1,587 research outputs found
Australian newspaper blogs
Blogs have become one of the most prominent forms of social media on the Web. This paper reports on the first part of a comprehensive study of how a mainstream Australian media organisation is integrating blogs into their business. The research used a qualitative approach and data collection was undertaken using semi-structured interviews with newspaper staff. The findings presented provide an insight into the opportunities to be gained and the challenges to be faced by Australian media organisations as they incorporate blogs in their online offerings
Consistency Properties of Species Tree Inference by Minimizing Deep Coalescences
Methods for inferring species trees from sets of gene trees need to account for the possibility of discordance among the gene trees. Assuming that discordance is caused by incomplete lineage sorting, species tree estimates can be obtained by finding those species trees that minimize the number of -deep- coalescence events required for a given collection of gene trees. Efficient algorithms now exist for applying the minimizing-deep-coalescence (MDC) criterion, and simulation experiments have demonstrated its promising performance. However, it has also been noted from simulation results that the MDC criterion is not always guaranteed to infer the correct species tree estimate. In this article, we investigate the consistency of the MDC criterion. Using the multipscies coalescent model, we show that there are indeed anomaly zones for the MDC criterion for asymmetric four-taxon species tree topologies, and for all species tree topologies with five or more taxa.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90434/1/cmb-2E2010-2E0102.pd
An Investigation of Thai High School Students' English Language Learning Problems
A way to improve English language teaching is an investigation of students' English language problems. This study therefore explored Thai high school students' English language learning problems. This was a case study, employing a survey design and using a questionnaire as instrument for data collection. The subjects were 104 high school students in Lampang Province, Thailand. The results of this study revealed the following findings. On listening, the students had difficulty in class discussion in English. On speaking, they had trouble with asking questions in English in the classroom. On reading, they could not understand English idioms. On writing, they were unable to finish essay writing within a limited time. On sociocultural perspectives on second language learning, they lacked opportunity to spend time associate with native speakers. On International communication barriers, on oral presentation for a lesson assignment, they rehearsed it only 2-3 times to prepare themselves. Lastly, of all language learning tasks, the most problematic English task was writing. This study is a puzzle to the whole picture. Future inquiry should replicate this study to see the whole picture of this issue
Role of the Calcium Plateau in the Neuronal Injury and Behavioral Morbidities Following Organophosphate Intoxication
Organophosphate (OP) chemicals include nerve agents and pesticides, and there is a growing concern of OP based chemical attacks against civilians. Current antidotes are essential in limiting immediate mortality associated with OP exposure. However, further research is needed to identify molecular mechanisms underlying long-term neurological deficits following survival of OP toxicity in order to develop effective therapeutics. We have developed rat survival models of OP induced status epilepticus (SE) that mimic chronic mortality and morbidity following OP intoxication. We have observed significant elevations in hippocampal calcium levels after OP SE that persisted for weeks following initial survival. Drugs inhibiting intracellular calcium-induced calcium release such as dantrolene, levetiracetam, and carisbamate lowered OP-SE mediated protracted calcium elevations. Given the critical role of calcium signaling in modulating behavior and cell-death mechanisms, drugs targeted at preventing the development of the calcium plateau could enhance neuroprotection, help reduce morbidity and improve outcome following survival of OP SE
Recommended from our members
Quantifying Uncertainties in Sequential Chemical Extraction of Soil Phosphorus Using XANES Spectroscopy.
Sequential chemical extraction has been widely used to study soil phosphorus (P) dynamics and inform nutrient management, but its efficacy for assigning P into biologically meaningful pools remains unknown. Here, we evaluated the accuracy of the modified Hedley extraction scheme using P K-edge X-ray absorption near-edge structure (XANES) spectroscopy for nine carbonate-free soil samples with diverse chemical and mineralogical properties resulting from different degrees of soil development. For most samples, the extraction markedly overestimated the pool size of calcium-bound P (Ca-P, extracted by 1 M HCl) due to (1) P redistribution during the alkaline extractions (0.5 M NaHCO3 and then 0.1 M NaOH), creating new Ca-P via formation of Ca phosphates between NaOH-desorbed phosphate and exchangeable Ca2+ and/or (2) dissolution of poorly crystalline Fe and Al oxides by 1 M HCl, releasing P occluded by these oxides into solution. The first mechanism may occur in soils rich in well-crystallized minerals and exchangeable Ca2+ regardless of the presence or absence of CaCO3, whereas the second mechanism likely operates in soils rich in poorly crystalline Fe and Al minerals. The overestimation of Ca-P simultaneously caused underestimation of the pools extracted by the alkaline solutions. Our findings identify key edaphic parameters that remarkably influenced the extractions, which will strengthen our understanding of soil P dynamics using this widely accepted procedure
An Unusual Case of Hematochezia
Lower gastrointestinal bleeding (LGIB) is a serious and potentially life-threatening condition warranting hospital admission. The most frequent causes include diverticular disease, colitis, hemorrhoids, neoplasm, inflammatory bowel disease, and varices. Varices usually occur secondary to liver cirrhosis and are frequently located in the gastroesophageal region. Those occurring elsewhere are known as ectopic varices. The diagnosis and management of ectopic varices is challenging, and guidelines are not currently available. We report the case of recurrent large-volume hematochezia secondary to a cecal varix in a 60-year-old female with alcoholic liver cirrhosis. Initial investigation with CT angiography and endoscopy failed to identify the source of bleeding. A second CT angiogram identified a large varix in the cecum, and the patient was successfully managed with radiological embolization and transjugular intra-hepatic porto-systemic shunt (TIPSS)
