105 research outputs found

    Technology "Debate" as a tool for communicative competence development

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    The task of a modern university is to produce a highly qualified and competent specialist, ready for independent implementation of professional activities. Communicative competence is one of the fundamental in such preparation. The purpose of the article is to review the experience of implementing the Debate technology as an effective means of developing communicative competence of future vocational training teachers. The article focuses on the specifics of their future activities, its features and conditions, as well as their role in the field of professional education. The teacher of vocational training carries out pedagogical, educational-production and organizational-methodological activities in students training in secondary vocational schools. The basis for the implementation of his professional activity is the construction of effective interaction in the classroom between the teacher and students. For this, future teachers of vocational training must master communicative competence which is one of the main components of their future activities success. The article reveals features of the "Debate" and their capabilities in students’ training. The study allowed us to check the level of communicative competence development in dynamics, as well as to identify the level of students' motivation before using the Debate technology and after. Based on the data obtained, we can talk about the effectiveness of technology implementation. "Debate" provides ample opportunities for students to develop interaction skills, conduct constructive dialogue, select arguments, effective interaction strategies, the ability to balance emotional stress during the discussion, the ability to speak in public and other skills that contribute to the development of communicative competence and provide highly qualified specialist training

    Average time scale for Dome Fuji ice core, East Antarctica

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    Three different approaches to ice-core age dating are employed to develop a depth-age relationship at Dome F: (1) correlation of the ice-core isotope record to the geophysical metronome(Milankovich surface temperature cycle) inferred from the deep borehole temperature profile at Vostok,(2) importing a known chronology from another(Devils Hole) paleoclimatic signal, and(3) direct ice sheet flow modeling. Inverse Monte Carlo sampling is used to constrain the accumulation rate reconstruction and ice flow simulations in order to find the best-fit glaciological time scale matched with the two other chronologies. General uncertainty of the different age estimates varies from 2 to 6kyr on average and reaches 6-14kyr at maximum. Whatever the causes of this discrepancy might be, they are thought to be of different origins, and the age errors are assumed to be independent. Thus, the average time scale for the Dome F ice core down to a depth of 2500m(ice age of 335kyr) is deduced consistently with all three age-depth relationships within the standard deviation limits of Β±3.3kyr, and its accuracy is estimated as 1.4kyr on average. The constrained ice-sheet flow model allows extrapolation of the ice age-depth curve further to the glacier bottom and predicts the ages at depths of 2800, 3000, and 3050m to be 615Β±70, 1560Β±531, and 2985Β±1568kyr, respectively

    Vostok (Antarctica) ice-core time-scale from datings of different origins

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    Three different approaches to ice-core age dating are employed to develop a depth-age relationship at Vostok, Antarctica: (1) correlating the ice-core isotope record to the geophysical metronome (Milankovich surface temperature cycles) inferred from the borehole temperature profile, (2) importing a known chronology from another (Devils Hole, Nevada, USA) paleoclimatic signal, and (3) direct ice-sheet flow modeling. Inverse Monte Carlo sampling is used to constrain the accumulation-rate reconstruction and ice-flow simulations in order to find the best-fit glaciological time-scale matched with the two other chronologies. The general uncertainty of the different age estimates varies from 2 to 6 kyr on average and reaches 6-15 kyr at maximum. Whatever the causes of this discrepancy might be, they are thought to be of different origins, and the age errors are assumed statistically independent. Thus, the average time-scale for the Vostok ice core down to 3350 m depth is deduced consistent with all three dating procedures within the standard deviation limits of ± 3.6kyr, and its accuracy is estimated as 2.2 kyr on average. The constrained ice-sheet flow model allows, at least theoretically, extrapolation of the ice age-depth curve further to the boundary with the accreted lake ice where (at 3530 m depth) the glacier-ice age may reach ∼2000 kyr

    Socio-gaming technology in the development of students’ personality

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    In response to modern needs of the labor market in highly qualified specialists capable of independent and creative activities, higher education institutions are developing professional competence of students using various innovative technologies that contribute to enhancing students' cognitive position. The implementation of modern educational technologies in the system of vocational education is a necessity dictated by the conditions of a competency-based educational paradigm. The peculiarity of educational technology as an effective means of forming professional competence is to ensure the guaranteed achievement of goals. In preparing a student for professional activity, technologies that allow a student to be immersed in conditions as close as possible to professional ones are of particular relevance. The advantage of socio-gaming technologies implementation consists both in revealing a student’s capabilities, his potential, including each of them in the educational process, and in shaping students' ability to master the norms and rules of behavior in society. The purpose of the article is to review the experience of implementing socio-gaming technologies in the training of students of higher educational institutions. Communicative competence is one of the most significant elements of preparing students for both professional activities and life in society. The article presents a study to verify the level of formation of communicative competence. The level was established according to certain criteria related to inclusion in the learning process, building effective interaction with other students. Statistical analysis showed the effectiveness of the technology under consideration. An additional survey of students made it possible to establish that the game contributes to their active involvement in educational process and construction of effective communication with classmates

