works