Stigma for mental illness among primary health care physicians and nurses in Dammam, Saudi Arabia

ABSTRACT: People who experience any type of mental disorder not only face difficulties with their health challenge they also suffered from negative responses that come from their social environment in many forms such as discrimination, denial or social rejection and this leads to stigma. Mental illness stigmatization within the healthcare professional has an impact on the delivery and provision of care services to the patients and is an obstacle to health seeking and maintaining good health management. This study aims to explore stigma for mental disorder in primary health care physicians and nurses because they are the first contact when a patient needs help. The study took place in Dammam Primary Health Centres and recruited physicians and nurses who completed the Opening Mind Scale for Health Care Providers as a tool of measuring levels of stigma. The results of the questionnaire were compared between both groups and correlated with their sociodemographic data. Result prove the existence of stigma in primary health physician and nurses the mean score is 55.13 out of 100. with Saudi staff having more stigma than non- Saudi , another factor that associated with more stigma is gender as female express more stigma than male . At the end of the study stigma in physicians and nurses was almost equal. This needs to be considered in future planning to minimize negative perception of people with a mental illness by initiating anti-stigmatization program for health care provider as a means of primary prevention and health promotion

Fibrinogen concentrate for treatment of bleeding and surgical prophylaxis in congenital fibrinogen deficiency patients

Background: Congenital fibrinogen deficiency is an ultra-rare disorder in which patients can experience severe and/or frequent bleeding episodes (BEs). Here, we present the largest prospective study to date on the treatment of this disorder. Methods: Hemostatic efficacy of human fibrinogen concentrate (HFC; FIBRYGA\uae, Octapharma AG) for treatment of bleeding or surgical prophylaxis was assessed by investigators and adjudicated by an independent data monitoring and endpoint adjudication committee (IDMEAC) according to a four-point scale, using objective criteria. Thromboelastometry maximum clot firmness (MCF) was also determined. Results: Twenty-five afibrinogenemia patients were treated with HFC: 24 for on-demand treatment of 89 BEs, and nine as prophylaxis for 12 surgeries. For BEs, treatment success (rating of excellent or good) evaluated by investigators was 96.6% (90% confidence interval [CI], 0.92-0.99; two missing ratings, classified as failures) and by the IDMEAC was 98.9% (90% CI, 0.95-0.999). Mean \ub1 standard deviation (SD) increase in MCF was 5.8 \ub1 2.5 mm one hour after the first HFC infusion (mean \ub1 SD dose, 61.88 \ub1 11.73 mg/kg). For the 12 surgeries (median [range] HFC dose/surgery, 85.80 mg/kg [34.09-225.36]), intraoperative and postoperative treatment success were both rated 100% (90% CI, 0.82-1.00) by investigators and the IDMEAC. Three adverse events were possibly treatment related, including a moderate case of thrombosis. There were no deaths, no severe allergic or hypersensitivity reactions, and no clinical evidence of neutralizing antifibrinogen antibodies. Conclusions: Human fibrinogen concentrate was efficacious for on-demand treatment of bleeding and as surgical prophylaxis, with a favorable safety profile, in patients with congenital afibrinogenemia

