62 research outputs found
Effect of rehabilitation exercise durations on the dynamic bone repair process by coupling polymer scaffold degradation and bone formation
Implantation of biodegradable scaffold is considered as a promising method to treat bone disorders, but knowledge of the dynamic bone repair process is extremely limited. In this study, based on the representative volume cell of a periodic scaffold, the influence of rehabilitation exercise duration per day on the bone repair was investigated by a computational framework. The framework coupled scaffold degradation and bone remodeling. The scaffold degradation was described by a function of stochastic hydrolysis independent of mechanical stimulation, and the bone formation was remodeled by a function of the mechanical stimulation, i.e., strain energy density. Then, numerical simulations were performed to study the dynamic bone repair process. The results showed that the scaffold degradation and the bone formation in the process were competitive. An optimal exercise duration per day emerged. All exercise durations promoted the bone maturation with a final Young's modulus of 1.9 ± 0.3 GPa. The present study connects clinical rehabilitation and fundamental research, and is helpful to understand the bone repair process and further design bone scaffold for bone tissue engineering
Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy
Umgang mit deutschem Reaktorplutonium im europäischen Kontext: Beitrag zum Hauptvortrag bei der Frühjahrstagung der Deutschen Physikalischen Ges., Dresden 2000
Der Umgang mit zivilen Plutoniumbeständen aus Sicht der Nichtverbreitung kernwaffenfähiger Materialien
Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular Phenotyping in Mice
Fortgeschrittene Nuklearsysteme: was ist zu erwarten? Beitrag zum Hauptvortrag bei d. FrĂĽhjahrstagung der Deutschen Physikal. Ges., Dresden 2000
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