126 research outputs found
Shear-Flow Driven Current Filamentation: Two-Dimensional Magnetohydrodynamic Simulations
The process of current filamentation in permanently externally driven,
initially globally ideal plasmas is investigated by means of two-dimensional
Magnetohydrodynamic (MHD)-simulations. This situation is typical for
astrophysical systems like jets, the interstellar and intergalactic medium
where the dynamics is dominated by external forces. Two different cases are
studied. In one case, the system is ideal permanently and dissipative processes
are excluded. In the second case, a system with a current density dependent
resistivity is considered. This resistivity is switched on self-consistently in
current filaments and allows for local dissipation due to magnetic
reconnection. Thus one finds tearing of current filaments and, besides, merging
of filaments due to coalescence instabilities. Energy input and dissipation
finally balance each other and the system reaches a state of constant magnetic
energy in time.Comment: 32 Pages, 13 Figures. accepted, to appear in Physics of Plasmas
(049012
The critical velocity effect as a cause for the H\alpha emission from the Magellanic stream
Observations show significant H\alpha-emissions in the Galactic halo near the
edges of cold gas clouds of the Magellanic Stream. The source for the
ionization of the cold gas is still a widely open question. In our paper we
discuss the critical velocity effect as a possible explanation for the observed
H\alpha-emission. The critical velocity effect can yield a fast ionization of
cold gas if this neutral gas passes through a magnetized plasma under suitable
conditions. We show that for parameters that are typical for the Magellanic
Stream the critical velocity effect has to be considered as a possible
ionization source of high relevance.Comment: 9 pages, 2 figures. accepted, to appear in The Astrophysical Journa
Caveolin 1 protein expression in renal cell carcinoma predicts survival
<p>Abstract</p> <p>Background</p> <p>Caveolae play a significant role in disease phenotypes such as cancer, diabetes, bladder dysfunction, and muscular dystrophy. The aim of this study was to elucidate the caveolin-1 <it>(</it>CAV1<it>) </it>protein expression in renal cell cancer (RCC) and to determine its potential prognostic relevance.</p> <p>Methods</p> <p>289 clear cell RCC tissue specimens were collected from patients undergoing surgery for renal tumors. Both cytoplasmic and membranous CAV1 expression were determined by immunohistochemistry and correlated with clinical variables. Survival analysis was carried out for 169 evaluable patients with a median follow up of 80.5 months (interquartile range (IQR), 24.5 - 131.7 months).</p> <p>Results</p> <p>A high CAV1 expression in the tumor cell cytoplasm was significantly associated with male sex (p = 0.04), a positive nodal status (p = 0.04), and poor tumor differentiation (p = 0.04). In contrast, a higher than average (i.e. > median) CAV1 expression in tumor cell membranes was only linked to male sex (p = 0.03). Kaplan-Meier analysis disclosed significant differences in 5-year overall (51.4 vs. 75.2%, p = 0.001) and tumor specific survival (55.3 vs. 80.1%, p = 0.001) for patients with higher and lower than average cytoplasmic CAV1 expression levels, respectively. Applying multivariable Cox regression analysis a high CAV1 protein expression level in the tumor cell cytoplasm could be identified as an independent poor prognostic marker of both overall (p = 0.02) and tumor specific survival (p = 0.03) in clear cell RCC patients.</p> <p>Conclusion</p> <p>Over expression of caveolin-1 in the tumour cell cytoplasm predicts a poor prognosis of patients with clear cell RCC. CAV1 is likely to be a useful prognostic marker and may play an important role in tumour progression. Therefore, our data encourage further investigations to enlighten the role of CAV1 and its function as diagnostic and prognostic marker in serum and/or urine of RCC patients.</p
Clinical consequences of consecutive self-expanding transcatheter heart valve iterations
