70 research outputs found
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
Target metabolite and gene transcription profiling during the development of superficial scald in apple (Malus x domestica Borkh)
The Phytoene synthase gene family of apple (Malus x domestica) and its role in controlling fruit carotenoid content
La educación ambiental en la Argentina: actores, conflictos y políticas públicas
Es preciso comenzar por deconstruir críticamente los cimientos que sostienen los sistemas educativos que promueven estilos de vida insustentables, desafiando sus dispositivos de dominación, así como los discursos y prácticas que los generan. Solo de este modo estaremos construyendo una educación ambiental constitutiva del cambio social; una educación ambiental que empodere a las comunidades organizadas para impedir mediante la insurgencia política, la resistencia cultural, la resiliencia social y el pensamiento decolonial que sus estrategias sean metabolizadas por el sistema. Una educación ambiental que sitúe la reflexión y la práctica pedagógica en problemáticas concretas, que permitan trascender las usuales medidas cosméticas y los granitos de arena que operan como lavados de conciencia que obstruyen la construcción de ciudadanía. Una educación ambiental generadora de sentidos emancipadores que hagan posible diseñar otros mapas simbólicos para guiar nuestras vidas
How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina
Azobenzene photoswitches confer light sensitivity onto retinal ganglion cells (RGCs) in blind mice, making these compounds promising candidates as vision-restoring drugs in humans with degenerative blindness. Remarkably, photosensitization manifests only in animals with photoreceptor degeneration and is absent from those with intact rods and cones. Here we show that P2X receptors mediate the entry of photoswitches into RGCs, where they associate with voltage-gated ion channels, enabling light to control action-potential firing. All charged photoswitch compounds require permeation through P2X receptors, whose gene expression is upregulated in the blind retina. Photoswitches and membrane-impermeant fluorescent dyes likewise penetrate through P2X receptors to label a subset of RGCs in the degenerated retina. Electrophysiological recordings and mapping of fluorescently labeled RGC dendritic projections together indicate that photosensitization is highly selective for OFFRGCs. Hence, P2X receptors are a natural conduit allowing cell-type-selective and degeneration-specific delivery of photoswitches to restore visual function in blinding disease
Intrathoracic Airway Closure Impacts CO 2 Signal and Delivered Ventilation during Cardiopulmonary Resuscitation
International audienc
Duration of Diaphragm Inactivity After Endotracheal Intubation of Critically Ill Patients - The Divip Study
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