Health risk assessment after exposure to aluminium in drinking water between two different villages.

A cross-sectional study was conducted at Mukim Parit Lubok (MPL) and Parit Raja (PR), Batu Pahat, Malaysia. The main objective of this study was to determine the aluminium concentration in drinking water and to perform health risk assessment prediction among respondents from these two residential areas. A total of 100 respondents were selected from the study areas based on inclusive and exclusive criteria. Two duplicates of treated water samples were taken from each respondent’s house using 200mL high-density polyethylene (HDPE) bottles and 0.4 mL (69%) pure concentrated nitric acid were added as a preservative. Aluminium concentrations were analyzed using a Lambda 25 UV/V spectrophotometer. The result showed that aluminium concentration in drinking water from MPL was 0.18 ± 0.022 mg/L and 0.22 ± 0.044 mg/L for PR. Statistical analysis showed that 14 (28%) water samples collected from MPL and 35 (70%) from PR recorded concentration of aluminium above the standard limit set by the Ministry of Health, Malaysia for drinking water guideline (0.2 mg/L). The mean value of Chronic Daily Intake (CDI) of aluminium in drinking water from PR (0.00707 mg/kg/day) was significantly higher compared to MPL (0.00164 mg/kg/day). Hazard Index (HI) calculation showed that all respondents had “HI” of less than 1. In conclusion, there was an unlikely potential for adverse health effects from aluminium intake in drinking water from both study areas. However, it was necessary for some actions to be taken in order to reduce aluminium levels found in drinking water for both locations

Strengthening user authentication for better protection of mobile application systems

For most of us now, life is incomplete if living without mobile phones. This is because mobile phones are like a necessity to many people nowadays. Statistics have shown that more than seven billion people in the world are having these devices in 2015. This also means 97% of the human world populations are actually mobile phone users. Besides, more than 50% of the mobile phone users are using smarts phones which are capable of downloading a lot of mobile application systems (apps). It is estimated that more than 200 million apps are being downloaded in 2007 and this number is believed to be growing. Unfortunately, many of these apps involve the transfer of important and confidential personal data or business information. How to ensure this sensitive information is well protected from being stolen or misused by unauthorized parties? One of the ways to secure this communication is to properly control the access to the system by strengthening the user authentication. Thus, this paper focuses on one the techniques to enhance the protections of mobile apps to prevent intrusions by unpermitted users. The enhancement is focusing on improving the multi-factor elements and the text ciphering technique of the user authentication. In this study, random number and time are added in the existing text-based multifactor user authentication. Besides, encryption and hash are used as the text ciphering technique to improve the protection. To measure how secure the proposed enhancement is, an independent testing body has been appointed to perform Vulnerability Test and Functionality Test to the apps. If all these tests are passed, it can be said that the proposed enhancement is strong enough to protect the apps from being intruded. Based on the test results provided by the testing body, CyberSecurity Malaysia, the apps has passed all the Vulnerability Test and Functionality Test. This shows that the control of the access to these apps are strong and able to prevent from being accessed by unpermitted users. This also means the proposed enhancement is able to give better protections to ensure the mobile apps can't be easily broken into by unauthorized mobile phone users

Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: The pilot phase of a randomised controlled trial

