Alcohol use, negative consequences, and readiness to change in mandated and volunteer college student heavy drinkers before and after a brief alcohol intervention

The current study tested the efficacy of a brief intervention designed to reduce alcohol use among high-risk college students who have been mandated to treatment for an alcohol policy violation relative to a brief wait-list control group and volunteer high-risk sample. Thirty-nine mandated students and forty high-risk student volunteers were randomly assigned to receive either a brief alcohol intervention or were assigned to a brief wait-list control (WLC) group. Participants were assessed at baseline and at a 4-week post-test on measures of alcohol consumption, alcohol-related problems, and readiness to change. Of the participants who had completed follow-up (N = 39), mandated and voluntary high-risk students who received the brief intervention reported significant reductions in alcohol consumption (drinks per week) and relative to the WLC. Mandated students who received the intervention also reported greater decreases in drinking occasions per week relative to the WLC. High-risk students who received the intervention reported decreases in alcohol use and drinking related-consequences, which were not significant by referral status. Preliminary results provide some support for the efficacy of brief motivational enhancement interventions for reducing drinking in high-risk college students who are mandated to treatment

Protective Behavioral Strategies Underutilization Mediates Effect of a Brief Motivational Intervention among Socially Anxious Undergraduate Drinkers

Social anxiety (SA) is implicated in problematic undergraduate drinking. Brief motivational interventions (BMIs) reduce problematic undergraduate drinking. However, not all students benefit. Identification of vulnerable subgroups is an important next step. The current study examined the role of SA and protective behavioral strategies (PBS) on BMI outcomes. We reanalyzed a subset of data (53.3%; N = 120; 62.5% male) from a randomized trial in which heavy drinking undergraduates were randomized to a BMI or control. SA, past-month typical drinks, peak drinks, weekly quantity, alcohol problems, and PBS were assessed at baseline and 6-weeks. Main effects and interaction among the intervention condition (BMI vs. control) and SA group (low vs. high) were tested on alcohol outcomes and PBS. High SA undergraduates reported greater baseline drinking, more alcohol problems, and lower PBS. Post-BMI, high SA drinkers continued to report greater peak drinks, typical drinks, alcohol problems, and lower PBS use, controlling for baseline use. Among the BMI condition, parallel multiple mediation analyses revealed the PBS subscale Manner of Drinking uniquely mediated the relationship between SA and heavier post-BMI drinking. The PBS Manner of Drinking and Serious Harm Reduction subscales jointly mediated the relationship between SA and greater post-BMI alcohol problems. BMIs may need to be refined to improve outcomes for socially anxious drinkers. Increasing PBS utilization post-BMI may help improve BMI efficacy in this vulnerable group. Clinical implications are discussed

The Role of Underutilization of Protective Behavioral Strategies in the Relation of Social Anxiety with Risky Drinking

Social anxiety is prominent among undergraduates and increases the risk of experiencing alcohol problems. In fact, social anxiety more than quadruples the risk of developing an alcohol use disorder, yet it is inconsistently related to heavier drinking. Inconsistent findings may be due to lack of attention on protective behavioral strategies (PBS) among socially anxious drinkers. PBS are cognitive-behavioral strategies to reduce drinking and alcohol-related harm. Due to the nature of social anxiety, affected individuals may be especially vulnerable to PBS underutilization, leading to heavier and more problematic drinking. The current study examined the mediating role of PBS in the relationships of social anxiety with past-month drinking and alcohol problems using cross-sectional data among current (past-month) heavy undergraduate drinkers (N = 431). Social anxiety was significantly positively related to past-month alcohol problems and peak drinking. Social anxiety was significantly negatively related to typical drinking, drinking frequency, and PBSS Manner of Drinking. Social anxiety was indirectly (via PBSS Manner of Drinking) related to greater past-month peak drinks and more drinking problems. Findings suggest that socially anxious persons may be vulnerable to heavier and more problematic drinking due to PBS underutilization. Treatment implications are discussed

Respiratory insufficiency related to copd accelerates systemic inflammation, under-nutrition, and angiogenesis in esophageal malignancies

