Chromohysteroscopy after failed intracytoplasmic sperm injection

Background: ICSI is the injection of a single sperm directly into the cytoplasm of the oocyte (ICSI). The failure to achieve pregnancy after ICSI has been studied over many years to reach the possible and preventable causes to avoid another failure. The aim of this study was to assess the value of using Chromohysteroscopy as a part of the work up of cases with one or more failed ICSI. The Ultimate goal is to detect the possible endometrial abnormalities and /or endometritis.Methods: Prospective cohort study was carried out with total of 50 infertile women recruited from infertility clinic in Elshatby Maternity University Hospital, Alexandria University, Egypt. Cases were allocated in 2 groups with 25 cases in each group. The first group included cases that had a failed trial of ICSI. The second group included control cases who were seeking for fertility treatment with no previous history of ICSI or any uterine surgery or anatomical abnormalities. In the postmenstrual period, Chromohysteroscopy was done by the same surgeon and documentation of all findings in the cavity and presence of endometritis.Results: There was a significant increase in the incidence of endometritis among the study group 68% in comparison to 16% in the control group.Conclusions: In this study endometrial dying with methylene blue at hysteroscopy improve the detection of chronic endometritis

WASP-39b: exo-Saturn with patchy cloud composition, moderate metallicity, and underdepleted S/O

WASP-39b is one of the first extrasolar giant gas planets that has been observed within the JWST ERS program. Fundamental properties that may enable the link to exoplanet formation differ amongst retrieval methods, for example metallicity and mineral ratios. In this work, the formation of clouds in the atmosphere of WASP-39b is explored to investigate how inhomogeneous cloud properties (particle sizes, material composition, opacity) may be for this intermediately warm gaseous exoplanet. WASP-39b's atmosphere has a comparable day-night temperature median with sufficiently low temperatures that clouds may form globally. The presence of clouds on WASP-39b can explain observations without resorting to a high (> 100x solar) metallicity atmosphere for a reduced vertical mixing efficiency. The assessment of mineral ratios shows an under-depletion of S/O due to condensation compared to C/O, Mg/O, Si/O, Fe/O ratios. Vertical patchiness due to heterogeneous cloud composition challenges simple cloud models. An equal mixture of silicates and metal oxides is expected to characterise the cloud top. Further, optical properties of Fe and Mg silicates in the mid-infrared differ significantly which will impact the interpretation of JWST observations. We conclude that WASP-39b's atmosphere contains clouds and the underdepletion of S/O by atmospheric condensation processes suggest the use of sulphur gas species as a possible link to primordial element abundances. Over-simplified cloud models do not capture the complex nature of mixed-condensate clouds in exoplanet atmospheres. The clouds in the observable upper atmosphere of WASP-39b are a mixture of different silicates and metal oxides. The use of constant particles sizes and/or one-material cloud particles alone to interpret spectra may not be sufficient to capture the full complexity available through JWST observations.Comment: 21 pages, 18 figures, submitted to A&A on 22. November 2022, in review since 8. December 202

Drug utilization pattern in OPD of government dental college and hospital, Aurangabad

Background: To study drug prescription pattern in dental OPD of Government Dental College and Hospital.Methods: 100 prescriptions were screened & analyzed as per the study parameters from OPD of Government Dental College & Hospital, Aurangabad. Groups of drugs commonly prescribed, like antibiotic, analgesics & others prescription were recorded.Results: Most common groups of drugs prescribed by dental surgeons were NSAIDs, antimicrobials, antiseptics and multivitamins. NSAIDs- 86%; Antimicrobials- 85%; Antiseptics- 8.6%; Multivitamins- 12.3%. The average number of drugs prescribed per patient was 3 and the average number of antimicrobial prescribed per patient was 1.Conclusions: For rational prescribing of drugs there is a need of mass-awareness amongst dental surgeons about the good prescribing by following 6 steps of WHO program on rational use of drugs

Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids

OBJECTIVE: Gluteo-femoral, in contrast to abdominal, fat accumulation appears protective against diabetes and cardiovascular disease. Our objective was to test the hypothesis that this reflects differences in the ability of the two depots to sequester fatty acids, with gluteo-femoral fat acting as a longer-term "sink." RESEARCH DESIGN AND METHODS: A total of 12 healthy volunteers were studied after an overnight fast and after ingestion of a mixed meal. Blood samples were taken from veins draining subcutaneous femoral and abdominal fat and compared with arterialized blood samples. Stable isotope-labeled fatty acids were used to trace specific lipid fractions. In 36 subjects, adipose tissue blood flow in the two depots was monitored with (133)Xe. RESULTS: Blood flow increased in response to the meal in both depots, and these responses were correlated (r(s) = 0.44, P < 0.01). Nonesterified fatty acid (NEFA) release was suppressed after the meal in both depots; it was lower in femoral fat than in abdominal fat (P < 0.01). Plasma triacylglycerol (TG) extraction by femoral fat was also lower than that by abdominal fat (P = 0.05). Isotopic tracers showed that the difference was in chylomicron-TG extraction. VLDL-TG extraction and direct NEFA uptake were similar in the two depots. CONCLUSIONS: Femoral fat shows lower metabolic fluxes than subcutaneous abdominal fat, but differs in its relative preference for extracting fatty acids directly from the plasma NEFA and VLDL-TG pools compared with chylomicron-TG

Desperately seeking fixedness: practitioners accounts of 'becoming doctoral researchers

We draw upon the concept of liminality to explore the experiences of practitioners enrolled on a UK Doctor of Business Administration (DBA) programme. We analyse twenty practitioners’ reflective journals to detail how the DBA liminal space was negotiated. More specifically, we describe how practitioners deal with their struggles of identity incoherence or ‘monsters of doubt’ which are amplified in the DBA context owing to the complex nature of the separation phase of liminality. We identify three broad methods deployed in this endeavour: ‘scaffolding’; ‘putting the past to work’ and ‘bracketing’- which evidence practitioners ‘desperately seeking fixedness’. We make three contributions – first, we provide empirical insights into the experiences of the increasingly significant, but still under researched, DBA student. Second, we develop our understandings of monsters of doubt through illustrating how these are negotiated for learning to progress. Finally, we contribute to wider discussions of ‘becoming’ to demonstrate the simultaneous and paradoxical importance of movement and fixedness in order to learn and become