    ИсслСдованиС олСогСля Π½Π° основС ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚ΠΎΠ² Helianthus annuus L. ΠΈ Rosmarinus officinalis L. Π² качСствС Ρ„Ρ€ΠΈΡ‚ΡŽΡ€Π½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π°

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    The aim of this study was to study the oxidation resistance and functional properties of oleogels based on high oleic oil and wax from Helianthus annuus L. with the addition of a natural complex antioxidant β€” an extract from Rosmarinus officinalis L. and lecithin from Helianthus annuus L. β€” when used as a frying medium for French-fries. High oleic sunflower oil was structured into an oleogel with sunflower wax at a dosage of 5%. Studies were carried out to determine the possibility of replacing the synthetic antioxidant tert-butylhydroquinone at a dosage of 200 mg/kg with a natural antioxidant based on rosemary extract and sunflower lecithin in an oleogel with a defoamer. It was determined that the introduction of sunflower wax increased the induction period of high-oleic sunflower oil by 1.6 times, and the additional introduction of defoamer and antioxidants increased this figure by 1.8–2 times. The rate of accumulation of oxidation products in oil, which is characterized by the level of total polar materials, decreased when wax and antioxidants were added. The degree of thermal oxidation most quickly reached the limit value in oil without additives; in oleogels, it significantly decreased. The introduction of sunflower wax into oil contributed to a noticeable decrease in the absorption of oil by potatoes: fried in oleogel, it absorbed 34–38% less oil than fried in oil without additives. The addition of 0.07% rosemary extract with sunflower lecithin to the oleogel increased the operating time of frying oil by at least 2 times, approximately the same as that of the oleogel with tert-butylhydroquinone. This makes it possible to replace the synthetic antioxidant in deepfrying oleogel with natural rosemary extract with sunflower lecithin. The developed oleogel is a frying oil that has a longer service life and allows you to get fried products with a lower amount of fat.ЦСлью настоящСго исслСдования являлось ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ устойчивости ΠΊ окислСнию ΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… свойств ΠΎΠ»Π΅ΠΎΠ³Π΅Π»Π΅ΠΉ Π½Π° основС высокоолСинового масла ΠΈ воска ΠΈΠ· Helianthus annuus L. с Π²Π²ΠΎΠ΄ΠΎΠΌ Π½Π°Ρ‚ΡƒΡ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ комплСксного антиокислитСля β€” экстракта ΠΈΠ· Rosmarinus officinalis L. ΠΈ Π»Π΅Ρ†ΠΈΡ‚ΠΈΠ½Π° ΠΈΠ· Helianthus annuus L. β€” ΠΏΡ€ΠΈ использовании ΠΈΡ… Π² качСствС ΠΆΠ°Ρ€ΠΎΡ‡Π½ΠΎΠΉ срСды для картофСля-Ρ„Ρ€ΠΈ. ВысокоолСиновоС подсолнСчноС масло Π±Ρ‹Π»ΠΎ структурировано Π² олСогСль подсолнСчным воском Π² Π΄ΠΎΠ·ΠΈΡ€ΠΎΠ²ΠΊΠ΅ 