1,219 research outputs found
Місто як екзистенційна пастка (на матеріалі сучасної поезії)
Осмислюється специфіка екзистенційно зумовленого сприймання урбаністичного
простору в творчості сучасних українських поетів. Окреслюється своєрідне осмислення символів
дороги, лабіринту, човна, мосту, що є елементами просторової символіки художнього світу.
Стверджується, що урбаністичний простір сприймається сучасними митцями як екзистенцій на
пастка, духовно мертвий простір “недоіснування”, вихід з якого потребує духовного зусилля.
Ключові слова: хронотоп, топос, екзистенційний, ліричний герой, постмодернізм, символ.Осмысливается специфика экзистенциально преопределенного восприятия
урбанистического пространства в творчестве современных украинских поэтов. Анализируется
своеобразное осмысление символов дороги, лабиринта, лодки, моста, который является
элементами пространственной символики художественного мира. Утверждается, что
урбанистическое пространство воспринимается современными художниками как
экзистенциальная ловушка, духовно мертвое пространство “недосуществования”, выход из
которого требует в духовном усилии.
Ключевые слова: хронотоп, топос, экзистенциальный, лирический герой,
постмодернизм, символ.A specific is comprehended ekzistenciаl the predefined perception of urbanism space in
creation of the modern Ukrainian poets. The original comprehension of symbols of road, labyrinth, boat,
bridge which is the elements of spatial symbolism of the artistic world is outlined. It becomes firmly
established that urbanism space is perceived modern artists as ekzistencial on trap, spiritually dead
ground, an exit from which needs spiritual effort.
Keywords: khronotop, topos, ekzistencial, lyric hero, postmodernizm, symbol
Why quiet reflection improves development performance
__Abstract__
No-cost, easy-to-deploy ways for increasing development
productivity have now been successfully tested in and out of the
lab. R&D managers, meeting facilitators and anyone interested
in idea generation, take note
Estimating the number needed to treat from continuous outcomes in randomised controlled trials: methodological challenges and worked example using data from the UK Back Pain Exercise and Manipulation (BEAM) trial
Background
Reporting numbers needed to treat (NNT) improves interpretability of trial results. It is unusual that continuous outcomes are converted to numbers of individual responders to treatment (i.e., those who reach a particular threshold of change); and deteriorations prevented are only rarely considered. We consider how numbers needed to treat can be derived from continuous outcomes; illustrated with a worked example showing the methods and challenges.
Methods
We used data from the UK BEAM trial (n = 1, 334) of physical treatments for back pain; originally reported as showing, at best, small to moderate benefits. Participants were randomised to receive 'best care' in general practice, the comparator treatment, or one of three manual and/or exercise treatments: 'best care' plus manipulation, exercise, or manipulation followed by exercise. We used established consensus thresholds for improvement in Roland-Morris disability questionnaire scores at three and twelve months to derive NNTs for improvements and for benefits (improvements gained+deteriorations prevented).
Results
At three months, NNT estimates ranged from 5.1 (95% CI 3.4 to 10.7) to 9.0 (5.0 to 45.5) for exercise, 5.0 (3.4 to 9.8) to 5.4 (3.8 to 9.9) for manipulation, and 3.3 (2.5 to 4.9) to 4.8 (3.5 to 7.8) for manipulation followed by exercise. Corresponding between-group mean differences in the Roland-Morris disability questionnaire were 1.6 (0.8 to 2.3), 1.4 (0.6 to 2.1), and 1.9 (1.2 to 2.6) points.
