Massive photons and Dirac monopoles: electric condensate and magnetic confinement

We use the generalized Julia-Toulouse approach (GJTA) for condensation of topological currents (charges or defects) to argue that massive photons can coexist consistently with Dirac monopoles. The Proca theory is obtained here via GJTA as a low energy effective theory describing an electric condensate and the mass of the vector boson is responsible for generating a Meissner effect which confines the magnetic defects in monopole-antimonopole pairs connected by physical open magnetic vortices described by Dirac brane invariants, instead of Dirac strings.Comment: 6 pages, version accepted for publication in Physics Letters

Dynamics of kinks in the Ginzburg-Landau equation: Approach to a metastable shape and collapse of embedded pairs of kinks

We consider initial data for the real Ginzburg-Landau equation having two widely separated zeros. We require these initial conditions to be locally close to a stationary solution (the ``kink'' solution) except for a perturbation supported in a small interval between the two kinks. We show that such a perturbation vanishes on a time scale much shorter than the time scale for the motion of the kinks. The consequences of this bound, in the context of earlier studies of the dynamics of kinks in the Ginzburg-Landau equation, [ER], are as follows: we consider initial conditions $v_0$ whose restriction to a bounded interval $I$ have several zeros, not too regularly spaced, and other zeros of $v_0$ are very far from $I$. We show that all these zeros eventually disappear by colliding with each other. This relaxation process is very slow: it takes a time of order exponential of the length of $I$

Isocitrate lyore-2 from N. crassa

Isocitrate lyase-2 from N. crass

Vanishing DC holographic conductivity from a magnetic monopole condensate

We show how to obtain a vanishing DC conductivity in 3-dimensional strongly coupled QFT's using a massive 2-form field in the bulk that satisfies a special kind of boundary condition. The real and imaginary parts of the AC conductivity are evaluated in this holographic setup and we show that the DC conductivity identically vanishes even for an arbitrarily small (though nonzero) value of the 2-form mass in the bulk. We identify the bulk action of the massive 2-form with an effective theory describing a phase in which magnetic monopoles have condensed in the bulk. Our results indicate that a condensate of magnetic monopoles in a 4-dimensional bulk leads to a vanishing DC holographic conductivity in 3-dimensional strongly coupled QFT's.Comment: 24 pages, 2 figures, accepted for publication in JHE

Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell.

Next-generation sequencing offers an unprecedented opportunity to jointly analyze cellular and viral transcriptional activity without prerequisite knowledge of the nature of the transcripts. SupT1 cells were infected with a vesicular stomatitis virus G envelope protein (VSV-G)-pseudotyped HIV vector. At 24 h postinfection, both cellular and viral transcriptomes were analyzed by serial analysis of gene expression followed by high-throughput sequencing (SAGE-Seq). Read mapping resulted in 33 to 44 million tags aligning with the human transcriptome and 0.23 to 0.25 million tags aligning with the genome of the HIV-1 vector. Thus, at peak infection, 1 transcript in 143 is of viral origin (0.7%), including a small component of antisense viral transcription. Of the detected cellular transcripts, 826 (2.3%) were differentially expressed between mock- and HIV-infected samples. The approach also assessed whether HIV-1 infection modulates the expression of repetitive elements or endogenous retroviruses. We observed very active transcription of these elements, with 1 transcript in 237 being of such origin, corresponding on average to 123,123 reads in mock-infected samples (0.40%) and 129,149 reads in HIV-1-infected samples (0.45%) mapping to the genomic Repbase repository. This analysis highlights key details in the generation and interpretation of high-throughput data in the setting of HIV-1 cellular infection

Attention deficit hyperactivity disorder and future alcohol outcomes: Examining the roles of coping and enhancement drinking motives among young men.

Although there is evidence that Attention Deficit Hyperactivity Disorder (ADHD) symptoms are positively related to alcohol use and related problems among young adults, little research has examined the mechanisms that might explain this association. In response, this study examined the mediating effects of coping and enhancement drinking motives on the prospective associations between ADHD symptoms and alcohol outcomes. Participants (N = 4,536) were young men from the Cohort Study on Substance Use Risk Factors. Measures of ADHD symptoms and those of drinking motives, heavy episodic drinking (HED) and alcohol use disorder symptoms were used from the baseline and 15-month follow-up assessments. Findings indicated that the associations of ADHD-inattention symptoms with alcohol use disorder (AUD) symptoms and with HED were partially and completely mediated through drinking motives, respectively, whereas drinking motives did not mediate the ADHD-hyperactivity/impulsivity-symptoms-alcohol outcomes associations. Results indicated that coping and enhancement motives partially explained the ADHD-inattention symptoms-subsequent alcohol outcomes association. These findings suggest that interventions targeting enhancement and coping motives may help prevent problematic drinking among young men with elevated ADHD-inattention symptoms

The Microbe browser for comparative genomics

The Microbe browser is a web server providing comparative microbial genomics data. It offers comprehensive, integrated data from GenBank, RefSeq, UniProt, InterPro, Gene Ontology and the Orthologs Matrix Project (OMA) database, displayed along with gene predictions from five software packages. The Microbe browser is daily updated from the source databases and includes all completely sequenced bacterial and archaeal genomes. The data are displayed in an easy-to-use, interactive website based on Ensembl software. The Microbe browser is available at http://microbe.vital-it.ch/. Programmatic access is available through the OMA application programming interface (API) at http://microbe.vital-it.ch/api