5%. ΠŸΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ исслСдования ΠΏΠΎ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΡŽ возмоТности Π·Π°ΠΌΠ΅Π½Ρ‹ синтСтичСского антиокислитСля Ρ‚Ρ€Π΅Ρ‚-Π±ΡƒΡ‚ΠΈΠ»Π³ΠΈΠ΄Ρ€ΠΎΡ…ΠΈΠ½ΠΎΠ½Π° Π² Π΄ΠΎΠ·ΠΈΡ€ΠΎΠ²ΠΊΠ΅ 200 ΠΌΠ³/ΠΊΠ³ Π½Π° Π½Π°Ρ‚ΡƒΡ€Π°Π»ΡŒΠ½Ρ‹ΠΉ Π°Π½Ρ‚ΠΈΠΎΠΊΠΈΡΠ»ΠΈΡ‚Π΅Π»ΡŒ Π½Π° основС экстракта Ρ€ΠΎΠ·ΠΌΠ°Ρ€ΠΈΠ½Π° ΠΈ подсолнСчного Π»Π΅Ρ†ΠΈΡ‚ΠΈΠ½Π° Π² ΠΎΠ»Π΅ΠΎΠ³Π΅Π»Π΅ с пСногаситСлСм. Π‘Ρ‹Π»ΠΎ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΎ, Ρ‡Ρ‚ΠΎ внСсСниС подсолнСчного воска ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ»ΠΎ ΠΈΠ½Π΄ΡƒΠΊΡ†ΠΈΠΎΠ½Π½Ρ‹ΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ высокоолСинового подсолнСчного масла Π² 1.6 Ρ€Π°Π·Π°, Π° Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ Π²Π²ΠΎΠ΄ пСногаситСля ΠΈ антиокислитСлСй ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ» Π΄Π°Π½Π½Ρ‹ΠΉ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ ΡƒΠΆΠ΅ Π² 1.8–2 Ρ€Π°Π·Π°. Π‘ΠΊΠΎΡ€ΠΎΡΡ‚ΡŒ накоплСния ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚ΠΎΠ² окислСния Π² маслС, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΡƒΡŽΡ‰Π°ΡΡΡ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ ΠΎΠ±Ρ‰ΠΈΡ… полярных вСщСств, ΠΏΡ€ΠΈ внСсСнии воска ΠΈ антиокислитСлСй сниТалась. Π‘Ρ‚Π΅ΠΏΠ΅Π½ΡŒ тСрмичСского окислСния быстрСС всСх достигла ΠΏΡ€Π΅Π΄Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ значСния Π² маслС Π±Π΅Π· Π΄ΠΎΠ±Π°Π²ΠΎΠΊ, Π² олСогСлях ΠΎΠ½Π° Π·Π°ΠΌΠ΅Ρ‚Π½ΠΎ сниТалась. Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ Π² масло подсолнСчного воска способствовало Π·Π°ΠΌΠ΅Ρ‚Π½ΠΎΠΌΡƒ сниТСнию впитываСмости масла ΠΊΠ°Ρ€Ρ‚ΠΎΡ„Π΅Π»Π΅ΠΌ: ΠΎΠ±ΠΆΠ°Ρ€Π΅Π½Π½Ρ‹ΠΉ Π² ΠΎΠ»Π΅ΠΎΠ³Π΅Π»Π΅, ΠΎΠ½ Π²ΠΏΠΈΡ‚Ρ‹Π²Π°Π» Π½Π° 34–38% мСньшС масла, Ρ‡Π΅ΠΌ ΠΎΠ±ΠΆΠ°Ρ€Π΅Π½Π½Ρ‹ΠΉ Π² маслС Π±Π΅Π· Π΄ΠΎΠ±Π°Π²ΠΎΠΊ. ВнСсСниС Π² олСогСль 0.07% экстракта Ρ€ΠΎΠ·ΠΌΠ°Ρ€ΠΈΠ½Π° с подсолнСчным Π»Π΅Ρ†ΠΈΡ‚ΠΈΠ½ΠΎΠΌ ΡƒΠ²Π΅Π»ΠΈΡ‡ΠΈΠ²Π°Π»ΠΎ врСмя эксплуатации Ρ„Ρ€ΠΈΡ‚ΡŽΡ€Π½ΠΎΠ³ΠΎ ΠΆΠΈΡ€Π° Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Ρ‡Π΅ΠΌ Π² 2 Ρ€Π°Π·Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π½ΠΎ Ρ‚Π°ΠΊΠΆΠ΅, ΠΊΠ°ΠΊ ΠΈ Ρƒ олСогСля с Ρ‚Ρ€Π΅Ρ‚-Π±ΡƒΡ‚ΠΈΠ»Π³ΠΈΠ΄Ρ€ΠΎΡ…ΠΈΠ½ΠΎΠ½ΠΎΠΌ. Π­Ρ‚ΠΎ Π΄Π°Π΅Ρ‚ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ произвСсти Π·Π°ΠΌΠ΅Π½Ρƒ синтСтичСского антиокислитСля Π² ΠΎΠ»Π΅ΠΎΠ³Π΅Π»Π΅ для Ρ„Ρ€ΠΈΡ‚ΡŽΡ€Π° Π½Π° Π½Π°Ρ‚ΡƒΡ€Π°Π»ΡŒΠ½Ρ‹ΠΉ экстракт Ρ€ΠΎΠ·ΠΌΠ°Ρ€ΠΈΠ½Π° с подсолнСчным Π»Π΅Ρ†ΠΈΡ‚ΠΈΠ½ΠΎΠΌ. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π½Ρ‹ΠΉ олСогСль являСтся Ρ„Ρ€ΠΈΡ‚ΡŽΡ€Π½Ρ‹ΠΌ ΠΆΠΈΡ€ΠΎΠΌ, ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΠΌ Π±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ срок эксплуатации ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡŽΡ‰ΠΈΠΌ ΠΏΠΎΠ»ΡƒΡ‡Π°Ρ‚ΡŒ ΠΎΠ±ΠΆΠ°Ρ€Π΅Π½Π½Ρ‹Π΅ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Ρ‹ с Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΈΠΌ количСством ΠΆΠΈΡ€Π°

