Filling the gaps of development logs and bug issue data

It has been suggested that the data from bug repositories is not always in sync or complete compared to the logs detailing the actions of developers on source code. In this paper, we trace two sources of information relative to software bugs: the change logs of the actions of developers and the issues reported as bugs. The aim is to identify and quantify the discrepancies between the two sources in recording and storing the developer logs relative to bugs. Focussing on the databases produced by two mining software repository tools, CVSAnalY and Bicho, we use part of the SZZ algorithm to identify bugs and to compare how the"defects-fixing changes" are recorded in the two databases. We use a working example to show how to do so. The results indicate that there is a significant amount of information, not in sync when tracing bugs in the two databases. We, therefore, propose an automatic approach to re-align the two databases, so that the collected information is mirrored and in sync.Dr. Felipe Orteg

Estrogen Receptor (ER) Alpha Regulatory Mechanisms and Therapeutic Strategies in ER+ Breast Cancer

Breast cancer is among the most frequently diagnosed cancers in the U.S. and is one of the leading causes of cancer-related mortalities, second to lung cancer. Estrogen receptor alpha-positive (ER+) breast cancer accounts for 2/3 of diagnosed cases. Patients diagnosed with this subtype of breast cancer typically undergo endocrine therapy that aims to mitigate the growth-promoting effects of estrogen/ER. While therapies are effective, 1/3 of patients will experience recurrence. To begin addressing this drug-resistant patient population, we investigated potential drug targets involved in response to treatment. Coregulators have been implicated in the regulation of ER transcriptional activity and subsequently affecting the success of treatment with endocrine therapies. Using the mutant biotin ligase labeling system TurboID, we profiled the ER interactome in response to estrogen to identify novel regulators of ER activity. By identifying novel targets, we aim to identify new therapeutically targetable vulnerabilities. Upon cancer recurrence with endocrine therapies, patients are often switched to an alternative endocrine therapy combined with another targeted therapeutic such as a phosphatidylinositol 3,4,5-trisphosphate (PI3K) inhibitor. To further address the potential mechanisms of resistance to targeted therapies such as PI3K inhibitors, we have generated resistance models under various genetic mutations (PIK3CA and PTEN) in the setting of fulvestrant resistance to ascertain kinases that could potentiate tumor survival. Phosphoproteomic analysis of PTEN deficient tumors resistant to PI3K inhibition identified ATM as a top kinase for further validation as to its role in the development of PI3K resistance. For clinical relevance we are also investigating PIK3CA mutants to determine if results observed from phosphoproteomic analyses in a PTEN-deficient model could be extended to models with other forms of PI3K pathway activation and resistance to other subtypes of PI3K inhibitors. Preliminary work has identified that PI3KCA mutant cell lines resistant to both fulvestrant and GDC-0941 show increased sensitivity to ATM inhibition. These findings promote further investigation as to ATM inhibition’s effects on PTEN deficient lines

Contribución al conocimiento de la vegetación de las montañas marroquíes

Different types of plant communities, till now undetected in Morocco, are here described using the phytosociological method. The following new subassociations and associations are proposed: Anthyllido polycephalae-Stachydetum fontqueri subass. quercetosum rotundifoliae is a machia from the Northern Rif Mountains; Genisto anglicae-Ericetum ciliaris subsass. pinguiculetosum lusitanicae is a heathland from the Bou Hassim range in the Western Rif; Cephalario maroccanae-Inuletum maletii is a megaphorbic community from the Middle Atlas; Bellis caerulescendis-Heracletum sphondyllii is a megaphorbic community from the High Atlas; Arenario armerinae-Sideritetum matris-fillae is a high mountain grassland from the Tichchoukt range in the Middle Atlas. New data are given for the syntaxa already described but with the distribution, variability and ecology not well known. This is the case of the following associations: Polysticho setiferi-Prunetum lusitanicae, a riverine woodland from the W Rif Mountains; Primulo acaulis-Betuletum celtibericae, a birch woodland from the C Rif and Astragaletum numidico-maroccani a high mediterranean mountain plant community from the Western Rif. As a conclusion, the vegetation of the peculiar habitats that occur in reduced areas is only partially known.Se describe con la metodología fitosociológica diferentes tipos de comunidades vegetales, no detectadas hasta el presente en Marruecos. Se proponen las siguientes nuevas asociaciones y subasociaciones: Anthyllido polycephalae-Stachydetum fontqueri subass. quercetosum rotundifoliae corresponde a una maquia de las montañas septentrionales del Rif; Genisto anglicae-Ericetum ciliaris subsass. pinguiculetosum lusitanicae es un brezal del macizo de Bou Hassim en el Rif occidental; Cephalario maroccanae- Inuletum maletii es una formación de megaforbios del Atlas Medio; Bellis caerulescendis-Heracletum sphondyllii es una formación de megaforbios del Gran Atlas; Arenario armerinae-Sideritetum matris-filiae es un pastizal de alta montaña mediterránea del macizo de Tichchoukt en el Atlas Medio. Se aportan nuevos datos para otros sintáxones ya descritos pero con la distribución, variabilidad y ecología poco conocidas. Este es el caso de las asociaciones siguientes: Polysticho setiferi-Prunetum lusitanicae, bosquecillo ripario de las montañas del Rif occidental y central; Primulo acaulis-Betuletum celtibericae, corresponde a un bosque de abedules del Rif central, y Astragaletum numidico-maroccani es una comunidad de caméfitos de alta montaña mediterránea conocida hasta el presente del Rif occidental. Como conclusión se puede aseverar que la vegetación de los hábitats que ocupan áreas reducidas en las montañas marroquíes es conocida de forma parcial