OBJECTIVE: To compare early clinical outcomes after transcatheter aortic valve implantation (TAVI) with three consecutive generations of self-expanding valves (SEVs). METHODS: Clinical endpoints of consecutive patients who underwent TAVI with CoreValve, Evolut R or Evolut PRO were included in a prospective database. RESULTS: TAVI was performed with CoreValve (n = 116), Evolut R (n = 160) or Evolut PRO (n = 92). Evolut R and Evolut PRO showed a tendency towards lower permanent pacemaker implantation (PPI) rates compared to CoreValve (CoreValve 27% vs Evolut R 16% vs Evolut PRO 18%, p = 0.091). By multivariable regression analysis CoreValve had a significantly higher risk for PPI (odds ratio (OR) 2.79, 95% confidence interval (CI) 1.31–5.94, p = 0.008) compared to Evolut R, while Evolut R and PRO were similar. Severe paravalvular leakage (PVL) occurred only with CoreValve, but no significant difference was observed in moderate PVL (10% vs 8% vs 6%, p = 0.49). CoreValve had a tendency towards a higher risk for more-than-mild PVL as compared with the Evolut platform (R + PRO) (OR 2.46, 95% CI 0.98–6.16, p = 0.055). No significant differences in all-cause mortality (7% vs 4% vs 1%, p = 0.10), stroke (6% vs 3% vs 2%, p = 0.21) or major vascular complications (10% vs 12% vs 4%, p = 0.14) were observed. CONCLUSIONS: TAVI with self-expanding valves was safe, and device iterations may result in a lower need for PPI. More-than-mild PVL seemed to occur less often with repositionable technology. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12471-021-01568-5) contains supplementary material, which is available to authorized users
The Kelvin-Helmholtz instability in weakly ionised plasmas: Ambipolar dominated and Hall dominated flows
The Kelvin-Helmholtz instability is well known to be capable of converting
well-ordered flows into more disordered, even turbulent, flows. As such it
could represent a path by which the energy in, for example, bowshocks from
stellar jets could be converted into turbulent energy thereby driving molecular
cloud turbulence. We present the results of a suite of fully multifluid
magnetohydrodynamic simulations of this instability using the HYDRA code. We
investigate the behaviour of the instability in a Hall dominated and an
ambipolar diffusion dominated plasma as might be expected in certain regions of
accretion disks and molecular clouds respectively.
We find that, while the linear growth rates of the instability are unaffected
by multifluid effects, the non-linear behaviour is remarkably different with
ambipolar diffusion removing large quantities of magnetic energy while the Hall
effect, if strong enough, introduces a dynamo effect which leads to continuing
strong growth of the magnetic field well into the non-linear regime and a lack
of true saturation of the instability.Comment: 12 pages, 20 figures. Accepted for publication in MNRA
A new variational approach to the stability of gravitational systems
We consider the three dimensional gravitational Vlasov Poisson system which
describes the mechanical state of a stellar system subject to its own gravity.
A well-known conjecture in astrophysics is that the steady state solutions
which are nonincreasing functions of their microscopic energy are nonlinearly
stable by the flow. This was proved at the linear level by several authors
based on the pioneering work by Antonov in 1961. Since then, standard
variational techniques based on concentration compactness methods as introduced
by P.-L. Lions in 1983 have led to the nonlinear stability of subclasses of
stationary solutions of ground state type.
In this paper, inspired by pioneering works from the physics litterature
(Lynden-Bell 94, Wiechen-Ziegler-Schindler MNRAS 88, Aly MNRAS 89), we use the
monotonicity of the Hamiltonian under generalized symmetric rearrangement
transformations to prove that non increasing steady solutions are local
minimizer of the Hamiltonian under equimeasurable constraints, and extract
compactness from suitable minimizing sequences. This implies the nonlinear
stability of nonincreasing anisotropic steady states under radially symmetric
perturbations
Milestones in the Observations of Cosmic Magnetic Fields
Magnetic fields are observed everywhere in the universe. In this review, we
concentrate on the observational aspects of the magnetic fields of Galactic and
extragalactic objects. Readers can follow the milestones in the observations of
cosmic magnetic fields obtained from the most important tracers of magnetic
fields, namely, the star-light polarization, the Zeeman effect, the rotation
measures (RMs, hereafter) of extragalactic radio sources, the pulsar RMs, radio
polarization observations, as well as the newly implemented sub-mm and mm
polarization capabilities.