Dipolar plasma source modeling: a first approach
International audienceThe scaling up of conventional plasmas presents limitations in terms of plasma density, limited to the critical density, and of uniformity, due to the difficulty of achieving constant amplitude standing wave patterns along linear microwave applicators in the meter range. An alternative solution lies in the concept of distribution from one- to two-dimensional networks of elementary plasma. Each elementary plasma source consists in a permanent magnet on which microwaves are applied via an independent coaxial line [1]. The plasma is produced by the electrons accelerated at ECR (Electron Cyclotron Resonance) and trapped in the dipolar magnetic field. Large-size uniform plasmas can be obtained by assembling as many such elementary plasma sources as necessary, without any physical or technical limitations [2]. Simulation of the plasma produced by a dipolar source requires a global, self consistent, modeling of its functioning. In order to obtain results to lead a first optimization of the dipolar source, magnetostatics, microwave propagation and fast electrons trajectories (Particles in Cell (PIC) and Monte-Carlo hybrid method [3]) have been performed with Comsol Multiphysics and MatLab
Discrete element simulation of wet granular materials: plastic compression
We use Discrete Element Method (DEM) simulations in three dimensions (3D) to study the quasistatic response of very loose assemblies of frictional spherical grains to an isotropic compression in the presence of a small amount of an interstitial liquid, which gives rise to capillary menisci and attractive forces. Previous results obtained in 2D [8] are generalized to systems that may be observed in the laboratory. We study the influence of the initial assembling process and of various micromechanical parameters on the plastic
compression curves, from very loose states assembled at low Pâ to maximally compressed ones in which capillary cohesion is negligible at large Pâ. We also show how the plastic response along those compression curves is influenced by rolling resistance in contacts
Analysing the merit of latent variables over traditional objective attributes for traveller mode choice using RPL model
In real life, the attributes that influence individual choice may be complex. The traditional objective attributes can be incorporated easily into choice models. However, there are also latent preference heterogeneities that are of ten overlooked by the traditional thinkers of transport planners. This paper deals with this issue firstly by testing the adequacy of objective attributes representing latent variables (LVs). It then quantifies the effect of LVs over objective attributes on traveller mode choice using the random parameter logit (RPL) model. Understanding these attributes is essential if transport agencies are to understand traveller behaviour when determining effective transport policies. This paper emphasises travellers\u27 LVs along with objective attributes during the mode choice process as a method by which the utility of the traveller can be maximised. Thus the issue of utility function is raised and evaluated using a discrete choice experiment, i.e. RPL model. An empirical study was carried out in the context of traveller behaviour in the Sydney Statistical Division (SSD). We consider six LVs and thirteen objective attributes to analyse the importance/merits of LVs over objective attributes in traveller mode choice. The results show that indicators of LVs and traveller choice attributes are found to be significant, while objective attributes show a very minimal (0% to 10% on average) capacity to reflect LVs in traveller choice processes. LVs are found to be more influential than objective attributes on the mode choice made by travellers and our results also show that hybrid RPL is superior to traditional RPL models that ignore the effect of LVs. Our results support the contention that latent factors are important in traveller mode choice in ways that are relevant to transportation planners and policy-makers. Although possibly not directly susceptible to policy intervention, a better understanding of these relationships is useful for decision makers and transportation planners when designing and developing sustainable transportation policies or projects for the city dwellers
Characteristic Changes in Decidual Gene Expression Signature in Spontaneous Term Parturition
Background: The decidua has been implicated in the "terminal pathway" of human term parturition, which is characterized by the activation of pro-inflammatory pathways in gestational tissues. However, the transcriptomic changes in the decidua leading to terminal pathway activation have not been systematically explored. This study aimed to compare the decidual expression of developmental signaling and inflammation-related genes before and after spontaneous term labor in order to reveal their involvement in this process. Materials and Methods: Chorioamniotic membranes were obtained from normal pregnant women who delivered at term with spontaneous labor (TIL, n=14) or without labor (TNL, n=15). Decidual cells were isolated from snap-frozen chorioamniotic membranes with laser microdissection. The expression of 46 genes involved in decidual development, sex steroid and prostaglandin signaling, as well as pro- and anti-inflammatory pathways was analyzed using high-throughput quantitative real-time polymerase chain reaction (qRT-PCR). Chorioamniotic membrane sections were immunostained and then semi-quantified for five proteins, and immunoassays for three chemokines were performed on maternal plasma samples. Results: The genes with the highest expression in the decidua at term gestation included insulin-like growth factor-binding protein 1 (IGFBP1), galectin-1 (LGALS1), and progestogen-associated endometrial protein (PAEP); the expression of estrogen receptor 1 (ESR1), homeobox A11 (HOXA11), interleukin 1beta (IL1B), IL8, progesterone receptor membrane component 2 (PGRMC2), and prostaglandin E synthase (PTGES) was higher in TIL than in TNL cases; the expression of chemokine C-C motif ligand 2 (CCL2), CCL5, LGALS1, LGALS3, and PAEP was lower in TIL than in TNL cases; immunostaining confirmed qRT-PCR data for IL-8, CCL2, galectin-1, galectin-3, and PAEP; and no correlations between the decidual gene expression and the maternal plasma protein concentrations of CCL2, CCL5, and IL-8 were found. Conclusion: Our data suggests that with the initiation of parturition, the decidual expression of anti-inflammatory mediators decreases, while the expression of pro-inflammatory mediators and steroid receptors increases. This shift may affect downstream signaling pathways that can lead to parturition
- âŠ