Body size and the risk of biliary tract cancer: a population-based study in China

Though obesity is an established risk factor for gall bladder cancer, its role in cancers of the extrahepatic bile ducts and ampulla of Vater is less clear, as also is the role of abdominal obesity. In a population-based case–control study of biliary tract cancer in Shanghai, China, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for biliary tract cancer in relation to anthropometric measures, including body mass index (BMI) at various ages and waist-to-hip ratio (WHR), adjusting for age, sex, and education. The study included 627 patients with biliary tract cancer (368 gall bladder, 191 bile duct, 68 ampulla of Vater) and 959 healthy subjects randomly selected from the population. A higher BMI at all ages, including early adulthood (ages 20–29 years), and a greater WHR were associated with an increased risk of gall bladder cancer. A high usual adult BMI (⩾25) was associated with a 1.6-fold risk of gall bladder cancer (95% CI 1.2–2.1, P for trend <0.001). Among subjects without gallstones, BMI was also positively associated with gall bladder cancer risk. Regardless of BMI levels, increasing WHR was associated with an excess risk of gall bladder cancer risk, with those having a high BMI (⩾25) and a high WHR (>0.90) having the highest risk of gall bladder cancer (OR=12.6, 95% CI 4.8–33.2), relative to those with a low BMI and WHR. We found no clear risk patterns for cancers of the bile duct and ampulla of Vater. These results suggest that both overall and abdominal obesity, including obesity in early adulthood, are associated with an increased risk of gall bladder cancer. The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai

Improved Imputation of Common and Uncommon Single Nucleotide Polymorphisms (SNPs) with a New Reference Set

Statistical imputation of genotype data is an important technique for analysis of genome-wide association studies (GWAS). We have built a reference dataset to improve imputation accuracy for studies of individuals of primarily European descent using genotype data from the Hap1, Omni1, and Omni2.5 human SNP arrays (Illumina). Our dataset contains 2.5-3.1 million variants for 930 European, 157 Asian, and 162 African/African-American individuals. Imputation accuracy of European data from Hap660 or OmniExpress array content, measured by the proportion of variants imputed with R^2^&#x3e;0.8, improved by 34%, 23% and 12% for variants with MAF of 3%, 5% and 10%, respectively, compared to imputation using publicly available data from 1,000 Genomes and International HapMap projects. The improved accuracy with the use of the new dataset could increase the power for GWAS by as much as 8% relative to genotyping all variants. This reference dataset is available to the scientific community through the NCBI dbGaP portal. Future versions will include additional genotype data as well as non-European populations

Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China

Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, biliary stone cases without evidence of cancer, and healthy subjects in a large population-based case-control study in Shanghai, China

Fast polynomial inversion for post quantum QC-MDPC cryptography

The NIST PQC standardization project evaluates multiple new designs for post-quantum Key Encapsulation Mechanisms (KEMs). Some of them present challenging tradeoffs between communication bandwidth and computational overheads. An interesting case is the set of QC-MDPC based KEMs. Here, schemes that use the Niederreiter framework require only half the communication bandwidth compared to schemes that use the McEliece framework. However, this requires costly polynomial inversion during the key generation, which is prohibitive when ephemeral keys are used. One example is BIKE, where the BIKE-1 variant uses McEliece and the BIKE-2 variant uses Niederreiter. This paper shows an optimized constant-time polynomial inversion method that makes the computation costs of BIKE-2 key generation tolerable. We report a speedup of 11.8x over the commonly used NTL library, and 55.5 over OpenSSL. We achieve additional speedups by leveraging the latest Intel\u27s Vector-PCLMULQDQ instructions on a laptop machine, 14.3x over NTL and 96.8x over OpenSSL. With this, BIKE-2 becomes a competitive variant of BIKE

Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study.

Background: Although most epidemiological studies suggest that non-steroidal anti-inflammatory drug use is inversely associated with prostate cancer risk, the magnitude and specificity of this association remain unclear. Methods: We examined self-reported aspirin and ibuprofen use in relation to prostate cancer risk among 29 450 men ages 55–74 who were initially screened for prostate cancer from 1993 to 2001 in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Men were followed from their first screening exam until 31 December 2009, during which 3575 cases of prostate cancer were identified. Results: After adjusting for potential confounders, the hazard ratios (HRs) of prostate cancer associated with \u3c1 and 1 pill of aspirin daily were 0.98 (95% confidence interval (CI), 0.90–1.07) and 0.92 (95% CI: 0.85–0.99), respectively, compared with never use (P for trend 0.04). The effect of taking at least one aspirin daily was more pronounced when restricting the analyses to men older than age 65 or men who had a history of cardiovascular-related diseases or arthritis (HR (95% CI); 0.87 (0.78–0.97), 0.89 (0.80–0.99), and 0.88 (0.78–1.00), respectively). The data did not support an association between ibuprofen use and prostate cancer risk. Conclusion: Daily aspirin use, but not ibuprofen use, was associated with lower risk of prostate cancer risk

The Pan-STARRS 1 discoveries of five new neptune trojans

In this work we report the detection of seven Neptune Trojans (NTs) in the Pan-STARRS 1 (PS1) survey. Five of these are new discoveries, consisting of four L4 Trojans and one L5 Trojan. Our orbital simulations show that the L5 Trojan stably librates for only several million years. This suggests that the L5 Trojan must be of recent capture origin. On the other hand, all four new L4 Trojans stably occupy the 1:1 resonance with Neptune for more than 1 Gyr. They can, therefore, be of primordial origin. Our survey simulation results show that the inclination width of the Neptune Trojan population should be between $7^{\circ}$ and $27^{\circ}$ at $>$ 95% confidence, and most likely $\sim 11^{\circ}$. In this paper, we describe the PS1 survey, the Outer Solar System pipeline, the confirming observations, and the orbital/physical properties of the new Neptune Trojans.Comment: 24 pages, 6 figures, AJ accepte