Influencia de las pr?cticas pedag?gicas en el desempe?o escolar en los estudiantes de tercero de primaria de la instituci?n educativa Jos? Ant?nio Ricaurte de Ibagu? - Tolima

144 p. Recurso Electr?nicoEste proyecto presenta los resultados de una investigaci?n realizada con el prop?sito de caracterizar las pr?cticas pedag?gicas de los docentes y determinar la influencia en el desempe?o escolar de los estudiantes del grado tercero de primaria de la instituci?n educativa Jos? Antonio Ricaurte de Ibagu? Tolima, de car?cter oficial. El estudio se aborda desde dos categor?as: pr?cticas pedag?gicas y desempe?o escolar. Las primeras vistas desde las concepciones de Zuluaga, (1999) y su grupo de investigaci?n ?Hacia la historia de las pr?cticas pedag?gicas en Colombia? (p. 1). Se tuvo en cuenta los elementos que individualizan las pr?cticas: instituci?n, sujeto y discurso, haciendo ?nfasis en el sujeto del saber pedag?gico: el docente. La segunda categor?a de an?lisis, enfocada desde la complejidad que sucede en las aulas de clase. La estrategia metodol?gica utilizada fue entrevistas semiestructurada a directivos docentes y docentes, encuestas a estudiantes que conformaron el grupo focal, observaci?n de clase no participante y revisi?n y an?lisis documental. Los resultados del estudio refieren a una instituci?n con avances significativos desde el punto de vista conceptual, un proyecto educativo institucional PEI, plan de estudios organizado por ?reas y estructurado seg?n los lineamientos y un sistema de evaluaci?n acorde a la ley y haciendo uso de su autonom?a. En cuanto a las pr?cticas pedag?gicas encontradas, es importante resignificar aspectos como la articulaci?n entre discursos, pr?cticas, modelo pedag?gico y PEI, unific?ndolas alrededor de intereses claros que respondan a los objetivos del proyecto educativo institucional y al contexto. Palabras claves: pr?cticas pedag?gicas, instituci?n, sujeto, discurso.This project presents the findings of a research carried out with the purpose of characterizing the pedagogical practices of the teachers and determining its influence on the students? performance of third graders from the public school Jose Antonio Ricaurte in Ibagu?, Tolima. The study is based on two categories: pedagogical practices and school performance. The first perspectives are taken from the conceptions of Zuluaga, (1999) and her research group "Towards the history of pedagogical practices in Colombia" (p. 1) where the elements that individualize the practices were taken into account: institution, subject, and discourse, emphasizing on the subject of pedagogical knowledge: the teacher. The second category of analysis is focused on the complexities that take place in the classrooms. The methodological strategies were used was semi-structured interviews to the principal, and teachers, interviews to students who were part of the focus group, class observation of non-participants, the revision and documentary analysis. The findings from the present study refer to an institution with significant advances from the conceptual conception, an institutional education project PEI, a well-organized curriculum by areas according to the guidelines and a system of evaluation according to the law, making use of its autonomy. Regarding the found pedagogical practices, it is important to resignify aspects such as the articulation between discourses, practices, pedagogical model and PEI, unifying them around clear interests that respond to the objectives proposed in the institutional educational project and the context Keywords: pedagogical practices, institution, subject, discourse

Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain

Objectives: To characterise antimicrobial use (AMU) per production stage in terms of drugs, routes of application, indications, duration and exposed animals in farrow-to-finish pig farms in Spain. Design: Survey using a questionnaire on AMU during the six months prior to the interview, administered in face-to-face interviews completed from April to October 2010. Participants: 108 potentially eligible farms covering all the country were selected using a multistage sampling methodology; of these, 33 were excluded because they did not fulfil the participation criteria and 49 were surveyed. Results: The rank of the most used antimicrobials per farm and production stage and administration route started with polymyxins (colistin) by feed during the growing and the preweaning phases, followed by β-lactams by feed during the growing and the preweaning phases and by injection during the preweaning phase. Conclusions: The study demonstrates that the growing stage (from weaning to the start of finishing) has the highest AMU according to different quantitative indicators (number of records, number of antimicrobials used, percentage of farms reporting use, relative number of exposed animals per farm and duration of exposure); feed is the administration route that produces the highest antimicrobial exposure based on the higher number of exposed animals and the longer duration of treatment; and there are large differences in AMU among individual pig farms

Towards an automation of the traceability of bugs from development logs: A study based on open source software

Context: Information and tracking of defects can be severely incomplete in almost every Open Source project, resulting in a reduced traceability of defects into the development logs (i.e., version control commit logs). In particular, defect data often appears not in sync when considering what developers logged as their actions. Synchronizing or completing the missing data of the bug repositories, with the logs detailing the actions of developers, would benefit various branches of empirical software engineering research: prediction of software faults, software reliability, traceability, software quality, effort and cost estimation, bug prediction and bug fixing. Objective: To design a framework that automates the process of synchronizing and filling the gaps of the development logs and bug issue data for open source software projects. Method: We instantiate the framework with a sample of OSS projects from GitHub, and by parsing, linking and filling the gaps found in their bug issue data, and development logs. UML diagrams show the relevant modules that will be used to merge, link and connect the bug issue data with the development data. Results: Analysing a sample of over 300 OSS projects we observed that around 1/2 of bug-related data is present in either development logs or issue tracker logs: the rest of the data is missing from one or the other source. We designed an automated approach that fills the gaps of either source by making use of the available data, and we successfully mapped all the missing data of the analysed projects, when using one heuristics of annotating bugs. Other heuristics need to be investigated and implemented. Conclusion: In this paper a framework to synchronise the development logs and bug data used in empirical software engineering was designed to automatically fill the missing parts of development logs and bugs of issue data