121 research outputs found
Relationships between the concentrations of epidermal growth factor, insulin-like growth factor-I, estrogens and progesterone receptors in women breast cancer, and the histologic type of tumor and its grade of malignancy
A cross sectional study of water quality from dental unit water lines in dental practices in the West of Scotland
OBJECTIVE: To determine the microbiological quality of water from dental units in a general practice setting and current practice for disinfection of units. DESIGN: A cross-sectional study of the water quality from 40 dental units in 39 general practices and a questionnaire of the disinfection protocols used in those practices. SETTING: NHS practices in primarydental care. SUBJECTS: Thirty-nine general practices from the West of Scotland. METHODS: Water samples were collected on two separate occasions from dental units and analysed for microbiological quality by the total viable count (TVC) method. Water specimens were collected from the triple syringe, high speed outlet, cup filler and surgery tap. Each participating practitioner was asked to complete a questionnaire. Results Microbial contamination was highest from the high speed outlet followed by the triple syringe and cup filler. On average, the TVC counts from the high speed water lines at 37 degrees C and for the high speed lines, triple syringe and cup filler at 22 degrees C were significantly higher than that from the control tap water specimens. The study included units from 11 different manufacturers with ages ranging from under one year to over eight years. The age of the dental unit analysed did not appear to influence the level of microbial contamination. Five of the practices surveyed used disinfectants to clean the dental units but these had no significant effect on the microbiological quality of the water. The majority of dental units (25 out of 40) were never flushed with water between patients. A number of different non-sterile irrigants were used for surgical procedures. CONCLUSION: The microbiological quality of water from dental units in general dental practice is poor compared with that from drinking water sources. Suitable sterile irrigants should be used for surgical procedures in dental practice. Further work is required for pragmatic decontamination regimens of dental unit water lines in a general dental practice setting
Interparticle Potential up to Next-to-leading Order for Gravitational, Electrical, and Dilatonic Forces
Long-range forces up to next-to-leading order are computed in the framework
of the Einstein-Maxwell-dilaton system by means of a semiclassical approach to
gravity. As has been recently shown, this approach is effective if one of the
masses under consideration is significantly greater than all the energies
involved in the system. Further, we obtain the condition for the equilibrium of
charged masses in the system.Comment: 19 pages, 19 figures, RevTeX4.1. Revised version, Title change
Contribution to the flora of Asian and European countries : new national and regional vascular plant records, 9
Lattice dynamics localization in low-angle twisted bilayer graphene
A low twist angle between the two stacked crystal networks in bilayer
graphene enables self-organized lattice reconstruction with the formation of a
periodic domain. This superlattice modulates the vibrational and electronic
structures, imposing new rules for electron-phonon coupling and the eventual
observation of strong correlation and superconductivity. Direct optical images
of the crystal superlattice in reconstructed twisted bilayer graphene are
reported here, generated by the inelastic scattering of light in a nano-Raman
spectroscope. The observation of the crystallographic structure with visible
light is made possible due to lattice dynamics localization, the images
resembling spectral variations caused by the presence of strain solitons and
topological points. The results are rationalized by a nearly-free-phonon model
and electronic calculations that highlight the relevance of solitons and
topological points, particularly pronounced for structures with small twist
angles. We anticipate our discovery to play a role in understanding Jahn-Teller
effects and electronic Cooper pairing, among many other important
phonon-related effects, and it may be useful for characterizing devices in the
most prominent platform for the field of twistronics.Comment: 9 pages, 8 figure
Chromosome characterization and variability in some Iridaceae from Northeastern Brazil
The chromosomes of 15 species of Iridaceae of the genera Alophia, Cipura, Eleutherine, Neomarica and Trimezia (subfamily Iridoideae) were examined after conventional Giemsa staining. The karyotypes of Alophia drummondii (2n = 14+1B, 28, 42 and 56), Cipura paludosa (2n = 14), C. xanthomelas (2n = 28) and Eleutherine bulbosa (2n = 12) were asymmetric; Neomarica candida, N. caerulea, N. humilis, N. glauca, N. gracilis, N. northiana and Neomarica sp. (2n = 18); N. cf. paradoxa (2n = 28), Trimezia fosteriana (2n = 52), T. martinicensis (2n = 54) and T. connata (2n = 82) were all generally symmetric. New diploid numbers of 2n = 56 for Alophia drummondii, 2n = 18 for N. candida, N. humilis, N. glauca, and N. gracilis, 2n = 28 for N. cf. paradoxa, and 2n = 82 for T. connata are reported. The karyotypic evolution of the studied species is discussed
Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action
Due to their favourable tolerability profiles, endocrine therapies have long been considered the treatment of choice for hormone-sensitive metastatic breast cancer. However, the oestrogen agonist effects of the available selective oestrogen receptor modulators, such as tamoxifen, and the development of cross-resistance between endocrine therapies with similar modes of action have led to the need for new treatments that act through different mechanisms. Fulvestrant (‘Faslodex’) is the first of a new type of endocrine treatment – an oestrogen receptor (ER) antagonist that downregulates the ER and has no agonist effects. This article provides an overview of the current understanding of ER signalling and illustrates the unique mode of action of fulvestrant. Preclinical and clinical study data are presented in support of the novel mechanism of action of this new type of ER antagonist
Evaluation of the photodynamic activity of Xanthene Dyes on Artemia salina described by chemometric approaches
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