Topological Symmetries

We introduce the notion of a topological symmetry as a quantum mechanical symmetry involving a certain topological invariant. We obtain the underlying algebraic structure of the Z_2-graded uniform topological symmetries of type (1,1) and (2,1). This leads to a novel derivation of the algebras of supersymmetry and $p=2$ parasupersummetry.Comment: Plain LaTeX Ref: Mod. Phys. Lett. A 15, 175-184 (2000

A review of CAD/CAM use in dentistry (part II): Comparison of intraoral digital scanners used in restorative dentistry

Introduction: Intraoral imaging technology has become one of the most exciting new fields in dentistry. Three-dimensional scanning of the oral cavity is used in many dental procedures such as restorative dentistry and orthodontics. To date, a number of intraoral scanners have been developed for restorative dentistry throughout the world, and many researchers and manufacturers seek the design and development of new digital devices. Only some of these devices are currently available on the market and some others are being clinically tested. All existing intraoral scanners try to overcome the drawbacks of traditional impression processes. The aim of the present article is to provide an extensive evaluation of intraoral scanners in restorative dentistry, with special attention to their assessment principles, characteristics and performance. Review report: This review article was prepared by scientific searching in electronic sources of Pubmed and ISI Web of Science in connection with articles published in English until 2014, and with these key words: intraoral scanners and digital impression. Conclusion: Over the years there have been major advances in digital scanning systems, and a variety of digital systems have been introduced that enable the dentist to select different intraoral reconstruction methods in the extraoral environment. The ultimate goal of dentists is to provide accurate and efficient dental restorations for the patient, while maintaining patient comfort during the impression process. High-resolution dental optical scanners will enable the operator to provide high-quality restorations. With digital impression techniques, the number of operators and material variables will decrease, making restoration fabrication processes more predictable and easier

On the Statistical Origin of Topological Symmetries

We investigate a quantum system possessing a parasupersymmetry of order 2, an orthosupersymmetry of order $p$, a fractional supersymmetry of order $p+1$, and topological symmetries of type $(1,p)$ and $(1,1,...,1)$. We obtain the corresponding symmetry generators, explore their relationship, and show that they may be expressed in terms of the creation and annihilation operators for an ordinary boson and orthofermions of order $p$. We give a realization of parafermions of order~2 using orthofermions of arbitrary order $p$, discuss a $p=2$ parasupersymmetry between $p=2$ parafermions and parabosons of arbitrary order, and show that every orthosupersymmetric system possesses topological symmetries. We also reveal a correspondence between the orthosupersymmetry of order $p$ and the fractional supersymmetry of order $p+1$.Comment: 12 page

Virtual patient design : exploring what works and why : a grounded theory study

Objectives: Virtual patients (VPs) are online representations of clinical cases used in medical education. Widely adopted, they are well placed to teach clinical reasoning skills. International technology standards mean VPs can be created, shared and repurposed between institutions. A systematic review has highlighted the lack of evidence to support which of the numerous VP designs may be effective, and why. We set out to research the influence of VP design on medical undergraduates. Methods: This is a grounded theory study into the influence of VP design on undergraduate medical students. Following a review of the literature and publicly available VP cases, we identified important design properties. We integrated them into two substantial VPs produced for this research. Using purposeful iterative sampling, 46 medical undergraduates were recruited to participate in six focus groups. Participants completed both VPs, an evaluation and a 1-hour focus group discussion. These were digitally recorded, transcribed and analysed using grounded theory, supported by computer-assisted analysis. Following open, axial and selective coding, we produced a theoretical model describing how students learn from VPs. Results: We identified a central core phenomenon designated ‘learning from the VP’. This had four categories: VP Construction; External Preconditions; Student–VP Interaction, and Consequences. From these, we constructed a three-layer model describing the interactions of students with VPs. The inner layer consists of the student's cognitive and behavioural preconditions prior to sitting a case. The middle layer considers the VP as an ‘encoded object’, an e-learning artefact and as a ‘constructed activity’, with associated pedagogic and organisational elements. The outer layer describes cognitive and behavioural change. Conclusions: This is the first grounded theory study to explore VP design. This original research has produced a model which enhances understanding of how and why the delivery and design of VPs influence learning. The model may be of practical use to authors, institutions and researchers

