Online tracking: Questioning the power of informed consent

Online tracking technologies have raised considerable concerns regarding privacy and the protection of personal data of users. In order to help users to regain control over their personal data, Europe has amended its ePrivacy directive towards an opt-in regime. There are however many open questions concerning its implementation, especially regarding the issue of informed consent. This paper explores how the new legal situation impacts on behavioral advertising practices via the storing and reading of cookies in the Netherlands. The results show that the majority of the surveyed parties involved in behavioural advertising do not inform users about the storing of cookies or the purposes of data processing of the subsequently obtained data, neither do they have obtained users' consent for the storage of cookies. We also found that the majority of users lack the skills and knowledge how to handle cookies. These findings critically question the wisdom of the informed consent regime which lies currently at the heart of Europe's ePrivacy directive. --Online behavioural advertising,profiling,cookies,informed consent,Do Not Track,ePrivacy Directive

Review of clinical, cytogenetic, and molecular aspects of Ph-negative CML

Abstract Between 1985 and 1989, many cases of Philadelphia (Ph) chromosome negative chronic myelogenous leukemia (CML) were reported. For this review, the following selection criteria were used: the original articles on Ph-negative cases should provide clinical, hematologic, cytogenetic as well as molecular data. In addition, eight unpublished cases of Ph-negative CML are included that were studied in our institute during the last two years. Our purpose was to correlate presence or absence of the Ph rearrangement with the clinical features in an attempt to test whether the entity “Ph-negative CML” really exists and to identify the pathologic characteristics, frequency of occurrence, prognosis for survival, and underlying molecular mechanisms. Data on Ph-negative CML patients were compared with data on Ph-positive CML, atypical CML (aCML), and chronic myelomonocytic leukemia (CMMoL), reported in the same papers as the Ph negative patients. Essential for comparison of data from the different investigators appeared to be a clear description of criteria they used to establish the diagnosis CML, or alternatively a complete presentation of data for all patients reported in the articles. In most cases. Ph-negative CML was distinguishable from CMMoL and aCML, using simple criteria, e.g., differential count of peripheral blood and absence of dysplasia in the bone marrow. Cytogenetic analysis showed normal karyotype in most cases of Ph-negative CML. Interestingly, in cases with abnormal karyotype, chromosome 9 band q34 was relatively frequently involved in translocations with other chromosomes than chromosome 22, suggesting a variant Ph translocation not visible by cytogenetic techniques. This assumption was confirmed by molecular analysis, demonstrating bcr-abl rearrangement in 9 out of 10 of the latter cases. Results of cytogenetic and molecular investigations in 136 cases of Ph-negative CML reviewed in this article clearly indicated that molecular techniques are valuable tools for identification of bcr-abl rearrangements, indicative for the Ph translocation. The different mechanisms responsible for bcr-abl rearrangement in Ph-negative CML patients are discussed. The question remains whether all Ph-negative CML patients will have bcr-abl rearrangements, or whether alternative mechanisms will be identified that are responsible for this disease

Beyond Speculative Robot Ethics

In this article we develop a dialogue model for robot technology experts and designated users to discuss visions on the future of robotics in long-term care. Our vision assessment study aims for more distinguished and more informed visions on future robots. Surprisingly, our experiment also lead to some promising co-designed robot concepts in which jointly articulated moral guidelines are embedded. With our model we think to have designed an interesting response on a recent call for a less speculative ethics of technology by encouraging discussions about the quality of positive and negative visions on the future of robotics.

Observability of Forming Planets and their Circumplanetary Disks I. -- Parameter Study for ALMA