The Current Issues on Osteoporosis among Male Saudi Arabians

Background and Objective: Osteoporosis was reported to be common among Saudi Arabian population. In the last decade there have been no reports related to the male osteoporosis in Saudi Arabian citizens. The objective of this study was to find the hospital-based prevalence of male osteoporosis among Saudi Arabians. Methodology: This is the retrospective study between January 2014 and December 2016 in which all patients who were referred for DEXA (Dual Energy X ray Absorptiometry) scan to the radiology department of the King Fahd Hospital of the University, AlKhobar. Patient’s demographic data was collected from the medical records. Patients who were younger than 50 years and those who had a fragility fracture were excluded from the analysis. From the IPAC the readings of the DEXA were collected. Associated diseases of the patients were also extracted from the QuadruMed Data Base. The data was entered in the database and analyzed using SPSS Inc. version 19 and p value of <0.05 was considered significant. Results: Four hundred and fifty five patients had a DEXA scan during the study period. Three hundred and seventy one (81.5%) were ≥50 years. The average was 65.33±9.85 years (Range 50-97). On the basis of Spinal T score, 222 (59.8%) were osteoporotic with the spinal T score of <-3.58±0.88, while with hip T score 120 (32.3%) were osteoporotic with T score of <-3.24±0.59. Thirty-six (9.7%) had a normal DEXA of spine and 74(19.9%) of patients had normal DEXA when Hip was taken into consideration. Patients could be divided into four groups based on their diseases; they were on treatment for Cardiac disease 106 (28.5%), Diabetes mellitus 95 (25.7%), osteoarthritis 141 (38%) and Respiratory Disease 29 (7.8%). Based on the Spinal T score osteoporosis was observed in 61/106 (57.5%) patients with cardiac disease, 62/95 (65.3%) Diabetics, in osteoarthritis 83/141 (58.9%) and 16/29 (55.1%) in patients with respiratory system diseases. Majority of the patients had vitamin D3 analysis and were most of the patients were in the deficiency range. From 222 (59.83%) patients who were diagnosed to have osteoporosis only 108 (48.64%) were on appropriate treatment for osteoporosis. Conclusion: In conclusion this study finds that prevalence of osteoporosis in Saudi Arabian males have increased in the last decade, We believe more determined attempts to be encouraged to early screen, and report their observation to come to a consensus about the prevalence of male osteoporosis and implement appropriate measures to limit the further rise in the prevalence of osteoporosis among the male population of Saudi Arabia

A Facile Synthesis and Molecular Characterization of Certain New Anti-Proliferative Indole-Based Chemical Entities

Cancer cells frequently develop drug resistance, which leads to chemotherapeutic treatment failure. Additionally, chemotherapies are hindered by their high toxicity. Therefore, the development of new chemotherapeutic drugs with improved clinical outcomes and low toxicity is a major priority. Several indole derivatives exhibit distinctive anti-cancer mechanisms which have been associated with various molecular targets. In this study, target compounds 4a–q were obtained through the reaction of substituted benzyl chloride with hydrazine hydrate, which produces benzyl hydrazine. Subsequently, the appropriate substituted benzyl hydrazine was allowed to react with 1H-indole-2-carboxylic acid or 5-methoxy-1H-indole-2-carboxylic acid using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as a coupling agent. All compounds exhibited cytotoxicity in three cell lines, namely, MCF-7, A549, and HCT. Compound 4e exhibited the highest cytotoxicity, with an average IC50 of 2 µM. Moreover, a flow cytometry study revealed a significantly increased prevalence of Annexin-V and 7-AAD positive cell populations. Several derivatives of 4a–q showed moderate to high cytotoxicity against the tested cell lines, with compound 4e having the highest cytotoxicity, indicating that it may possess potential apoptosis-inducing capabilities

Novel Metoprolol-Loaded Chitosan-Coated Deformable Liposomes in Thermosensitive In Situ Gels for the Management of Glaucoma: A Repurposing Approach

Glaucoma is a long-term eye disease associated with high intraocular pressure (IOP), which seriously damages the eyes, causing blindness. For successful therapy, potent drugs and delivery systems are required. Metoprolol (MT) is believed to help reduce elevated IOP. The paradigm of ocular therapeutics may be changed by the integration of chitosan-coated liposomes (CLPs) with thermosensitive in situ gel (ISG). Therefore, MT-CLPs were developed and characterized and compared to uncoated ones (MT-LPs). Furthermore, MT-LP- and MT-CLP-loaded ISGs were prepared and characterized in in vitro, ex vivo, and in vivo studies. MT-LPs and MT-CLPs displayed spherical shapes with nanosize range, reasonable EE%, and significant bioadhesion. The zeta potential changed from negative to positive after CS coating. The extended in vitro drug release of MT-CLPs showed significant mucin mucoadhesion. The formed ISGs were homogeneous with a pH range of 7.34 to 7.08 and a rapid sol&ndash;gel transition at physiological temperature. MT-ISG1 (MT-LP) and MT-ISG2 (MT-CLPs-0.5) could increase ocular permeability by 2-fold and 4.4-fold compared to MT-ISG (pure MT). MT-ISG2 demonstrated significantly reduced IOP in rabbits without causing any irritation. In conclusion, MT-ISG2 markedly enhanced corneal permeability and reduced IOP. They would be promising carriers for MT for glaucoma management