Kualitas Nutrisi dan Anti Nutrisi Pakan Cair Fermentasi Berbahan Biji Asam

Biji asam selain memiliki nutrien juga memiliki antinutrien tanin. Oleh karena itu fermentasi pakan cair perlu dilakukan dengan perbandingan air berbeda. Tujuan penelitian adalah mengkaji kandungan nutrisi dan anti nutrisi fermentasi pakan cair berbahan biji asam dengan perbandingan air berbeda. Bahan penelitian adalah biji asam utuh, dedak, jagung, tepung daging dan tulang, dan bungkil kacang kedelai dengan perbandingan air berbeda. Penelitian menggunakan rancangan acak lengkap dan terdiri dari 5 perlakuan dan 5 ulangan. Perlakuan adalah R0: ransum basal tanpa biji asam, R1: Ransum mengandung biji asam fermentasi, R2: R1 dengan perbandingan air 1:1, R3: R1 dengan perbandingan air 1:3, dan R4: R1 dengan perbandingan air 1:5. Variabel penelitian adalah bahan kering, protein kasar, serat kasar, Bahan Ekstrak Tanpa Nitrogen/BETN, lemak kasar, dan tannin. Data dianalisis menggunakan analisis varians dan uji lanjut Duncan. Hasil penelitian menunjukkan bahwa fermentasi pakan cair berbahan biji asam dengan perbandingan air berbeda berpengaruh sangat nyata  (P0,05) terhadap kandungan protein kasar, serat kasar, lemak kasar, BETN, dan abu. Perbandingan air pakan cair terbaik adalah 1:3. Kesimpulannya perbandingan air pakan cair fermentasi berbahan biji asam adalah 1:3 yang dapat menurunkan kandungan bahan kering protein kasar, abu, dan tanin serta meningkatkan BETN, serat kasar, dan lemak kasar

Stem cell therapy in animal models of central nervous system (CNS) diseases: therapeutic role, challenges and perspectives

ABSTRACT Many human diseases relating to central nervous system (CNS) are mimicked in animal models to evaluate the efficacy of stem cell therapy. The therapeutic role of stem cells in animal models of CNS diseases include replacement of diseased or degenerated neuron, oligodendrocytes or astrocytes with healthy ones, secretion of neurotrophic factors and delivery of therapeutics/genes. Scaffolds can be utilized for delivering stem cells in brain. Sustained delivery of stem cells, lineage specific differentiation, and enhanced neuronal network integration are the hallmarks of scaffold mediated stem cell delivery in CNS diseases. This review discusses the therapeutic role, challenges and future perspectives of stem cell therapy in animal models of CNS diseases

Differentiation and displacement: Unpicking the relationship between accounts of illness and social structure

This article seeks to unpack the relationship between social structure and accounts of illness. Taking dentine hypersensitivity as an example, this article explores the perspective that accounts of illness are sense-making processes that draw on a readily available pool of meaning. This pool of meaning is composed of a series of distinctions that make available a range of different lines of communication and action about such conditions. Such lines of communication are condensed and preserved over time and are often formed around a concept and its counter concept. The study of such processes is referred to as semantic analysis and involves drawing on the tools and techniques of conceptual history. This article goes on to explore how the semantics of dentine hypersensitivity developed. It illustrates how processes of social differentiation led to the concept being separated from the more dominant concept of dentine sensitivity and how it was medicalised, scientised and economised. In short, this study seeks to present the story of how society has developed a specific language for communicating about sensitivity and hypersensitivity in teeth. In doing so, it proposes that accounts of dentine hypersensitivity draw on lines of communication that society has preserved over time

Harga dan Estimasi Nilai Ekonomis Pakan Cair yang Mengandung Persentase Biji Asam Berbeda

One of the conventional feed ingredients commonly used as pig feed to reduce ration prices is tamarind seeds. However, tamarind seeds have a hard seed coat texture, therefore liquid feed is fermented by formulating it with other feed ingredients, in order to know whether the liquid feed has economic value or not. The purpose of this research is to examine the price of liquid feed containing different percentages of tamarind seeds and estimate their economic value in the form of total consumption costs and feed cost per gain. The research was using yellow corn, rice bran, soybean meal, meat and bone meal, whole tamarind seeds, and aquades. Liquid feed is formulated according to the needs of the grower phase of pigs. The research treatments were R0: Fermented liquid feed (FLF) containing 0% tamarind seeds, R10: FLF containing 10% tamarind seeds, R20: FLF containing 20% ​​tamarind seeds, and R30: FLF containing 30% tamarind seeds. The variables studied were the price of liquid feed (Rp/kg), total consumption cost (Rp/kg/e), and feed cost per gain (Rp). The data were analyzed descriptively according to the research variables. The results showed that the price of liquid feed, the total cost of consumption, and the cost of the R30 treatment feed were Rp. 6868/kg, Rp. 12,579,711/kg/e, and Rp. 18,177 lower or more economical than treatment R0, R10, and R20. It was concluded that the presentation of the use of tamarind seeds in liquid feed at a level of 30% was more profitable

Mesenchymal stem cells-seeded bio-ceramic construct for bone regeneration in large critical-size bone defect in rabbit

Bone marrow derived mesenchymal stem cells (BMSC) represent an attractive cell population for tissue engineering purpose. The objective of this study was to determine whether the addition of recombinant human bone morphogenetic protein (rliBMP-2) and insulin-like growth factor (IGF-1) to a silica-coated calcium hydroxyapatite (HASi)- rabbit bone marrow derived mesenchymal stem cell (rBlVISC) construct promoted bone healing in a large segmental bone defect beyond standard critical-size radial defects (15mm) in rabbits. An extensively large 30111111 long radial ostectomy was performed unilaterally in thirty rabbits divided equally in five groups. Defects were filled with a HASi scaffold only (group B), HASi scaffold seeded with rl3VISC (group C); HASi scaffold seeded with 113NISC along with rhl3MP-2 and IGF-1 in groups D and E respectively. The same number of rBMSC (five million cells) and concentration of growth factors rhBMP-2 (50ps) and IGF-1 (50g) was again injected at the site of bone defect after 15 days of surgery in their respective groups. An empty defect served as the control group (group A). Radiographically, bone healing was evaluated at 7, 15, 30, 45, 60 and 90 days post implantation. Histological qualitative analysis with microCT (pt-CT), haematoxylin and eosin (H & E) and Masson's trichrome staining were performed 90 days after implantation. All rhBMP-2-ackled constructs induced the formation of well-differentiated mineralized woven bone surrounding the HASi scaffolds and bridging bone/implant interfaces as early as eight weeks after surgery. Bone regeneration appeared to develop earlier with the rliBIAP-2 constructs than with the IGF-1 added construct. Constructs without any rItEMP-2 or IGF-1 showed osteoconductive properties limited to the bone junctions without bone ingrowths within the implantation site. In conclusion, the addition of rhBIVIP-2 to a HASi scaffold could promote bone generation large critical-size-defect