We present mock observations of forming planets with ALMA. The possible detections of circumplanetary disks (CPDs) were investigated around planets of Saturn, 1, 3, 5, and 10 Jupiter-masses that are placed at 5.2 AU from their star. The radiative, three dimensional hydrodynamic simulations were then post-processed with RADMC3D and the ALMA Observation Simulator. We found that even though the CPDs are too small to be resolved, they are hot due to the accreting planet in the optically thick limit, therefore the best chance to detect them with continuum observations in this case is at the shortest ALMA wavelengths, such as Band 9 (440 microns). Similar fluxes were found in the case of Saturn and Jupiter-mass planets, as for the 10 $\mathrm{M_{Jup}}$ gas-giant, due to temperature weighted optical depth effects: when no deep gap is carved, the planet region is blanketed by the optically thick circumstellar disk leading to a less efficient cooling there. A test was made for a 52 AU orbital separation, showed that optically thin CPDs are also detectable in band 7 but they need longer integration times ($>$5hrs). Comparing the gap profiles of the same simulation at various ALMA bands and the hydro simulation confirmed that they change significantly, first because the gap is wider at longer wavelengths due to decreasing optical depth; second, the beam convolution makes the gap shallower and at least 25% narrower. Therefore, caution has to be made when estimating planet masses based on ALMA continuum observations of gaps.Comment: Accepted for publication at MNRAS. Typos are corrected since previous version. 11 pages, 5 tables, 4 figure

Maggot Secretions Skew Monocyte-Macrophage Differentiation Away from a Pro-Inflammatory to a Pro-Angiogenic Type

Background: Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Earlier we reported maggot secretions to inhibit pro-inflammatory responses of human monocytes. The aim of this study was to investigate the effect of maggot secretions on the differentiation of monocytes into pro-inflammatory (MØ-1) and anti-inflammatory/proangiogenic macrophages (MØ-2) as these cells play a central role in wound healing. Methodology/Principal Findings: Freshly isolated monocytes were incubated with secretions and GM-CSF or M-CSF for 6 days and then stimulated with LPS or LTA for 18 h. The expression of cell surface molecules and the levels of cytokines, chemokines and growth factors in supernatants were measured. Our results showed secretions to affect monocytemacrophage differentiation leading to MØ-1 with a partial MØ-2-like morphology but lacking CD163, which is characteristic for MØ-2. In response to LPS or LTA, secretions-differentiated MØ-1 produced less pro-inflammatory cytokines (TNF-a, IL-12p40 and MIF) than control cells. Similar results were observed for MØ-2 when stimulated with low concentrations of LPS. Furthermore, secretions dose-dependently led to MØ-1 and MØ-2 characterized by an altered chemokine production. Secretions led to MØ-2, but not MØ-1, producing enhanced levels of the growth factors bFGF and VEGF, as compared to control cells. The expression of cell-surface receptors involved in LPS/LTA was enhanced by secretions, that of CD86 and HLA-DR down-regulated, while receptors involved in phagocytosis remained largely unaffected

Warm and hot circumstellar gas in V1647 Ori during the 2008-2009 outburst

The pre-main sequence star V1647 Ori started a new outburst in August 2008. From October 2008 to February 2009 we monitored V1647 Ori, obtaining quasi-simultaneous VLT-CRIRES near-IR spectroscopy, VLT-VISIR mid-IR spectroscopy and VLT-FORS2 optical spectroscopy. We studied the evolution of H2 and CO emission from hot and warm gas and Hα and forbidden line-emission during the initial outburst phase of V1647 Ori. Hα is observed in emission displaying P-Cygni profiles with blue-shifted absorption up to -700 km/s, suggesting the presence of a high velocity wind (Fig. 1a). [OI] emission at 6300 Å is observed displaying a blue-shifted emission shoulder, indicating the presence of material moving away from the star (Fig. 1b). We detect H2 1-0 S(1) and CO (P4 to P14 and P30-P38) ro-vibrational lines centered at the velocity of the star at all epochs (Fig. 1c & d). This strongly suggests that the H2 and CO emission originates from a disk and not from a warm outflow. The H2 1-0 S(0) and 2-1 S(1) ro-vibrational lines at 2.22 and 2.24 μm and the pure-rotational H2 0-0 S(1) and 0-0 S(2) lines at 17 and 12 μm were not detected in our spectra. Changes in the Hα and [OI] profiles and the H2 and CO emission observed do not correlate. We modeled the H2 and CO line profiles assuming emission from a flat disk in keplerian rotation with line intensity decreasing with radius (I ~ I0(R/Rmin)−α). We found that the disk of V1647 Ori is observed nearly face-on and that the line emission is produced within a fraction of an AU of the star (Fig. 1d