    Wastewater treatment electroplating plants from ions of copper by coagulation

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    In the article the urgent problems of purification of wastewater. The physicochemical method of wastewater treatment of electroplating plants was studied. The main types of coagulants are considered.Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ рассмотрСны Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ очистки сточных Π²ΠΎΠ΄. Π˜Π·ΡƒΡ‡Π΅Π½ Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСский способ очистки сточных Π²ΠΎΠ΄ Π³Π°Π»ΡŒΠ²Π°Π½ΠΈΡ‡Π΅ΡΠΊΠΈΡ… производств. РассмотрСны основныС Ρ‚ΠΈΠΏΡ‹ коагулянтов

    Special Economic Zones in Russia: Practice of Application of Tax Incentives and Assessment of Efficiency

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    The article considers the features of the application of fiscal instruments in the special economic zones of Russia in the context of the effectiveness of tax incentives and preferential tax treatment. The purpose of the article is to formulate proposals on improving the methodology of assessment of the efficiency of the special economic zones of the Russia. The basic methods of research were analyses, synthesis and comparative analysis. The study was based on the results of the operation of nine Russian special economic zones of various types launched at least seven years ago. As special economic zones are an instrument for future economic development and growth, assessing the efficiency of such zones is difficult. In the article, the authors analyzed the methods for assessing the effectiveness of special economic zones applied at different times, identified their main similarities and differences. The article analyses imperfections of the methodology for estimating special economic zones based on projected values of indicators: the number of residents, the number of jobs created in the zone, the amount of attracted investments, etc. This approach does not always allow for an effective assessment of a special economic zone because the target values of the indicators may initially be incorrect. The concept of the effectiveness of a special economic zone is proposed to be considered from the point of view the budgetary costs and benefits, as well as in the context of the socio-economic development of the region that hosts the zone. Analysis of the development of special economic zones can become more objective when the existing methodology for assessing the effectiveness is complemented with indicators that reflect the impact of special economic zones on the level of social and economic development of the region.Π‘Ρ‚Π°Ρ‚ΡŒΡ посвящСна вопросам примСнСния Ρ„ΠΈΡΠΊΠ°Π»ΡŒΠ½Ρ‹Ρ… инструмСнтов Π½Π° тСрриториях особых экономичСских Π·ΠΎΠ½ России с Ρ‚ΠΎΡ‡ΠΊΠΈ зрСния эффСктивности прСдоставляСмых Π»ΡŒΠ³ΠΎΡ‚ ΠΈ ΠΏΡ€Π΅Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠΉ. ЦСль ΡΡ‚Π°Ρ‚ΡŒΠΈ – Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½ΠΈΠΉ ΠΎ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΠΈ примСняСмой Π² настоящСС врСмя ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΎΡ†Π΅Π½ΠΊΠΈ эффСктивности функционирования особых экономичСских Π·ΠΎΠ½ России. Π‘Π°Π·ΠΎΠ²Ρ‹ΠΌΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ исслСдования являлись Π°Π½Π°Π»ΠΈΠ·, синтСз ΠΈ ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ·. ИсслСдованиС ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°Π»ΠΎΡΡŒ Π½Π° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°Ρ… Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ дСвяти российских особых экономичСских Π·ΠΎΠ½ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Ρ‚ΠΈΠΏΠΎΠ² со сроком функционирования Π±ΠΎΠ»Π΅Π΅ 7 Π»Π΅Ρ‚. ΠŸΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΈ с особым экономичСским статусом ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡŽΡ‚ собой инструмСнт экономичСского развития, ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΉ Π½Π° пСрспСктиву, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΎΡ†Π΅Π½ΠΊΠΈ Π΅Π³ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈΠ²Π½ΠΎΡΡ‚ΠΈ ΠΈ эффСктивности Π²Ρ‹Π·Ρ‹Π²Π°Π΅Ρ‚ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½Ρ‹Π΅ трудности. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Π°Π²Ρ‚ΠΎΡ€Π°ΠΌΠΈ ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΎΡ†Π΅Π½ΠΊΠΈ эффСктивности развития особых экономичСских Π·ΠΎΠ½, примСняСмыС Π² Ρ€Π°Π·Π½Ρ‹Π΅ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Ρ‹ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ, ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ ΠΈΡ… основныС сходства ΠΈ различия. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½ΠΎ обоснованиС Π½Π΅ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΎΡ†Π΅Π½ΠΊΠΈ особых экономичСских Π·ΠΎΠ½, основанной прСимущСствСнно Π½Π° Π°Π½Π°Π»ΠΈΠ·Π΅ выполнСния ΠΏΠ»Π°Π½ΠΎΠ²Ρ‹Ρ… Π·Π½Π°Ρ‡Π΅Π½ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ: количСства Ρ€Π΅Π·ΠΈΠ΄Π΅Π½Ρ‚ΠΎΠ², числа созданных ΠΈΠΌΠΈ Ρ€Π°Π±ΠΎΡ‡ΠΈΡ… мСст, объСмов ΠΏΡ€ΠΈΠ²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Ρ… инвСстиций ΠΈ Ρ‚. ΠΏ. Π”Π°Π½Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ Π½Π΅ всСгда позволяСт эффСктивно ΠΎΡ†Π΅Π½ΠΈΡ‚ΡŒ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡ‡Π΅ΡΠΊΡƒΡŽ Π·ΠΎΠ½Ρƒ, ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ ΠΏΠ»Π°Π½ΠΎΠ²Ρ‹Π΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΠ·Π½Π°Ρ‡Π°Π»ΡŒΠ½ΠΎ Π½Π΅ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚Π½Ρ‹. ΠŸΠΎΠ½ΡΡ‚ΠΈΠ΅ эффСктивности особой экономичСской Π·ΠΎΠ½Ρ‹ прСдлагаСтся Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒ с Ρ‚ΠΎΡ‡ΠΊΠΈ зрСния Π½Π΅ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Π±ΡŽΠ΄ΠΆΠ΅Ρ‚Π½Ρ‹Ρ… Π·Π°Ρ‚Ρ€Π°Ρ‚ ΠΈ Π²Ρ‹Π³ΠΎΠ΄, Π½ΠΎ ΠΈ с ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΈ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСского развития Ρ€Π΅Π³ΠΈΠΎΠ½Π°, Π½Π° Ρ‚Π΅Ρ€Ρ€ΠΈΡ‚ΠΎΡ€ΠΈΠΈ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ³ΠΎ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΡƒΠ΅Ρ‚ особая экономичСская Π·ΠΎΠ½Π°. Анализ развития особых экономичСских Π·ΠΎΠ½ ΠΌΠΎΠΆΠ΅Ρ‚ ΡΡ‚Π°Ρ‚ΡŒ Π΄Π΅ΠΉΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΠΎΠ±ΡŠΠ΅ΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌ ΠΈ Ρ€Π°Ρ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌ ΠΏΡ€ΠΈ Π΄ΠΎΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰Π΅ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΎΡ†Π΅Π½ΠΊΠΈ эффСктивности показатСлями, ΠΎΡ‚Ρ€Π°ΠΆΠ°ΡŽΡ‰ΠΈΠΌΠΈ влияниС особых экономичСских Π·ΠΎΠ½ Π½Π° ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСского развития Ρ€Π΅Π³ΠΈΠΎΠ½Π°

    НСпосрСдствСнныС ΠΈ ΠΎΡ‚Π΄Π°Π»Π΅Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΉ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ: ΠΎΠΏΡ‹Ρ‚ ΠΎΠ΄Π½ΠΎΠ³ΠΎ учрСТдСния

