Routine MRI findings of the asymptomatic foot in diabetic patients with unilateral Charcot foot

<p>Abstract</p> <p>Background</p> <p>Imaging studies of bones in patients with sensory deficits are scarce.</p> <p>Aim</p> <p>To investigate bone MR images of the lower limb in diabetic patients with severe sensory polyneuropathy, and in control subjects without sensory deficits.</p> <p>Methods</p> <p>Routine T1 weighted and T2-fat-suppressed-STIR-sequences without contrast media were performed of the asymptomatic foot in 10 diabetic patients with polyneuropathy and unilateral inactive Charcot foot, and in 10 matched and 10 younger, non-obese unmatched control subjects. Simultaneously, a Gadolinium containing phantom was also assessed for reference. T1 weighted signal intensity (SI) was recorded at representative regions of interest at the peritendineal soft tissue, the tibia, the calcaneus, and at the phantom. Any abnormal skeletal morphology was also recorded.</p> <p>Results</p> <p>Mean SI at the soft tissue, the calcaneus, and the tibia, respectively, was 105%, 105% and 84% of that at the phantom in the matched and unmatched control subjects, compared to 102% (soft tissue), 112% (calcaneus) and 64% (tibia) in the patients; differences of tibia vs. calcaneus or soft tissue were highly significant (p < 0.005). SI at the tibia was lower in the patients than in control subjects (p < 0.05). Occult traumatic skeletal lesions were found in 8 of the 10 asymptomatic diabetic feet (none in the control feet).</p> <p>Conclusion</p> <p>MR imaging did not reveal grossly abnormal bone marrow signalling in the limbs with severe sensory polyneuropathy, but occult sequelae of previous traumatic injuries.</p

The Founder’s Lecture 2009: advances in imaging of osteoporosis and osteoarthritis

The objective of this review article is to provide an update on new developments in imaging of osteoporosis and osteoarthritis over the past three decades. A literature review is presented that summarizes the highlights in the development of bone mineral density measurements, bone structure imaging, and vertebral fracture assessment in osteoporosis as well as MR-based semiquantitative assessment of osteoarthritis and quantitative cartilage matrix imaging. This review focuses on techniques that have impacted patient management and therapeutic decision making or that potentially will affect patient care in the near future. Results of pertinent studies are presented and used for illustration. In summary, novel developments have significantly impacted imaging of osteoporosis and osteoarthritis over the past three decades

Functional diffusion-weighted magnetic resonance spectroscopy of the human primary visual cortex at 7 T

Neuro Imaging Researc

Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology

Neuro Imaging Researc

Diffusion-weighted chemical shift imaging of human brain metabolites at 7T

Neuro Imaging Researc

Investigating Axonal Damage in Multiple Sclerosis by Diffusion Tensor Spectroscopy

Neuro Imaging Researc

Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T

Neuro Imaging Researc

Cortical Bone Water: In Vivo Quantification with Ultrashort Echo-Time MR Imaging1

Results of this work demonstrate that bone water and, by inference, cortical porosity (because the majority of bone water is in the spaces of the haversian and lacunocanalicular systems), can be measured noninvasively in patients by using quantitative ultrashort echo-time MR imaging

Multi-objective Aggregate Production Planning Model Considering Overtime and Outsourcing Options Under Fuzzy Seasonal Demand

This paper investigates a novel fuzzy multi-objective multi-period Aggregate Production Planning (APP) problem under seasonal demand. As two of the main real-world assumptions, the options of workforce overtime and outsourcing are studied in the proposed Mixed-Integer Linear Programming (MILP) model. The main goals are to minimize the total cost including in-house production, outsourcing, workforce, holding, shortage and employment/ unemployment costs, and maximize the customers' satisfaction level. To deal with demand uncertainty, triangular fuzzy numbers are considered for demand parameters. Then the proposed model is validated by solving an illustrative example using a Weighted Goal Programming (WGP) method and CPLEX solver. Finally, it is demonstrated that uncertain conditions and considering real-world assumptions can yield different results in developing a practical aggregate production plan. Moreover, a sensitivity analysis is then performed to provide qualitative managerial insights and decision aids