5 research outputs found
EUROPEAN INITIATIVE “STENT FOR LIFE” IN RUSSIA
- Publication venue
- 'Silicea - Poligraf, LLC'
- Publication date
- 01/06/2016
- Field of study
The article presents data on implementation of European Initiative “Stent for Life” (modern system of care organization for myocardial infarction patients) inRussian Federation
Problems of psychophysiological status of human capital in the cyclic conditions of Arctic
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Chronobiological potential of human resources as a condition for ensuring socially safe activities in the development of the North
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Mean age of death and longevity for male scientists of different specialties
- Author
- A. Lager
- A. Steptoe
- A.S. Bashkireva
- B.J. Willcox
- C. Franceschi
- D.A. Redelmeier
- E.I. Puchkova
- E.J. Gumbel
- E.M. Andreev
- G. M. Zharinov
- G. Steen
- G.M. Zharinov
- G.M. Zharinov
- J. Mitteldorf
- K. Yaffe
- K.E. Shin
- M.-F. Schulz-Aellen
- N. Adler
- N.B. Man’kovskii
- P.Yu. Shmidt
- R. Fitzpatrick
- R.M. Kaplan
- S. Kanazawa
- S. Sri Kantha
- T. Robertson
- V. N. Anisimov
- V.G. Berezkin
- V.N. Anisimov
- V.N. Anisimov
- V.N. Anisimov
- V.N. Anisimov
- V.N. Anisimov
- V.N. Anisimov
- W.C. Coates
- Publication venue
- 'Allerton Press'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- AraĂşjo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
- Ausperger KM
- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
- Ayasse D
- Ayau Milla O
- Ayesu K
- Aylward P
- Azhdari M
- Azua MG
- Babbar A
- Babbolin M
- Babilonia N
- Babilonia N
- Babu P
- Babu R
- Babuty D
- Badenhorst J
- Badila E
- Bae HJ
- Bagatin J
- Bagby J
- Bai F
- Baine S
- Bakliza Z
- Balboa W
- Baldwin E
- Ball E
- Ballyuzek M
- Baman R
- Bamhorst M
- Bamrungpong P
- Banaeian F
- Banikova A
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- Barnhorst M
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- Barrington P
- Barros R
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- Bart B
- Bartholomaus D
- Bartkowiak A
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- Bashkireva A
- Basson M
- Baszak J
- Baszak J
- Batchell K
- Batista M
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- Battistelli E
- Batushkin V
- Bauch F
- Bauch F
- Bauer K
- Bautista C
- Bayata S
- Bayata S
- Baylacher M
- Bayram Llamas E
- Bazylevych A
- Beasley R
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- Beeton I
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- Belatsky V
- Belcuore M
- Belenky D
- Belhassane A
- Beloscar J
- Belousova L
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- Benatar J
- Bengtsson AS
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- Bentivenga L
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- Berbari H
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- Bereznyakov I
- Berger CJ
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- Borowski W
- Borsheim M
- Borthwick L
- Bosco B
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- Bossaers J
- Botelho R
- Botero R
- Botha L
- Bouchard A
- Bourlios P
- Boursin P
- Bouzo M
- Bowden W
- Bowen L
- Bowman B
- Boyer M
- Bozek B
- Bradley A
- Braemer U
- Braun D
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- Braunwald E
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- Bridge C
- Brilakis E
- Briscoe C
- Broberg M
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- Bronisz M
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- Bugueño C
- Buhler A
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- Buiks C
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- Builes A
- Buksa B
- Bulgari M
- Bulygin S
- Burianova H
- Burianova H
- Bush D
- Bustamante G
- Bustamante Labarta G
- Busz-Papiez B
- Butcher S
- Buza V
- Buzzetti C
- Bybee K
- Cabero P
- Cabrera J
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- Calambur N
- Calderon M
- Calik A
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- Capiau L
- Caplan J
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- Carrion A
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- Chaturvedi S
- Chaves Junior H
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- Chen YF
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- Cheng CC
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- Chernyavskaya T
- Cherrico M
- Chiang CE
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- Chilvers M
- Chiou CW
- Chiu CZ
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- Choi KJ
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- Chompalova B
- Chopda M
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- Christensen H
- Christensen L
- Christian T. Ruff
- Chumakova G
- Chun MY
- Chung A
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- Ciaramita J
- Cieslak B
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- Ciobotaru G
- Ciortea M
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- Claussen H
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- Ĺśpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)