Coupling of actin hydrolysis and polymerization: Reduced description with two nucleotide states

The polymerization of actin filaments is coupled to the hydrolysis of adenosine triphosphate (ATP), which involves both the cleavage of ATP and the release of inorganic phosphate. We describe hydrolysis by a reduced two-state model with a cooperative cleavage mechanism, where the cleavage rate depends on the state of the neighboring actin protomer in a filament. We obtain theoretical predictions of experimentally accessible steady state quantities such as the size of the ATP-actin cap, the size distribution of ATP-actin islands, and the cleavage flux for cooperative cleavage mechanisms.Comment: 6 page

Automatic conditioning of the LHC injection kickers

The LHC injection systems, located near the interaction regions 2 and 8, comprise 4 fast pulsed kicker magnets (MKI) per ring to bring the beam onto the orbit. Each magnet is housed in a separate vacuum tank. Their nominal operating voltage is 54 kV, and the nominal pulse length 7.86 µs. To prepare these magnets for operation they are once assembled and baked out, gradually subjected to higher and higher voltages and greater pulse lengths, until their voltage holding capability is sufficiently beyond the nominal operating conditions. In the past this "conditioning" was carried out manually, and thus a manpower-intensive, and also technically not optimal procedure. To overcome these drawbacks a program has been developed, running in a Programmable Logic Controller (PLC), which has been used to condition the full suite of LHC injection kickers automatically

Control of the MKQA tuning and aperture kickers of the LHC

The large hadron collider (LHC) at CERN has been equipped with four fast pulsed kicker magnets in RA43 situated at point 4 which are part of the measurement system for the tune and the dynamic aperture of the LHC beam (Beam 1 and Beam 2). For the tune measurement 'Q', the magnets will excite oscillations in part of the beam. This is achieved by means of a generator producing a 5 µs base half-sine pulse of 1.2 kA [1] amplitude, superimposed with a 3rd harmonic to produce a 2 µs flat top. A kick repetition rate of 2 Hz will be possible. To measure the dynamic aperture 'A' of the LHC at different beam energies, the same magnets will also be driven by a more powerful generator which produces a 43 µs base half-sine current pulse of 3.8 kA. For the 'A' mode a thyristor is used as switching element inside the generator. A final third mode named 'AC dipole' will rely on the beam being excited coherently at a frequency close but outside its Eigen-frequencies by an oscillating dipole field. The beam is expected to oscillate at the exciter frequency of 3 kHz with a phase shift of π/2. The 'AC dipole' will use two 18 kW audio amplifiers capable of driving the magnets at 1 kHz(rms) around 3 kHz or between 2.7 kHz and 4 kHz. The complete system uses supervisory control implemented with Siemens PLC technology with added Siemens PROFIsafe safety feature to treat the various interlocks that have been introduced in the circuits and to assu re a safe functioning and provide 'LOCAL' and 'REMOTE' control (via CCC) of the complete installation

Instability driven fragmentation of nanoscale fractal islands

Formation and evolution of fragmentation instabilities in fractal islands, obtained by deposition of silver clusters on graphite, are studied. The fragmentation dynamics and subsequent relaxation to the equilibrium shapes are controlled by the deposition conditions and cluster composition. Sharing common features with other materials' breakup phenomena, the fragmentation instability is governed by the length-to-width ratio of the fractal arms.Comment: 5 pages, 3 figures, Physical Review Letters in pres

Basilar Artery Changes in Fabry Disease

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