Spin-dependent Quantum Interference in Single-Wall Carbon Nanotubes with Ferromagnetic Contacts

We report the experimental observation of spin-induced magnetoresistance in single-wall carbon nanotubes contacted with high-transparency ferromagnetic electrodes. In the linear regime the spin-induced magnetoresistance oscillates with gate voltage in quantitative agreement with calculations based on a Landauer-Buttiker model for independent electrons. Consistent with this interpretation, we find evidence for bias-induced oscillation in the spin-induced magnetoresistance signal on the scale of the level spacing in the nanotube. At higher bias, the spin-induced magnetoresistance disappears because of a sharp decrease in the effective spin-polarization injected from the ferromagnetic electrodes.Comment: Replaced with published versio

Cell line derived xenograft mouse models are a suitable in vivo model for studying tumor budding in colorectal cancer

Tumor budding (TB) is an important prognostic parameter in colorectal cancer (CRC) and associated with metastasis. However, the mechanisms of TB have not been fully elucidated and a major limitation is the absence of in vivo models. Here, we determine the suitability of human cell line derived xenografts (CDX) as models of TB in CRC. Pan-cytokeratin (CK)-stained next-generation Tissue Microarrays (ngTMA) of two CDX models (HT-29, n = 12 and HCT-8, n = 8) and human CRC (n = 27 high-grade and 25 low-grade budding tumors, each) were evaluated for TB. Immunohistochemistry for E-cadherin, β-catenin, Ki-67, ZEB1, and TWIST1 was performed. HT-29 and HCT-8 were predominantly high-grade and no/low-grade TB tumors, respectively. TB counts in the tumor center (intratumoral budding, ITB) were significantly higher in HT-29 CDX tumors compared to human CRC (p = 0.0099). No difference was found in TB counts at the invasion front (peritumoral budding, PTB; p=0.07). ITB and PTB were strongly correlated (r = 0.438 and r = 0.62 in CDX and human CRC, respectively). Immunohistochemistry profiles were comparable in CDX and human CRC tissues. TB in the CDX mouse models is phenotypically similar to human CRCs and highlights comparable protein profiles. The HT-29 CDX could be a suitable model for the in vivo assessment of TB.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Effects of Grassland Management on Herbage Lipid Composition and Consequences for Fatty Acids in Milk

Herbage provides bulk feed and is the basis for ruminant nutrition. Herbage lipids, especially C18:3, are a major source of beneficial fatty acids (FA) in milk. These desired FA are unsaturated FA such as CLA (conjugated linoleic acid), especially the isomer rumenic acid, and also vaccenic acid, both trans omega-7 FA (Ellen & Elgersma, 2004). As information on lipids in forages is scarce, effects were studied of N application level and regrowth period on the lipid concentration and FA composition of perennial ryegrass (Lolium perenne L.), the most important forage in temperate climate zones. A linear relation had previously been found between C18:3 intake of cows stall-fed with fresh grass and the amount of omega-7 FA in milk (Elgersma et al., 2003)

The State-of-the-Art of Collaborative Technologies for Initial Vocational Education: A Systematic Literature Review

Future workplaces require collaboration skills in which members of different work communities use technologies to solve complex problems. Vocational education and training (VET) programs need to meet the challenge to prepare students to be part of a competent workforce. Particularly initial vocational education is under pressure to develop learners’ collaboration skills and abilities. To date, however, no attempt has been made to perform a comprehensive review of the use of computer-supported collaborative learning (CSCL) technologies across different vocational education settings to account for contextual factors of VET. In this systematic review, 26 published studies were analyzed with respect to their demographics, research methodology, use of technology, and measured outcomes. This review illuminates that research on CSCL still leaves the vocational learning context as an under-represented field of study. At the same time, technologies offer a range of new types of learning possibilities for vocational education. As the direct result of that development, vocational education is increasingly taking place in new technology-enhanced learning settings. Education can benefit from the opportunities of CSCL technologies, but on the other hand, such technologies create new challenges for facilitating vocational learning. Therefore, this review also identifies three topic areas specific to vocational learning (collaborative writing-to-learn, simulations and game-like solutions, and tangible objects) and enumerates desirable lines for future research

Fracture et déclenchement des avalanches de plaque : conditions critiques pour la propagation de la fracture

International audienceThe failure of a weak snow layer buried below cohesive slab layers is a necessary, but insufficient, condition for the release of a dry-snow slab avalanche. The size of the crack in the weak layer must also exceed a critical length to propagate across a slope. In contrast to pioneering shear-based approaches, recent developments account for weak layer collapse and allow for better explaining typical observations of remote triggering from low-angle terrain. However, these new models predict a critical length for crack propagation that is almost independent of slope angle, a rather surprising and counterintuitive result. Based on discrete element simulations we propose a new analytical expression for the critical crack length. This new model reconciles past approaches by considering for the first time the complex interplay between slab elasticity and the mechanical behavior of the weak layer including its structural collapse. The crack begins to propagate when the stress induced by slab loading and deformation at the crack tip exceeds the limit given by the failure envelope of the weak layer. The model can reproduce crack propagation on low-angle terrain and the decrease in critical length with increasing slope angle as modeled in numerical experiments. The good agreement of our new model with extensive field data and the ease of implementation in the snow cover model SNOWPACK opens a promising prospect for improving avalanche forecasting

The crazy-paving pattern: a radiological-pathological correlation

The crazy-paving pattern is a linear pattern superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is initially described as the pathognomonic sign of alveolar proteinosis. Nowadays this pattern is a common finding on high-resolution CT imaging, and can be seen in a number of acute and chronic diseases. The purpose of this paper is to illustrate different diseases that cause this crazy-paving pattern and to correlate the radiological findings from computed tomography with the histopathological findings