A number of esophageal cancer patients suffer from respiratory insufficiency due to the coexistence of chronic obstructive pulmonary disease (COPD). Aim: To test the hypothesis that COPD-related systemic hypoxemia may result in accelerated inflammation, malnutrition, and angiogenesis in esophageal cancer patients. Methods: Serum levels of C-reactive protein (CRP), albumin, transferrin, interleukin-1, interleukin-6, interleukin-8, TNF- a, platelet-derived growth factor (PDGF-BB), and midkine and patient BMI and weight-loss rate were determined and compared with blood oxygenation status (pO2, SaO2) in 35 esophageal cancer patients and 42 controls. Results: The incidence of cachexia tended to be higher in patients with systemic hypoxemia (67% vs 40%, p = 0.169). Mean SaO2 level was also significantly decreased in cachectic patients (90.3 vs 93.3%, p = 0.026) and pO2 exhibited a similar trend (58.0 vs 63.4 mmHg, p = 0.120). Transferrin (234 vs 316 mg/dl, p = 0.005) and albumin (31.9 vs 37.1 mg/dl, p = 0.002) concentrations were reduced and CRP was elevated (129.9 vs 54.7 mg/l, p = 0.004) in hypoxemic patients and correlated with pO2 (r = 0.47, p = 0.016; r = 0.48, p = 0.012; r = –0.37, p = 0.064) and SaO2 (r = 0.52, p = 0.006; r = 0.53, p = 0.006; r = –0.40, p = 0.042). Interleukin-6 (9.97 vs 2.21 pg/ml, p = 0.005) and midkine (2101 vs 944 pg/ml, p < 0.001) were elevated and PDGF-BB was decreased (12.2 vs 17.3 pg x 10-6/PLT, p = 0.014) in hypoxemic compared with normoxemic patients. Interleukin-6 and midkine negatively correlated with pO2 (r = –0.44, p = 0.016; r = –0.42, p = 0.011) and SaO2 (r = –0.54, p = 0.003; r = –0.57, p < 0.0001) and PDGF-BB correlated positively (r = 0.53, p = 0.003; r = 0.44, p = 0.020). Interleukin-8 level was affected by pO2 (r = -0.55, p = 0.015) and SaO2 (r = –0.55, p = 0.018) only in hypoxemic patients. Conclusions: COPD-related systemic hypoxemia negatively affects the status of esophageal cancer patients by accelerating inflammation, under-nutrition, and angiogenesis.Многие больные раком пищевода страдают от респираторной недостаточности из-за развития хронического обструктивного легочного заболевания (COPD). Цель: Проверить гипотезу о возможной связи системной гипоксемии, ассоциированной с COPD, с усилением воспалительных процессов, истощением и ангиогенезом у больных раком пищевода. Методы: у 35 больных раком пищевода и 42 здоровых доноров определяли уровень CRP, альбумина, трансферина, интерлейкина-1, интерлейкина-6, интерлейкина-8, TNF-α, PDGF-BB и мидкина в сыворотке крови, показатели BMI и потери веса больных, а также показатели уровня оксигенации крови (pO2 , SaO2 ). Результаты: частота возникновения кахексии была выше у больных с системной гипоксемией (67 против 40%, p = 0,169). Средний уровень SaO2 был также значительно снижен у больных с кахексией (90,3 против 93,3%, p = 0,026), с той же тенденцией и для уровня pO2 (58,0 против 63,4 mmHg, p = 0,120). Концентрации трансферина (234 против 316 мг/дл, p = 0,005) и альбумина (31,9 против 37,1 мг/дл, p = 0,002) были снижены, CRP повышен (129,9 против 54,7 мг/л, p = 0,004) у гипоксемических пациентов, что кореллировало с показателями pO2 (r = 0,47, p = 0,016; r = 0,48, p = 0,012; r = –0,37, p = 0,064) и SaO2 (r = 0,52, p = 0,006; r = 0,53, p = 0,006; r = –0,40, p = 0,042). Уровень интерлейкина-6 (9,97 против 2,21 pg/ml, p = 0,005) и мидкина (2101 против 944 pg/ml, p < 0,001) был также повышен, а уровень PDGF-BB понижен (12,2 против 17,3 pg × 10-6/PLT, p = 0,014) у гипоксемических больных по сравнению с показателями при нормоксемии. Уровни интерлейкина-6 и мидкина негативно кореллировали с показателями pO2 (r = –0,44, p = 0,016; r = –0,42, p = 0,011) и SaO2 (r = –0,54, p = 0,003; r = –0,57, p < 0,0001) и позитивно — с PDGF-BB (r = 0,53, p = 0,003; r = 0,44, p = 0,020). На уровень интерлейкина-8 влияли pO2 (r = –0,55, p = 0,015) и SaO2 (r = –0,55, p = 0,018) только у больных с гипоксемией. Выводы: ассоциированная с COPD системная гипоксемия негативно влияет на состояние больных раком пищевода за счет ускорения воспалительных процессов, истощения и ангиогенез

Fine structure of alpha decay in odd nuclei

Using an alpha decay level scheme, an explanation for the fine structure in odd nuclei is evidenced by taking into account the radial and rotational couplings between the unpaired nucleon and the core of the decaying system. It is stated that the experimental behavior of the alpha decay fine structure phenomenon is directed by the dynamical characteristics of the system.Comment: 8 pages, 3 figures, REVTex, submitted to Physical Review

