106 research outputs found
Polimorfismo do alelo HLA-B27 no desenvolvimento das espondilartropatias
A associação da molécula HLA-B27 com a espondilite anquilosante (AS) e outras espondilartropatias (SpA), permanece como uma das mais fortes verificada entre moléculas HLA e doenças humanas. Desde que foi descrita, em 1973, tem sido alvo de intensa investigação na tentativa de compreender o mecanismo patogénico que lhe estå subjacente. Este artigo tem como objectivo fazer uma revisão dos conhecimentos actuais relativos à estrutura e polimorfismo da molécula HLA-B27, bem como descrever os modelos propostos para explicar o seu papel no desenvolvimento das espondilartropatias.The association of HLA-B27 with ankylosing spondylitis (AS), and other spondyloarthropathies (SpA), remains as one of the strongest between HLA molecules and human disease. Since it was reported, in 1973, it has been extensively studied in order to understand the underlying pathogenic mechanism. The objective of this article is to review the current knowledge on the structure and polymorphism of HLA-B27 molecule, as well as describe the main pathogenic hypotheses trying to explain its association with AS.info:eu-repo/semantics/publishedVersio
Prevalence of H63D, S65C, and C282Y hereditary hemochromatosis gene variants in Madeira Island (Portugal)
HLA Class I and II profiles in SĂŁo Miguel Island (Azores): genetic diversity and linkage disequilibrium
Copper, zinc and manganese determination in saline samples employing faas after separation and preconcentration on Amberlite XAD-7 and Dowex 1x-8 loaded with Alizarin Red S
Linkage disequilibrium and diversity for three genomic regions in Azoreans and mainland Portuguese
Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group
Previous studies indicate that the frequency distributions of HLA alleles and haplotypes vary from one ethnic group to another or between the members of the same ethnic group living in different geographic areas. It is necessary and meaningful to study the high-resolution allelic and haplotypic distributions of HLA loci in different groups.High-resolution HLA typing for the Uyghur ethnic minority group using polymerase chain reaction-sequence-based-typing method was first reported. HLA-A, -B and -DRB1 allelic distributions were determined in 104 unrelated healthy Uyghur individuals and haplotypic frequencies and linkage disequilibrium parameters for HLA loci were estimated using the maximum-likelihood method. A total of 35 HLA-A, 51 HLA-B and 33 HLA-DRB1 alleles were identified at the four-digit level in the population. High frequency alleles were HLA-A*1101 (13.46%), A*0201 (12.50%), A*0301 (10.10%); HLA-B*5101(8.17%), B*3501(6.73%), B*5001 (6.25%); HLA-DRB1*0701 (16.35%), DRB1*1501 (8.65%) and DRB1*0301 (7.69%). The two-locus haplotypes at the highest frequency were HLA-A*3001-B*1302 (2.88%), A*2402-B*5101 (2.86%); HLA-B*5001-DRB1*0701 (4.14%) and B*0702-DRB1*1501 (3.37%). The three-locus haplotype at the highest frequency was HLA-A*3001-B*1302-DRB1*0701(2.40%). Significantly high linkage disequilibrium was observed in six two-locus haplotypes, with their corresponding relative linkage disequilibrium parameters equal to 1. Neighbor-joining phylogenetic tree between the Uyghur group and other previously reported populations was constructed on the basis of standard genetic distances among the populations calculated using the four-digit sequence-level allelic frequencies at HLA-A, HLA-B and HLA-DRB1 loci. The phylogenetic analyses reveal that the Uyghur group belongs to the northwestern Chinese populations and is most closely related to the Xibe group, and then to Kirgiz, Hui, Mongolian and Northern Han.The present findings could be useful to elucidate the genetic background of the population and to provide valuable data for HLA matching in clinical bone marrow transplantation, HLA-linked disease-association studies, population genetics, human identification and paternity tests in forensic sciences
Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella
11 p.-6 fig.Plastic degradation by biological systems with re-utilization of the by-products can be the future solution
to the global threat of plastic waste accumulation. We report that the saliva of Galleria mellonella larvae
(wax worms) is capable of oxidizing and depolymerizing polyethylene (PE), one of the most produced and
sturdy polyolefin-derived plastics. This effect is achieved after a few hoursâ exposure at room temperature
and physiological conditions (neutral pH). The wax worm saliva can indeed overcome the bottleneck step in
PE biodegradation, that is the initial oxidation step. Within the saliva, we identified two enzymes that can
reproduce the same effect. This is the first report of enzymes with this capability, opening up the way to new
ground-breaking solutions for plastic waste management through bio-recycling/up-cycling.Roechling Stiftung to FB
Consejo Superior de Investigaciones CientĂficas (CSIC) to FB
NATO Science for Peace and Security Programme (Grant SPS G5536) to TT
Junta de Castilla y LeĂłn, ConsejerĂa de EducaciĂłn y Cultura y Fondo Social Europeo (Grant BU263P18) to
TT
Ministerio de Ciencia e InnovaciĂłn (Grant PID2019-111215RB-100) to TT
The Generalitat de Catalunya (2017 SGR 1192) to MS
Ministerio de Ciencia e InnovaciĂłn (Grant BFU2017-89143-P) to EA-PN
BOTĂNICA E FISIOLOGIA/ BOTANY AND PHYSIOLOGY ANTIOXIDANT ACTIVITY AND PHYSICOCHEMICAL PARAMETERS IN âCUERNAVAQUEĂAâ MEXICAN PLUM (Spondias purpurea L.) AT DIFFERENT RIPENING STAGES
- âŠ