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    The purpose of the study was to evaluate the outcomes of a series of liver resections performed in a single regional specialized cancer center. Material and Methods. Eighty-nine patients underwent liver and/ or extrahepatic bile duct resections in the Penza Regional Oncology Hospital over the 8-year study period. Malignancies were observed in 81 patients. Extended liver resections (4 segments or more) were performed in 58 (65.2 %) cases. Results. Postsurgical morbidity and mortality rates were 31.5 % (28 of 89) and 6.7 % (6 of 89), respectively. Six of 10 patients with primary liver carcinomas were alive without evidence of disease progression at a follow-up time ranged from 1.0 to 76.7 months. Adjuvant chemotherapy (ACT) was the only predictor (HR=0.40; 95 % CI 0.16-0.98) of overall survival in patients with metastatic colorectal cancer (mCRC). The median survival time after liver resections for mCRC with or without ACT was 54.5 (95 % CI: 14.5-94.5) vs 21.8 months (95 % CI: 14.2-29.4), respectively. In mCRC patients with ACT, the 5-year overall survival rate was 44.8 Β± 12.9 %. Conclusion. Primary hepatobiliary carcinomas and colorectal cancer liver metastases are the most common reasons for liver resections. A series of liver resections in a low-volume hospital is feasible with the achievement of good outcomes.ЦСль исслСдования - ΠΎΡ†Π΅Π½ΠΊΠ° Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² сСрийного выполнСния Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΉ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ Π² условиях Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ спСциализированного онкологичСского учрСТдСния. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ ПСнзСнском областном онкологичСском диспансСрС Π·Π° 8 Π»Π΅Ρ‚ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΈ/ΠΈΠ»ΠΈ Π²Π½Π΅ΠΏΠ΅Ρ‡Π΅Π½ΠΎΡ‡Π½Ρ‹Ρ… ΠΆΠ΅Π»Ρ‡Π½Ρ‹Ρ… ΠΏΡ€ΠΎΡ‚ΠΎΠΊΠΎΠ² Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Ρ‹ 89 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°ΠΌ. ЗлокачСствСнныС ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ Π±Ρ‹Π»ΠΈ Ρƒ 81 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°. ΠžΠ±ΡˆΠΈΡ€Π½Ρ‹Π΅ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ (4 ΠΈ Π±ΠΎΠ»Π΅Π΅ сСгмСнтов) ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ Π² 58 (65,2 %) Π½Π°Π±Π»ΡŽΠ΄Π΅Π½ΠΈΡΡ…. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΠΎΡΠ»Π΅ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½Ρ‹Π΅ ослоТнСния зарСгистрированы Ρƒ 28 (31,5 %) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ². Π›Π΅Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΉ исход наступил Ρƒ 6 (6,7 %) ΠΈΠ· 89 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½Ρ‹Ρ… ΠΊΠ°Ρ€Ρ†ΠΈΠ½ΠΎΠΌ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΈΠ· 10 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΡˆΠ΅ΡΡ‚Π΅Ρ€ΠΎ ΠΆΠΈΠ²Ρ‹ Π² сроки ΠΎΡ‚ 1 Π΄ΠΎ 76,7 мСс. ΠΠ΄ΡŠΡŽΠ²Π°Π½Ρ‚Π½Π°Ρ химиотСрапия (АΠ₯Π’) Π±Ρ‹Π»Π° СдинствСнным ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€ΠΎΠΌ (HR=0,4; 95 % Π”Π˜ 0,16-0,98) ΠΎΠ±Ρ‰Π΅ΠΉ выТиваСмости Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с мСтастазами ΠΊΠΎΠ»ΠΎΡ€Π΅ΠΊΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ° (мКРР). ΠœΠ΅Π΄ΠΈΠ°Π½Ρ‹ выТиваСмости с/Π±Π΅Π· АΠ₯Π’ послС Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΈ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρƒ мКРР составили 54,5 (95 % Π”Π˜ 14,5-94,5) vs 21,8 мСс (95 % Π”Π˜ 14,2-29,4) соотвСтствСнно. 5-лСтняя Π²Ρ‹ΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡ‚ΡŒ Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с АΠ₯Π’ - 44,8 Β± 12,9 %. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π’ структурС Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΉ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ ΠΏΡ€Π΅Π²Π°Π»ΠΈΡ€ΡƒΡŽΡ‚ ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΈ ΠΏΠΎ ΠΏΠΎΠ²ΠΎΠ΄Ρƒ ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½Ρ‹Ρ… Π³Π΅ΠΏΠ°Ρ‚ΠΎ-Π±ΠΈΠ»ΠΈΠ°Ρ€Π½Ρ‹Ρ… ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈ мСтастазов ΠΊΠΎΠ»ΠΎΡ€Π΅ΠΊΡ‚Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ€Π°ΠΊΠ°. Π‘Π΅Ρ€ΠΈΠΉΠ½ΠΎΠ΅ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ Ρ€Π΅Π·Π΅ΠΊΡ†ΠΈΠΉ ΠΏΠ΅Ρ‡Π΅Π½ΠΈ Π² условиях мСдицинской ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ 3-Π³ΠΎ уровня Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ с достиТСниСм устойчивого ΡƒΠ΄ΠΎΠ²Π»Π΅Ρ‚Π²ΠΎΡ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°

