Quadratic Mixing of Radio Frequency Signals using Superconducting Quantum Interference Filters

The authors demonstrate quadratic mixing of weak time harmonic electromagnetic fields applied to Superconducting Quantum Interference Filters, manufactured from high-$T_{\mathrm{c}}$ grain boundary Josephson junctions and operated in active microcooler. The authors use the parabolic shape of the dip in the dc-voltage output around B=0 to mix \emph{quadratically} two external rf-signals, at frequencies $f_{\mathrm{1}}$ and $f_{\mathrm{2}}$ well below the Josephson frequency $f_{\mathrm{J}}$, and detect the corresponding mixing signal at $| {f_{1}-f_{2}}|$. Quadratic mixing takes also place when the SQIF is operated without magnetic shield. The experimental results are well described by a simple analytical model based on the adiabatic approximation.Comment: 3 pages, 3 figure

High performance magnetic field sensor based on Superconducting Quantum Interference Filters

We have developed an absolute magnetic field sensor using Superconducting Quantum Interference Filter (SQIF) made of high-T_c grain boundary Josephson junctions. The device shows the typical magnetic field dependent voltage response V(B), which is sharp delta-like dip in the vicinity of zero magnetic field. When the SQIF is cooled with magnetic shield, and then the shield is removed, the presence of the ambient magnetic field induces a shift of the dip position from B_0 ~ 0 to a value B ~ B_1, which is about the average value of the earth magnetic field, at our latitude. When the SQIF is cooled in the ambient field without shielding, the dip is first found at B ~ B_1, and the further shielding of the SQIF results in a shift of the dip towards B_0 ~ 0. The low hysteresis observed in the sequence of experiments (less than 5% of B_1) makes SQIFs suitable for high precision measurements of the absolute magnetic field. The experimental results are discussed in view of potential applications of high-T_c SQIFs in magnetometry.Comment: 4 pages, 2 figure

Observation of Spontaneous Brillouin Cooling

While radiation-pressure cooling is well known, the Brillouin scattering of light from sound is considered an acousto-optical amplification-only process. It was suggested that cooling could be possible in multi-resonance Brillouin systems when phonons experience lower damping than light. However, this regime was not accessible in traditional Brillouin systems since backscattering enforces high acoustical frequencies associated with high mechanical damping. Recently, forward Brillouin scattering in microcavities has allowed access to low-frequency acoustical modes where mechanical dissipation is lower than optical dissipation, in accordance with the requirements for cooling. Here we experimentally demonstrate cooling via such a forward Brillouin process in a microresonator. We show two regimes of operation for the Brillouin process: acoustical amplification as is traditional, but also for the first time, a Brillouin cooling regime. Cooling is mediated by an optical pump, and scattered light, that beat and electrostrictively attenuate the Brownian motion of the mechanical mode.Comment: Supplementary material include

Stability of Resonant Opto-Mechanical Oscillators

We theoretically study the frequency stability of an opto-mechanical radio frequency oscillator based on resonant interaction of two optical and one mechanical modes of the same optical microcavity. A generalized expression for the phase noise of the oscillator is derived using Langevin formalism and compared to the phase noise of existing electronic oscillators.Comment: 6 pages, 1 figur

Dynamics of SNARE Assembly and Disassembly during Sperm Acrosomal Exocytosis

The dynamics of SNARE assembly and disassembly during membrane recognition and fusion is a central issue in intracellular trafficking and regulated secretion. Exocytosis of sperm's single vesicle—the acrosome—is a synchronized, all-or-nothing process that happens only once in the life of the cell and depends on activation of both the GTP-binding protein Rab3 and of neurotoxin-sensitive SNAREs. These characteristics make acrosomal exocytosis a unique mammalian model for the study of the different phases of the membrane fusion cascade. By using a functional assay and immunofluorescence techniques in combination with neurotoxins and a photosensitive Ca(2+) chelator we show that, in unactivated sperm, SNAREs are locked in heterotrimeric cis complexes. Upon Ca(2+) entry into the cytoplasm, Rab3 is activated and triggers NSF/α-SNAP-dependent disassembly of cis SNARE complexes. Monomeric SNAREs in the plasma membrane and the outer acrosomal membrane are then free to reassemble in loose trans complexes that are resistant to NSF/α-SNAP and differentially sensitive to cleavage by two vesicle-associated membrane protein (VAMP)–specific neurotoxins. Ca(2+) must be released from inside the acrosome to trigger the final steps of membrane fusion that require fully assembled trans SNARE complexes and synaptotagmin. Our results indicate that the unidirectional and sequential disassembly and assembly of SNARE complexes drive acrosomal exocytosis

Effects of magnetic field on two-dimensional Superconducting Quantum Interference Filters

We present an experimental study of two-dimensional superconducting quantum interference filters (2D-SQIFs) in the presence of a magnetic field B. The dependences of the dc voltage on the applied magnetic field are characterized by a unique delta-like dip at B=0, which depends on the distribution of the areas of the individual loops, and on the bias current. The voltage span of the dip scales proportional to the number of rows simultaneously operating at the same working point. In addition, the voltage response of the 2D-SQIF is sensitive to a field gradient generated by a control line and superimposed to the homogeneous field coil. This feature opens the possibility to use 2D superconducting quantum interference filters as highly sensitive detectors of spatial gradients of magnetic field.Comment: 3 pages, 4 figures, submitted to AP

Beyond the edge: Markerless pose estimation of speech articulators from ultrasound and camera images using DeepLabCut

Automatic feature extraction from images of speech articulators is currently achieved by detecting edges. Here, we investigate the use of pose estimation deep neural nets with transfer learning to perform markerless estimation of speech articulator keypoints using only a few hundred hand-labelled images as training input. Midsagittal ultrasound images of the tongue, jaw, and hyoid and camera images of the lips were hand-labelled with keypoints, trained using DeepLabCut and evaluated on unseen speakers and systems. Tongue surface contours interpolated from estimated and hand-labelled keypoints produced an average mean sum of distances (MSD) of 0.93, s.d. 0.46 mm, compared with 0.96, s.d. 0.39 mm, for two human labellers, and 2.3, s.d. 1.5 mm, for the best performing edge detection algorithm. A pilot set of simultaneous electromagnetic articulography (EMA) and ultrasound recordings demonstrated partial correlation among three physical sensor positions and the corresponding estimated keypoints and requires further investigation. The accuracy of the estimating lip aperture from a camera video was high, with a mean MSD of 0.70, s.d. 0.56, mm compared with 0.57, s.d. 0.48 mm for two human labellers. DeepLabCut was found to be a fast, accurate and fully automatic method of providing unique kinematic data for tongue, hyoid, jaw, and lips.https://doi.org/10.3390/s2203113322pubpub

Hometronics – accessible production of graphene suspensions for health sensing applications using only household items

Nanoscience at times can seem out of reach to the developing world and the general public, with much of the equipment expensive and knowledge seemingly esoteric to nonexperts. Using only cheap, everyday household items, accessible research with real applications can be shown. Here, graphene suspensions were produced using pencil lead, tap water, kitchen appliances, soaps and coffee filters, with a children’s glue-based graphene nanocomposite for highly sensitive pulse measurements demonstrated