Summary: Background Preoperative (neoadjuvant) chemotherapy and radiotherapy are more eff ective than similar postoperative treatment for oesophageal, gastric, and rectal cancers, perhaps because of more eff ective micrometastasis eradication and reduced risk of incomplete excision and tumour cell shedding during surgery. The FOxTROT trial aims to investigate the feasibility, safety, and effi cacy of preoperative chemotherapy for colon cancer. Methods In the pilot stage of this randomised controlled trial, 150 patients with radiologically staged locally advanced (T3 with ≥5 mm invasion beyond the muscularis propria or T4) tumours from 35 UK centres were randomly assigned (2:1) to preoperative (three cycles of OxMdG [oxaliplatin 85 mg/m², l-folinic acid 175 mg, fl uorouracil 400 mg/m² bolus, then 2400 mg/m² by 46 h infusion] repeated at 2-weekly intervals followed by surgery and a further nine cycles of OxMdG) or standard postoperative chemotherapy (12 cycles of OxMdG). Patients with KRAS wild-type tumours were randomly assigned (1:1) to receive panitumumab (6 mg/kg; every 2 weeks with the fi rst 6 weeks of chemotherapy) or not. Treatment allocation was through a central randomisation service using a minimised randomisation procedure including age, radiological T and N stage, site of tumour, and presence of defunctioning colostomy as stratifi cation variables. Primary outcome measures of the pilot phase were feasibility, safety, and tolerance of preoperative therapy, and accuracy of radiological staging. Analysis was by intention to treat. This trial is registered, number ISRCTN 87163246. Findings 96% (95 of 99) of patients started and 89% (85 of 95) completed preoperative chemotherapy with grade 3–4 gastrointestinal toxicity in 7% (seven of 94) of patients. All 99 tumours in the preoperative group were resected, with no signifi cant diff erences in postoperative morbidity between the preoperative and control groups: 14% (14 of 99) versus 12% (six of 51) had complications prolonging hospital stay (p=0·81). 98% (50 of 51) of postoperative chemotherapy patients had T3 or more advanced tumours confi rmed at post-resection pathology compared with 91% (90 of 99) of patients following preoperative chemotherapy (p=0·10). Preoperative therapy resulted in signifi cant downstaging of TNM5 compared with the postoperative group (p=0·04), including two pathological complete responses, apical node involvement (1% [one of 98] vs 20% [ten of 50], p<0·0001), resection margin involvement (4% [ four of 99] vs 20% [ten of 50], p=0·002), and blinded centrally scored tumour regression grading: 31% (29 of 94) vs 2% (one of 46) moderate or greater regression (p=0·0001). Interpretation Preoperative chemotherapy for radiologically staged, locally advanced operable primary colon cancer is feasible with acceptable toxicity and perioperative morbidity. Proceeding to the phase 3 trial, to establish whether the encouraging pathological responses seen with preoperative therapy translates into improved long-term oncological outcome, is appropriate

A longitudinal study of farmers and trainers capturing climate information for sustainable development

Climate variability impacts negatively on the agricultural, social, environmental and economic well-being of rural communities. For example, severe droughts are commonly highlighted as having both short- and long-term impacts. Climate-based information needs to be integrated with a 'whole-farm' approach. Climate variability and climate change will become more prominent in importance. It is proposed that sound educational materials and process for extension staff and stakeholders in the rural community will improve knowledge and skills to better manage this variable climate. The expected benefits include: improved knowledge and skills, enhanced decisions and reduced climate risk exposure. This paper will discuss successes to date in applied climate education. It will discuss training in risk management strategies relating to agricultural systems and identify a future advanced training program. Educational implications for farmers and trainers will discuss the merits of a three-tiered training hierarchy aimed at fundamental, intermediate and advanced levels. The climate change challenge will require immediate and ongoing attention, with respect to applied climate education, targeting agriculture and natural resource management

Limited Wegener’s Granulomatosis with Predominant Otological Presentation

A young man presenting with complaints of progressive deafness in both ears with recent onset of facial paralysis was found to have necrotic debris in the nasal cavity. He was diagnosed to have limited form of Wegener’s granulomatosis on the basis of nasal biopsy. There was delay in diagnosis as the patient was having atypical and predominantly otological presentation of a potentially serious systemic disorder, Wegener’s granulomatosis. In this case report, emphasis was given on the necessity of comprehensive evaluation of the patients to avoid pitfalls in diagnosis

A Critical Analysis of Forest Policies of Pakistan: Implications for Sustainable Livelihoods

forest communities, forest management, forest policy, sustainable livelihoods,