Radio Astronomical Polarimetry and Point-Source Calibration

A mathematical framework is presented for use in the experimental determination of the polarimetric response of observatory instrumentation. Elementary principles of linear algebra are applied to model the full matrix description of the polarization measurement equation by least-squares estimation of non-linear, scalar parameters. The formalism is applied to calibrate the center element of the Parkes Multibeam receiver using observations of the millisecond pulsar, PSR J0437-4715, and the radio galaxy, 3C 218 (Hydra A).Comment: 8 pages, 4 figures, to be published in ApJ

Machine learning potential for the Cu-W system

Combining the excellent thermal and electrical properties of Cu with the high abrasion resistance and thermal stability of W, Cu-W nanoparticle-reinforced metal matrix composites and nano-multilayers (NMLs) are finding applications as brazing fillers and shielding material for plasma and radiation. Due to the large lattice mismatch between fcc Cu and bcc W, these systems have complex interfaces that are beyond the scales suitable for ab initio methods, thus motivating the development of chemically accurate interatomic potentials. Here, a neural network potential (NNP) for Cu-W is developed within the Behler-Parrinello framework using a curated training dataset that captures metallurgically-relevant local atomic environments. The Cu-W NNP accurately predicts (i) the metallurgical properties (elasticity, stacking faults, dislocations, thermodynamic behavior) in elemental Cu and W, (ii) energies and structures of Cu-W intermetallics and solid solutions, and (iii) a range of fcc Cu/bcc W interfaces, and exhibits physically-reasonable behavior for solid W/liquid Cu systems. As will be demonstrated in forthcoming work, this near-ab initio-accurate NNP can be applied to understand complex phenomena involving interface-driven processes and properties in Cu-W composites.Comment: Submitted, yet unpublishe

Full Stokes polarimetric observations with a single-dish radio-telescope

The study of the linear and circular polarization in AGN allows one to gain detailed information about the properties of the magnetic fields in these objects. However, especially the observation of circular polarization (CP) with single-dish radio-telescopes is usually difficult because of the weak signals to be expected. Normally CP is derived as the (small) difference of two large numbers (LHC and RHC); hence an accurate calibration is absolutely necessary. Our aim is to improve the calibration accuracy to include the Stokes parameter V in the common single-dish polarimetric measurements, allowing a full Stokes study of the source under examination. A detailed study, up to the 2nd order, of the Mueller matrix elements in terms of cross-talk components allows us to reach the accuracy necessary to study circular polarization. The new calibration method has been applied to data taken at the 100-m Effelsberg radio-telescope during regular test observations of extragalactic sources at 2.8, 3.6, 6 and 11 cm. The D-terms in phase and amplitude appear very stable with time and the few known values of circular polarization have been confirmed. It is shown that, whenever a classical receiver and a multiplying polarimeter are available, the proposed calibration scheme allows one to include Stokes V in standard single-dish polarimetric observations as difference of two native circular outputs.Comment: 10 pages, to be published in A&

Mesenchymal Stromal Cell secretome is affected by tissue source and donor age.

Variation in Mesenchymal Stromal Cell (MSC) function depending on their origin is problematic, as it may confound clinical outcomes of MSC therapy. Current evidence suggests that the therapeutic benefits of MSCs are attributed to secretion of biologically active factors (secretome). However, the effect of donor characteristics on the MSC secretome remains largely unknown. Here, we examined the influence of donor age, sex and tissue source, on the protein profile of the equine MSC secretome. We used dynamic metabolic labelling with stable isotopes combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify secreted proteins in MSC conditioned media (CM). Seventy proteins were classified as classically-secreted based on the rate of label incorporation into newly synthesised proteins released into the extracellular space. Next, we analysed CM of bone marrow- (n = 14) and adipose-derived MSCs (n = 16) with label-free LC-MS/MS. Clustering analysis of 314 proteins detected across all samples identified tissue source as the main factor driving variability in MSC CM proteomes. Linear modelling applied to the subset of 70 secreted proteins identified tissue-related difference in the abundance of 23 proteins. There was an age-related decrease in the abundance of CTHRC1 and LOX, further validated with orthogonal techniques. Due to the lack of flow cytometry characterisation of MSC surface markers, the analysis could not account for the potential effect of cell population heterogeneity. This study provides evidence that tissue source and donor age contribute to differences in the protein composition of MSC secretomes which may influence the effects of MSC therapy

Uncovering the origin of interface stress enhancement and compressive-to-tensile stress transition in immiscible nanomultilayers

The intrinsic stress in nanomultilayers (NMLs) is typically dominated by interface stress, which is particularly high in immiscible Cu/W NMLs. Here, atomistic simulations with a chemically-accurate neural network potential reveal the role of interfacial intermixing and metastable phase formation on the interface stress levels. These results rationalize an experimentally-reported compressive- to-tensile transition as a function of NML deposition conditions and the extremely high interface stresses under some conditions