Conclusion
In contrast to small mean differences originally reported, NNTs were small and could be attractive to clinicians, patients, and purchasers. NNTs can aid the interpretation of results of trials using continuous outcomes. Where possible, these should be reported alongside mean differences. Challenges remain in calculating NNTs for some continuous outcomes
Depletion sensitivity predicts unhealthy snack purchases
The aim of the present research is to examine the relation between depletion sensitivity - a novel construct referring to the speed or ease by which one's self-control resources are drained - and snack purchase behavior. In addition, interactions between depletion sensitivity and the goal to lose weight on snack purchase behavior were explored. Participants included in the study were instructed to report every snack they bought over the course of one week. The dependent variables were the number of healthy and unhealthy snacks purchased. The results of the present study demonstrate that depletion sensitivity predicts the amount of unhealthy (but not healthy) snacks bought. The more sensitive people are to depletion, the more unhealthy snacks they buy. Moreover, there was some tentative evidence that this relation is more pronounced for people with a weak as opposed to a strong goal to lose weight, suggesting that a strong goal to lose weight may function as a motivational buffer against self-control failures. All in all, these findings provide evidence for the external validity of depletion sensitivity and the relevance of this construct in the domain of eating behavior.</p
Can prolonged sick leave after gynecologic surgery be predicted? An observational study in the Netherlands
BACKGROUND: Sick leave frequently has been used as an outcome to evaluate minimal invasive surgery compared with conventional open surgery. However, sick leave is determined not only by the surgical approach. Recently, a postoperative recovery-specific quality-of-life questionnaire, the Recovery Index (RI-10), has been developed and validated. This study investigated the relation of the Recovery Index 10, the RI-6 (a subset of 6 questions), and the type of surgery to sick leave. METHODS: The study enrolled 46 patients with a paid job scheduled for elective gynecologic surgery, who filled out the RI-10. After 8 weeks, the patients were approached by telephone to give information on their return to work. RESULTS: Of the 46 patients, 23 (50%) returned to work completely after 8 weeks, 14 (30%) resumed work partly, and 9 (20%) did not resume work at all. In the analysis, the patients who completely returned to work were compared with those who did not return or partially returned. Recovery as expressed in the RI-6 improved with time after surgery. It appeared that the measurement 2 weeks after surgery showed the best discriminative capacity to predict sick leave after 8 weeks, with an area under the curve of 0.88 (confidence interval, 0.74-1.03). The subjective postoperative recovery as expressed by the RI-6 is more closely related to the type of surgery (p = 0.001) sick leave is (p = 0.14). CONCLUSIONS: The subjective recovery scored by the patient on a questionnaire of six questions is a better outcome than sick leave for evaluating surgical approaches. If administered 2 weeks after surgery, it may predict prolonged sick leav
Dynamic compartmentalization of bacteria: accurate division in E. coli
Positioning of the midcell division plane within the bacterium E. coli is
controlled by the min system of proteins: MinC, MinD and MinE. These proteins
coherently oscillate from end to end of the bacterium. We present a
reaction--diffusion model describing the diffusion of min proteins along the
bacterium and their transfer between the cytoplasmic membrane and cytoplasm.
Our model spontaneously generates protein oscillations in good agreement with
experiments. We explore the oscillation stability, frequency and wavelength as
a function of protein concentration and bacterial length.Comment: 4 pages, 4 figures, Latex2e, Revtex
Surgeons’ preferences for using sentinel lymph node biopsy in patients with ductal carcinoma in situ
BACKGROUND: There is a large variation between Dutch hospitals in the use of Sentinel Lymph Node Biopsy (SLNB) in patients with a biopsy diagnosis of Ductal Carcinoma in Situ. The aim of our study was to investigate whether this variation might be explained by preferences of surgeons, organisational factors or the influence of patients preferences. METHODS: A cross-sectional web survey was conducted among 260 Dutch oncological/breast surgeons. Preferences of surgeons and the influence of the patients’ preferences were determined by means of best-worst scaling (BWS) of profile case scenarios and by ranking risk factors. The survey also explored organisational questions, the reported use of diagnostic techniques and influences on the decision. RESULTS: The BWS scenarios were completed by 57 surgeons. The most important reasons for performing SLNB were a suspected invasive component and DCIS grade 3. In the ranking, these were also the first and second most important factor, followed by the size of the lesion and a mass on mammogram. In 58% to 70% of the scenarios, the surgeons would not change their decisions on the use of SLNB if the patient’s chose differed. No organisational factor was significantly associated with the reported use of SLNB. CONCLUSION: The inter-hospital variation in the use of SLNB could not be attributed to organisational factors or surgeons’ preferences for risk factors. The risk factors that most surgeons reported as reasons for performing SLNB are consistent with the factors described in the Dutch treatment guideline for the use of SLNB
“Четвертий поділ” Польщі і встановлення радянського тоталітарного режиму в Західній Україні
The present article was based on the unknown documents of the Branch state archive of Security service of Ukraine and showed the first phase so called “sovietizashion” (establishment of Soviet regim) of Western Ukraine after being joined to the USSR in the September 1939. The author investigeted the measures used to arrange the 800-meter borderland between the USSR and Third Reich
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