On the origin of comets

Physico-chemical processes leading to the dynamic formation and physical evolution of comets are reviewed in relationship to the various theories that propose solar origins, protoplanetary origins, planetary origins and interstellar origins. Evidence points to the origins of comets by the growth and agglomeration of small particles from gas and dust at very low temperatures at undetermined regions in space

Expanding horizons of anticoagulant therapy: Dabigatran etexilate a novel oral anticoagulant

Thrombo-embolic disease is a major challenging clinical problem associated with significant mortality and morbidity. Anticoagulation with the existing heparin products and vitamin K antagonist (VKA) anticoagulants are still the mainstay of management. However, due to the risk of bleeding and well-documented drawbacks, the quest for a novel oral anticoagulant has led to the clinical development of dabigatran etexilate. Dabigatran etexilate is a direct thrombin (IIa) inhibitor which has recently been approved in India for prevention of venous thromboembolic events (VTE) in patients who have undergone major orthopaedic (total knee or hip replacement) surgery and for prevention of stroke, systemic embolism and reduction of vascular mortality in adult patients with atrial fibrillation. Thus dabigatran etexilate is a promising alternative to the current heparin products and VKAs in patients who require long-term oral anticoagulation

A Minimum-Mass Extrasolar Nebula

By analogy with the minimum-mass solar nebula, we construct a surface-density profile using the orbits of the 26 precise-Doppler planets found in multiple planet systems: Sigma = 2200 grams per square centimeter (a/1 AU)^- beta, where a is the circumstellar radius, and beta = 2.0 plus or minus 0.5. The minimum-mass solar nebula is consistent with this model, but the uniform-alpha accretion disk model is not. In a nebula with beta > 2, the center of the disk is the likely cradle of planet formation.Comment: 15 pages, including 2 figures. To appear in ApJ, 9/04 new version with prettier page layou

Winds, B-Fields, and Magnetotails of Pulsars

We investigate the emission of rotating magnetized neutron stars due to the acceleration and radiation of particles in the relativistic wind and in the magnetotail of the star. We consider that the charged particles are accelerated by driven collisionless reconnection. Outside of the light cylinder, the star's rotation acts to wind up the magnetic field to form a predominantly azimuthal, slowly decreasing with distance, magnetic field of opposite polarity on either side of the equatorial plane normal to the star's rotation axis. The magnetic field annihilates across the equatorial plane with the magnetic energy going to accelerate the charged particles to relativistic energies. For a typical supersonically moving pulsar, the star's wind extends outward to the standoff distance with the interstellar medium. At larger distances, the power output of pulsar's wind $\dot{E}_w$ of electromagnetic field and relativistic particles is {\it redirected and collimated into the magnetotail} of the star. In the magnetotail it is proposed that equipartition is reached between the magnetic energy and the relativistic particle energy. For such conditions, synchrotron radiation from the magnetotails may be a significant fraction of $\dot{E}_w$ for high velocity pulsars. An equation is derived for the radius of the magnetotail $r_m(z^\prime)$ as a function of distance $z^\prime$ from the star. For large distances $z^\prime$, of the order of the distance travelled by the star, we argue that the magnetotail has a `trumpet' shape owing to the slowing down of the magnetotail flow.Comment: 11 pages, 4 figures, accepted for publication in Ap

Reports of planetary geology program, 1977-1978

A compilation of abstracts of reports which summarizes work conducted by Planetary Geology Principal Investigators and their associates is presented. Full reports of these abstracts were presented to the annual meeting of Planetary Geology Principal Investigators and their associates at the Universtiy of Arizona, Tucson, Arizona, May 31, June 1 and 2, 1978

Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model

The influence of long-term exposure to cadmium (Cd) on essential minerals was investigated using a Caco-2 TC7 cells and a multi-analytical tool: microwave digestion and inductively coupled plasma mass spectrometry. Intracellular levels, effects on cadmium accumulation, distribution, and reference concentration ranges of the following elements were determined: Na, Mg, Ca, Cr, Fe, Mn, Co, Ni, Cu, Zn, Mo, and Cd. Results showed that Caco-2 TC7 cells incubated long-term with cadmium concentrations ranging from 0 to 10 lmol Cd/l for 5 weeks exhibited a significant increase in cadmium accumulation. Furthermore, this accumulation was more marked in cells exposed long-term to cadmium compared with controls, and that this exposure resulted in a significant accumulation of copper and zinc but not of the other elements measured. Interactions of Cd with three elements: zinc, copper, and manganese were particularly studied. Exposed to 30 lmol/l of the element, manganese showed the highest inhibition and copper the lowest on cadmium intracellular accumulation but Zn, Cu, and Mn behave differently in terms of their mutual competition with Cd. Indeed, increasing cadmium in the culture medium resulted in a gradual and significant increase in the accumulation of zinc. There was a significant decrease in manganese from 5 lmol Cd/l exposure, and no variation was observed with copper. Abbreviation: AAS – Atomic absorption spectrometry; CRM– Certified reference material; PBS – Phosphate buffered saline without calcium and magnesium; DMEM – Dubelcco’s modified Eagle’s medium

Milestones in the Observations of Cosmic Magnetic Fields

Magnetic fields are observed everywhere in the universe. In this review, we concentrate on the observational aspects of the magnetic fields of Galactic and extragalactic objects. Readers can follow the milestones in the observations of cosmic magnetic fields obtained from the most important tracers of magnetic fields, namely, the star-light polarization, the Zeeman effect, the rotation measures (RMs, hereafter) of extragalactic radio sources, the pulsar RMs, radio polarization observations, as well as the newly implemented sub-mm and mm polarization capabilities. (Another long paragraph is omitted due to the limited space here)Comment: Invited Review (ChJA&A); 32 pages. Sorry if your significant contributions in this area were not mentioned. Published pdf & ps files (with high quality figures) now availble at http://www.chjaa.org/2002_2_4.ht

The East-West method: an exposure-independent method to search for large scale anisotropies of cosmic rays

The measurement of large scale anisotropies in cosmic ray arrival directions at energies above 10^13 eV is performed through the detection of Extensive Air Showers produced by cosmic ray interactions in the atmosphere. The observed anisotropies are small, so accurate measurements require small statistical uncertainties, i.e. large datasets. These can be obtained by employing ground detector arrays with large extensions (from 10^4 to 10^9 m^2) and long operation time (up to 20 years). The control of such arrays is challenging and spurious variations in the counting rate due to instrumental effects (e.g. data taking interruptions or changes in the acceptance) and atmospheric effects (e.g. air temperature and pressure effects on EAS development) are usually present. These modulations must be corrected very precisely before performing standard anisotropy analyses, i.e. harmonic analysis of the counting rate versus local sidereal time. In this paper we discuss an alternative method to measure large scale anisotropies, the "East-West method", originally proposed by Nagashima in 1989. It is a differential method, as it is based on the analysis of the difference of the counting rates in the East and West directions. Besides explaining the principle, we present here its mathematical derivation, showing that the method is largely independent of experimental effects, that is, it does not require corrections for acceptance and/or for atmospheric effects. We explain the use of the method to derive the amplitude and phase of the anisotropy and we demonstrate its power under different conditions of detector operation

Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study

Background: There is a need to better distinguish viral infections from antibiotic-requiring bacterial infections in children presenting with clinical community-acquired pneumonia (CAP) to assist health care workers in decision making and to improve the rational use of antibiotics.Objective: The overall aim of the Trial of Respiratory infections in children for ENhanced Diagnostics (TREND) study is to improve the differential diagnosis of bacterial and viral etiologies in children aged below 5 years with clinical CAP, by evaluating myxovims resistance protein A (MxA) as a biomarker for viral CAP and by evaluating an existing (multianalyte point-of-care antigen detection test system [mariPOC respi] ArcDia International Oy Ltd.) and a potential future point-of-care test for respiratory pathogens.Methods: Children aged 1 to 59 months with clinical CAP as well as healthy, hospital-based, asymptomatic controls will be included at a pediatric emergency hospital in Stockholm, Sweden. Blood (analyzed for MxA and C-reactive protein) and nasopharyngeal samples (analyzed with real-time polymerase chain reaction as the gold standard and antigen-based mariPOC respi test as well as saved for future analyses of a novel recombinase polymerase amplification-based point-of-care test for respiratory pathogens) will be collected. A newly developed algorithm for the classification of CAP etiology will be used as the reference standard.Results: A pilot study was performed from June to August 2017. The enrollment of study subjects started in November 2017. Results are expected by the end of 2019.Conclusions: The findings from the TREND study can be an important step to improve the management of children with clinical CAP