(Another long paragraph is omitted due to the limited space here)Comment: Invited Review (ChJA&A); 32 pages. Sorry if your significant
contributions in this area were not mentioned. Published pdf & ps files (with
high quality figures) now availble at http://www.chjaa.org/2002_2_4.ht
The Kelvin-Helmholtz instability in weakly ionised plasmas II: multifluid effects in molecular clouds
We present a study of the Kelvin-Helmholtz instability in a weakly ionised,
multifluid MHD plasma with parameters matching those of a typical molecular
cloud. The instability is capable of transforming well-ordered flows into
disordered flows. As a result, it may be able to convert the energy found in,
for example, bowshocks from stellar jets into the turbulent energy found in
molecular clouds. As these clouds are weakly ionised, the ideal
magnetohydrodynamic approximation does not apply at scales of around a tenth of
a parsec or less. This paper extends the work of Jones & Downes (2011) on the
evolution of the Kelvin-Helmholtz instability in the presence of multifluid
magnetohydrodynamic effects. These effects of ambipolar diffusion and the Hall
effect are here studied together under physical parameters applicable to
molecular clouds. We restrict our attention to the case of a single shear layer
with a transonic, but super-Alfvenic, velocity jump and the computational
domain is chosen to match the wavelength of the linearly fastest growing mode
of the instability.
We find that while the introduction of multifluid effects does not affect the
linear growth rates of the instability, the non-linear behaviour undergoes
considerable change. The magnetic field is decoupled from the bulk flow as a
result of the ambipolar diffusion, which leads to a significant difference in
the evolution of the field. The Hall effect would be expected to lead to a
noticeable re-orientation of the magnetic field lines perpendicular to the
plane. However, the results reveal that the combination with ambipolar
diffusion leads to a surprisingly effective suppression of this effect.Comment: 13 pages, 13 figures, accepted for publication in MNRA
Suppression of the c-erbB-2 gene product decreases transformation abilities but not the proliferation and secretion of proteases of SK-OV-3 ovarian cancer cells
The overexpression of the c-erbB-2 oncogene product has been reported in approximately 20–30% of human ovarian cancers and has been correlated with a poor prognosis in ovarian cancer patients. To investigate the function of p185c-erbB-2 in human ovarian cancer cells, a c-erbB-2-specific single-chain antibody (scFv-5R) was expressed in the c-erbB-2-overexpressing SK-OV-3 cell line using a retroviral expression vector. Eight individual clones expressing the single-chain antibody were isolated. These clones have a prominent retention of the cell surface p185c-erbB-2. In this study we compared the proliferation rate, the anchorage-independent growth, the secretion of matrix metalloproteases and of the urokinase-type plasminogen activator. The clones expressing the c-erbB-2 single-chain antibody, the control cells harbouring the empty vector and the parental SK-OV-3 cells they all had similar proliferation rates in the presence of 10% serum and secreted similar amounts of matrix metalloproteases and of the urokinase-type plasminogen activator. However, the expression of the c-erbB-2 oncogene product offers a strong growth advantage under serum-reduced conditions with 1% serum. In contrast to the parental SK-OV-3 and empty vector control cells, the scFv-5R-expressing clones were not able to grow anchorage-independently. These findings suggest that c-erbB-2 enhances transformation abilities of SK-OV-3 ovarian cancer cells without affecting the secretion of proteases and the proliferation of SK-OV-3 ovarian cancer cells in the presence of high concentrations of serum. © 1999 Cancer Research Campaig
- …