The effect of age and clinical circumstances on the outcome of red blood cell transfusion in critically ill patients

Introduction: Whether red blood cell (RBC) transfusion is beneficial remains controversial. In both retrospective and prospective evaluations, transfusion has been associated with adverse, neutral, or protective effects. These varying results likely stem from a complex interplay between transfusion, patient characteristics, and clinical context. The objective was to test whether age, comorbidities, and clinical context modulate the effect of transfusion on survival. Methods: By using the multiparameter intelligent monitoring in intensive care II database (v. 2.6), a retrospective analysis of 9,809 critically ill patients, we evaluated the effect of RBC transfusion on 30-day and 1-year mortality. Propensity score modeling and logistic regression adjusted for known confounding and assessed the independent effect of transfusion on 30-day and 1-year mortality. Sensitivity analysis was performed by using 3,164 transfused and non-transfused pairs, matched according the previously validated propensity model for RBC transfusion. Results: RBC transfusion did not affect 30-day or 1-year mortality in the overall cohort. Patients younger than 55 years had increased odds of mortality (OR, 1.71; P < 0.01) with transfusion. Patients older than 75 years had lower odds of 30-day and 1-year mortality (OR, 0.70; P < 0.01) with transfusion. Transfusion was associated with worse outcome among patients undergoing cardiac surgery (OR, 2.1; P < 0.01). The propensity-matched population corroborated findings identified by regression adjustment. Conclusion: A complex relation exists between RBC transfusion and clinical outcome. Our results show that transfusion is associated with improved outcomes in some cohorts and worse outcome in others, depending on comorbidities and patient characteristics. As such, future investigations and clinical decisions evaluating the value of transfusion should account for variations in baseline characteristics and clinical context. Electronic supplementary material The online version of this article (doi:10.1186/s13054-014-0487-z) contains supplementary material, which is available to authorized users

N-fold Supersymmetry in Quantum Systems with Position-dependent Mass

We formulate the framework of N-fold supersymmetry in one-body quantum mechanical systems with position-dependent mass (PDM). We show that some of the significant properties in the constant-mass case such as the equivalence to weak quasi-solvability also hold in the PDM case. We develop a systematic algorithm for constructing an N-fold supersymmetric PDM system. We apply it to obtain type A N-fold supersymmetry in the case of PDM, which is characterized by the so-called type A monomial space. The complete classification and general form of effective potentials for type A N-fold supersymmetry in the PDM case are given.Comment: 18 pages, no figures; Refs. updated, typos correcte

αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome.

Alternative splicing (AS) is a robust generator of mammalian transcriptome complexity. Splice site specification is controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins. These interactions are frequently localized to the intronic U-rich polypyrimidine tracts (PPT) located 5' to the majority of splice acceptor junctions. αCPs (also referred to as polyC-binding proteins (PCBPs) and hnRNPEs) comprise a subset of KH-domain proteins with high affinity and specificity for C-rich polypyrimidine motifs. Here, we demonstrate that αCPs promote the splicing of a defined subset of cassette exons via binding to a C-rich subset of polypyrimidine tracts located 5' to the αCP-enhanced exonic segments. This enhancement of splice acceptor activity is linked to interactions of αCPs with the U2 snRNP complex and may be mediated by cooperative interactions with the canonical polypyrimidine tract binding protein, U2AF65. Analysis of αCP-targeted exons predicts a substantial impact on fundamental cell functions. These findings lead us to conclude that the αCPs play a direct and global role in modulating the splicing activity and inclusion of an array of cassette exons, thus driving a novel pathway of splice site regulation within the mammalian transcriptome

Low-temperature illumination and annealing of ultra-high quality quantum wells

The effects of low temperature illumination and annealing on fractional quantum Hall (FQH) characteristics of a GaAs/AlGaAs quantum well are investigated. Illumination alone, below 1 K, decreases the density of the 2DEG electrons by more than an order of magnitude and resets the sample to a repeatable initial state. Subsequent thermal annealing at a few Kelvin restores the original density and dramatically improves FQH characteristics. A reliable illumination and annealing recipe is developed that yields an energy gap of 600 mK for the 5/2 state