Baseline Leptin Levels Predict Change in Leptin Levels During Weight Loss in Obese Breast Cancer Survivors

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73051/1/j.1524-4741.2007.00397.x.pd

The Potential for Chemotherapy-Free Strategies in Advanced Prostate Cancer

The treatment landscape for advanced prostate cancer is evolving rapidly, with new agents and strategies, and more optimal use of existing therapies under constant development. Efforts were focused on better understanding of the biology of the disease. This effort has paved the way for a more contemporary and effective therapies to be developed. There are now 6 FDA-approved therapies that increase overall survival. These include the immunotherapy sipuleucel-T; the 2 androgen pathway inhibitors: abiraterone acetate and enzalutamide; 2 chemotherapy drugs: docetaxel and cabazitaxel; and the radionuclide: radium-223. Advanced prostate cancer may be one of the few cancers for which multiple chemotherapy and nonchemotherapy regimens are considered as standard. Several recently published clinical trials have demonstrated the suprising activity of chemotherapy-free strategies, and we should not be too eager to discount these "old-fashioned" treatments. Optimal sequencing is still unclear because new therapies have proliferated so quickly that comparative data are limited. In this short communication, we identify current challenges and unmet needs in advanced prostate cancer and provide an overview of their respective clinical activity, while highlighting distinctions between therapies

Hepatotoxicity of vascular endothelial growth factor receptor tyrosine kinase inhibitors: clinical practice and evidence

Vascular endothelial growth factor (VEGF) plays an important role in the growth of tumor cells, and in their invasion, metastasis, and angiogenesis. Kinase inhibitors (which are taken orally, work intracellularly, and can inhibit one or more kinases) constitute a rapidly growing and important part of the oncology armamentarium. Although these treatments have dramatically changed the natural course of many cancers, they may result in hepatic complications, which can be manifested during the course of therapy. More effort must be devoted to manipulating the dose and schedule of kinase inhibitor therapy to maximize efficacy and minimize toxicity. When these agents are used, judicious management of adverse effects should be carried out in the early phases of treatment. This article focuses on the hepatocellular toxic effects that may be associated with these new targeted cancer therapies and provides a broad overview of this emerging field. © 2017, Springer International Publishing AG Switzerland