Alcohol-induced risky sexual behavior among socially anxious drinkers

Heavy college drinking is associated with risky sexual behavior. It is therefore important to identify groups that are especially vulnerable to alcohol-influenced sexual risk (e.g., unplanned/unexpected sex). Undergraduates with elevated social anxiety represent one such vulnerable group given that social anxiety is associated with fear of intimacy and heavier drinking in intimate situations and situations with expected negative affect. Drinking to cope with negative affect induced by fear of intimacy might render socially anxious undergraduates vulnerable to risky sexual behavior, yet no known studies have examined this relationship. The current study tested whether social anxiety was related to alcohol-related sexual behaviors among current (past-month) drinking undergraduates (88.1% female; 77.6% non-Hispanic Caucasian) with higher (i.e., clinically elevated) social anxiety (HSA; n = 40) or lower (more normative) social anxiety (LSA; n = 94). Coping motives were examined as a moderator of the social anxiety-risky sexual behavior relationship. Gender was a covariate. HSA students reported more frequent alcohol-influenced sexual risk including regretted sexual situations, unprotected sex, sex with unwanted partners, unwanted sex, pressured/forced to have sex, and pressured someone to have sex. Coping motives significantly interacted with social anxiety group in the prediction of risky sexual behaviors except regretted sexual situations, such that HSA students with greater coping motives experienced more frequent sexual risk when drinking. Findings indicate that HSA students may be particularly vulnerable to risky sexual behaviors and suggest that coping motivated drinking may be an important target for therapeutic interventions geared toward reducing risky sexual behaviors among this high-risk population

Do Positive Alcohol Expectancies Have a Critical Developmental Period in Pre-Adolescents?

Objective: Positive outcome expectancies have been shown to predict initiation of alcohol use in children and to mediate and moderate the relationship between dispositional variables and drinking behavior. Negative outcome expectancies for alcohol appear to weaken as children progress to middle adolescence, but positive expectancies tend to increase during this time. Positive alcohol expectancies have been found to increase in children in third and fourth grades, indicating what some investigators have termed a possible critical period for the development of positive expectancies. Method: In the present study, we assessed alcohol expectancies at baseline, 6, 12, and 18 months in 277 secondthrough sixth-grade students. Children completed the Alcohol Expectancy Questionnaire–Adolescent. Univariate analyses of covariance were conducted. Results: There were signifi cant main effects for grade on positive alcohol-expectancy change for Global Positive Transformations at 12 and 18 months, Social Behavior Enhancement or Impediment at 6 and 12 months, and Relaxation/Tension Reduction at 6 and 18 months, whereby a consistent pattern emerged in that lower grades did not differ from each other, but they differed signifi cantly from the higher grades. Conclusions: Data support a critical developmental period for positive alcohol expectancies, with the greatest change observed between third and fourth grade and between fourth and fi fth grade, and only in those expectancies clearly describing positive outcomes (e.g., Relaxation/ Tension Reduction) via positive or negative reinforcement versus those with either combined or ambiguous outcomes (e.g., Social Behavior Enhancement or Impediment). (J. Stud. Alcohol Drugs, 75, 000–000, 2014

Context-Specific Drinking and Social Anxiety: The Roles of Anticipatory Anxiety and Post-Event Processing

Individuals with clinically elevated social anxiety are especially vulnerable to alcohol-related problems, despite not drinking more than those with less anxiety. It is therefore important to identify contexts in which socially anxious persons drink more to inform intervention efforts. This study tested whether social anxiety was related to greater drinking before, during, or after a social event and whether such drinking was related to the psychosocial factors anticipatory anxiety or post-event processing (PEP; review of the social event). Among past-month drinkers, those with clinically elevated or higher social anxiety (HSA; n = 212) reported more anticipatory anxiety, more pre-event drinking to manage anxiety, and PEP than those with normative or lower social anxiety (LSA; n = 365). There was a significant indirect effect of social anxiety on pre-drinking via anticipatory anxiety. Social anxiety was related to more drinking during the event indirectly via the serial effects of anticipatory anxiety and pre-drinking. Unexpectedly, PEP did not mediate or moderate the relation between social anxiety and post-event drinking. In sum, anticipatory anxiety was related to more drinking before, during, and after a social event and HSA drinkers were especially vulnerable to drinking more to manage this anxiety, which increased drinking before and during the event. This effect was specific to anticipatory anxiety and not evident for another social anxiety-specific risk factor, PEP. Thus, anticipatory anxiety may be an important therapeutic target for drinkers generally and may be especially important among HSA drinkers

Hydrodesulfurization of light gas oil - kinetic determination in a batch reactor [Hidrodesulfurizacija lakog gasnog ulja - ispitivanje kinetike HDS u šaržnom reaktoru]

The performed investigations were directed toward the analysis of the performance and activity of the fresh and regenerated Cyanamid HDS 20C catalyst in a laboratory batch reactor (2 dm3) for the HDS of the diesel fraction (light gas oil, LGO). Testing of the regenerated catalyst was performed with light gas oil (LGO) of different characteristics. The determined values of the reaction rate constant were compared to some published data in the literature for the HDS of specific sulfur compounds as well as the values of the activation energy. The rates of deactivation of the fresh and regenerated catalyst actually existed compared to some other results recently published in the literature. However, such an observed differences were not sufficient to derive a relation which could be used for the determination of the rate of catalyst deactivation