    ЀСнотипичСская ΠΏΠ»Π°ΡΡ‚ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ мСтастатичСской ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹

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    Introduction. Metastatic melanoma is characterized by clinical and morphological heterogeneity and plasticity. Rare cases of metastatic melanoma are known, that have no visual expression of melanocytic markers. Contradictory histology of such melanomas requires a differential diagnosis from morphologically similar non- melanocytic tumors, sarcoma or lymphoma. objective is to describe the extraordinary cases of metastatic melanomas with low expression of differentiation markers. material and methods. 15 melanoma cases with unusual clinical and morphological characteristics were included in the study. These tumors were examined by pathologist and cytologist, by immunohistochemical and FISH analyses, mutations in BRAF, NRAS and KIT genes were detected by PCR. results. Some primary tumors were amelanotic, therefore, they were difficult for differential tumor diagnosis. Most frequently, primary tumors were located on the back, shin or head. In 4 patients the primary focuses were not detected. Metastatic lesions were as large nodular tumors in soft tissues of the back or lower limb. Most tumors belong to mixed or spindle-cell histological types. Spindle-shaped cells were also revealed by cytological analysis. BRAF gene mutations were identified by genetic analysis in 27 % of tumors, NRAS and KIT gene mutations were not detected. In 4 cases FISH analysis was performed to detect EWSR1 gene rearrangements, but it did not confirm the diagnosis of sarcoma. conclusion. The results indicate the presence of a heterogeneous group of melanoma cases, which have a number of morphological and molecular features that bring them closer to sarcomas.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. ΠœΠ΅Ρ‚Π°ΡΡ‚Π°Ρ‚ΠΈΡ‡Π΅ΡΠΊΠ°Ρ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΠ° отличаСтся ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-морфологичСской Π³Π΅Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒΡŽ ΠΈ ΠΏΠ»Π°ΡΡ‚ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒΡŽ. Π’ΡΡ‚Ρ€Π΅Ρ‡Π°ΡŽΡ‚ΡΡ Ρ€Π΅Π΄ΠΊΠΈΠ΅ случаи мСтастатичСской ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ практичСски Π½Π΅ ΡΠΊΡΠΏΡ€Π΅ΡΡΠΈΡ€ΡƒΡŽΡ‚ ΠΌΠ΅Π»Π°Π½ΠΎΡ†ΠΈΡ‚Π°Ρ€Π½Ρ‹Ρ… ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ². Π“ΠΈcтологичСски Ρ‚Π°ΠΊΠΈΠ΅ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹ Ρ‚Ρ€Π΅Π±ΡƒΡŽΡ‚ Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΈΜ† диагностики ΠΎΡ‚ морфологичСски сходных Π½Π΅ΠΌΠ΅Π»Π°Π½ΠΎΡ†ΠΈΡ‚Π°Ρ€Π½Ρ‹Ρ… ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΈΜ†, саркомы ΠΈΠ»ΠΈ Π»ΠΈΠΌΡ„ΠΎΠΌΡ‹. ЦСль исслСдования – исслСдованиС Π½Π΅ΠΎΡ€Π΄ΠΈΠ½Π°Ρ€Π½Ρ‹Ρ… случаСв мСтастатичСской ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹ с Π½ΠΈΠ·ΠΊΠΎΠΈΜ† экспрСссиСй Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΡ€ΠΎΠ²ΠΎΡ‡Π½Ρ‹Ρ… ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ². ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠžΠΏΠΈΡΠ°Π½Ρ‹ 15 случаСв ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹ с Π½Π΅ΠΎΠ±Ρ‹Ρ‡Π½Ρ‹ΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-морфологичСскими характСристиками. ΠžΠΏΡƒΡ…ΠΎΠ»ΠΈ ΠΏΠΎΠ΄Π²Π΅Ρ€Π³Π»ΠΈΡΡŒ морфологичСскому, цитологичСскому исслСдованию, иммуногистохимичСскому ΠΈ FISH-Π°Π½Π°Π»ΠΈΠ·Ρƒ, Π±Ρ‹Π»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ Π² Π³Π΅Π½Π°Ρ… BRAF, NRAS ΠΈ KIT. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠŸΠ΅Ρ€Π²ΠΈΡ‡Π½Ρ‹Π΅ ΠΌΠ΅Π»Π°Π½ΠΎΠΌΡ‹ часто Π½Π΅ содСрТали ΠΏΠΈΠ³ΠΌΠ΅Π½Ρ‚Π°, Ρ‡Ρ‚ΠΎ затрудняло Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΡƒΡŽ диагностику ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ. ΠžΠΏΡƒΡ…ΠΎΠ»ΠΈ Ρ€Π°ΡΠΏΠΎΠ»Π°Π³Π°Π»ΠΈΡΡŒ Ρ‡Π°Ρ‰Π΅ всСго Π½Π° спинС, Π³ΠΎΠ»Π΅Π½ΠΈ ΠΈΠ»ΠΈ Π³ΠΎΠ»ΠΎΠ²Π΅, Ρƒ 4 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½Ρ‹Π΅ ΠΎΡ‡Π°Π³ΠΈ Π½Π΅ выявлСны. ΠœΠ΅Ρ‚Π°ΡΡ‚Π°Ρ‚ΠΈΡ‡Π΅ΡΠΊΠΈΠ΅ пораТСния прСдставляли собой ΠΊΡ€ΡƒΠΏΠ½Ρ‹Π΅ ΡƒΠ·Π»ΠΎΠ²Ρ‹Π΅ новообразования Π² мягких тканях Π² области спины Π»ΠΈΠ±ΠΎ Π½ΠΈΠΆΠ½Π΅ΠΈΜ† конСчности. Π‘ΠΎΠ»ΡŒΡˆΠΈΠ½ΡΡ‚Π²ΠΎ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΈΜ† ΠΎΡ‚Π½ΠΎΡΠΈΠ»ΠΈΡΡŒ ΠΊ ΡΠΌΠ΅ΡˆΠ°Π½Π½ΠΎΠΌΡƒ ΠΈΠ»ΠΈ Π²Π΅Ρ€Π΅Ρ‚Π΅Π½ΠΎΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠΌΡƒ гистологичСским Ρ‚ΠΈΠΏΠ°ΠΌ. Π’Π΅Ρ€Π΅Ρ‚Π΅Π½ΠΎΠΎΠ±Ρ€Π°Π·Π½Ρ‹Π΅ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ ΠΎΡ‚ΠΌΠ΅Ρ‡Π΅Π½Ρ‹ ΠΈ ΠΏΡ€ΠΈ цитологичСских исслСдованиях. ΠŸΡ€ΠΈ гСнСтичСском Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ Π² Π³Π΅Π½Π΅ BRAF выявлСны Π² 27 % ΠΌΠ΅Π»Π°Π½ΠΎΠΌ, ΠΌΡƒΡ‚Π°Ρ†ΠΈΠΈ Π² Π³Π΅Π½Π°Ρ… NRAS ΠΈ KIT Π½Π΅ ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠ΅Π½Ρ‹. Π’ 4 случаях с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ FISH ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π½Π° Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ Ρ€Π΅Π°Ρ€Π°Π½ΠΆΠΈΡ€ΠΎΠ²ΠΊΠΈ Π³Π΅Π½Π° EWSR1, ΠΏΡ€ΠΈ этом Π΄ΠΈΠ°Π³Π½ΠΎΠ· саркомы Π½Π΅ подтвСрдился. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΡƒΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ Π½Π° Π³ΠΈΡΡ‚ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡƒΠ»ΡΡ€Π½ΡƒΡŽ Π½Π΅ΠΎΠ΄Π½ΠΎΡ€ΠΎΠ΄Π½ΠΎΡΡ‚ΡŒ ΠΈ Ρ„Π΅Π½ΠΎΡ‚ΠΈΠΏΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΏΠ»Π°ΡΡ‚ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ исслСдованных ΠΌΠ΅Π»Π°Π½ΠΎΠΌ. Ряд выявлСнных молСкулярно-гСнСтичСских особСнностСй сблиТаСт эти ΠΎΠΏΡƒΡ…ΠΎΠ»ΠΈ с саркомами
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