Mobile Self-Efficacy in a Canadian Nursing Education Program

The purpose of this study was to assess the self-efficacy of nursing faculty and students related to their potential use of mobile technology and to ask what are the implications for their teaching and learning in practice education contexts. We used a cross-sectional survey design involving students and faculty in two nursing education programs in a Western Canadian college. 121 faculty members and students completed the survey in January, 2011. Results showed a high level of ownership and use of mobile devices among our respondents. Their median mobile self-efficacy score was 75 on a scale of 100, indicating that they are highly confident in their use of mobile technologies and prepared to engage in mobile learning

Mobile Self Efficacy in Canadian Nursing Education Programs

The purpose of this study was to assess the self-efficacy of nursing faculty and students related to their potential use of mobile technology and to ask what are the implications for their teaching and learning in practice education contexts. We used a cross-sectional survey design involving students and faculty in three separate nursing education programs in Western Canada. Fifty-six faculty members and students completed the survey in March, 2010. Results showed a high level of ownership and use of mobile devices among our respondents. Their overall average mobile self-efficacy score was 72.11 on a scale of 100, indicating that they are highly confident in their use of mobile technologies and prepared to engage in mobile learning

Using Self-Efficacy to Assess the Readiness of Nursing Educators and Students for Mobile Learning

The purpose of this study was to assess the self-efficacy of nursing faculty and students related to their potential use of mobile technology and to ask what implications this technology has for their teaching and learning in practice education contexts. We used a cross-sectional survey design involving students and faculty in two nursing education programs in a western Canadian college. In January, 2011, 121 faculty members and students completed the survey. Results showed a high level of ownership and use of mobile devices among our respondents. The median mobile self-efficacy score was 75 on a scale of 100, indicating that both faculty and students were highly confident in their use of mobile technologies and prepared to engage in mobile learning

Mobile Learning in Nursing Practice Education: Applying Koole's FRAME Model

We report here on an exploratory formative evaluation of a project to integrate mobile learning into a Western Canadian college nursing program. Third-year students used Hewlett Packard iPAQ mobile devices for five weeks in a practice education course in April—May, 2007. Koole's (2009) Framework for the Rational Analysis of Mobile Education (FRAME) model provided our definition of mobile learning and was used to organize our presentation of the results of the study. Participants reported positively on the usability of the mobile devices, finding them easy to learn, readily portable, and the screen size sufficient for mobile specific programs. However, they had difficulty with the wireless connectivity and, despite an initial orientation, did not have time to fully learn the devices in the context of a busy course. As a result, it is not clear if students can effectively use the social technology provided by such devices or if mobile learning can support interaction between instructors and learners in this context. The use of mobile devices in nursing practice education is feasible, but further investigation is needed on the use of m-learning for communication and interactive purposes

Using Mobile Learning to Enhance the Quality of Nursing Practice Education

In this chapter, we first review the research literature pertaining to the use of mobile devices in nursing education and assess the potential of mobile learning (m-learning) for nursing practice education experiences in rural higher education settings. While there are a number of definitions of m-learning, we adopted Koole’s (2005) FRAME model, which describes it as a process resulting from the convergence of mobile technologies, human learning capacities, and social interaction, and use it as a framework to assess this literature. Second, we report on the results of one-on-one trials conducted during the first stage of a two stage, exploratory evaluation study of a project to integrate mobile learning into the Bachelor of Science Nursing curriculum in a Western Canadian college program. Fourth year Nursing students and instructors used Hewlett Packard iPAQ PDAs for a two week period around campus and the local community. The iPAQs provided both WiFi and GPRS wireless capability and were loaded with selected software, including MS Office Mobile, nursing decision-making and drug reference programs. Our participants reported on a variety of benefits and barriers to the use of these devices in nursing practice education

Evaluation of an epigenetic assay for predicting repeat prostate biopsy outcome in African American men

OBJECTIVE: To evaluate an epigenetic assay performed on tissue from negative prostate biopsies in a group of African American (AA) men undergoing repeat biopsy, and to compare accuracy for predicting repeat biopsy outcome to prior studies conducted in predominantly Caucasian populations. MATERIALS AND METHODS: The study population consisted of 211 AA men from 7 urology centers across the United States; all of whom were undergoing 12-core transrectal ultrasound-guided repeat biopsy within 30 months from a negative index biopsy. All biopsy cores from the negative index biopsy were profiled for the epigenetic biomarkers GSTP1, APC, and RASSF1 using ConfirmMDx for Prostate Cancer (MDxHealth, Irvine, CA). RESULTS: Upon repeat biopsy, 130 of 211 subjects (62%) had no prostate cancer (PCa) detected and 81 of 211 (38%) were diagnosed with PCa. Of the subjects with PCa, 54 (67%) were diagnosed with Gleason score (GS) = 7 disease. For detection of PCa at repeat biopsy, ConfirmMDx sensitivity was 74.1% and specificity was 60.0%, equivalent to prior studies (P = .235 and .697, respectively). For detection of GS >= 7 PCa, sensitivity was 78% and specificity was 53%. The negative predictive values for detection of all PCa and GS >= 7 PCa were 78.8% and 94.2%, respectively. CONCLUSION: In this group of AA men, we successfully validated an epigenetic assay to assess the need for repeat biopsy. Results were consistent with previous studies from predominantly Caucasian populations. Therefore, the ConfirmMDx assay is a useful tool for risk stratification of AA men who had an initial negative biopsy

Friction and wear of human hair fibres

An experimental study of the tribological properties of hair fibres is reported, and the effect of surface treatment on the evolution of friction and wear during sliding. Specifically, orthogonally crossed fibre/fibre contacts under a compressive normal load over a series of 10,000 cycle studies are investigated. Reciprocating sliding at a velocity of 0.4 mm/s−1, over a track length of 0.8 mm, was performed at 18oC and 40-50% relative humidity. Hair fibres retaining their natural sebum were studied, as well as those stripped of their sebum via hexane cleaning, and hair fibres conditioned using a commercially available product. Surface topography modifications resulting from wear were imaged using scanning electron microscopy and quantified using white light interferometry. Hair fibres that presented sebum or conditioned product at the fibre/fibre junction exhibited initial coefficients of friction at least 25% lower than those that were cleaned with hexane. Coefficients of friction were observed to depend on the directionality of sliding for hexane cleaned hair fibres after sufficient wear cycles that cuticle lifting was present, typically on the order 1,000 cycles. Cuticle flattening was observed for fibre/fibre junctions exposed to 10 mN compressive normal loads, whereas loads of 100 mN introduced substantial cuticle wear and fibre damage

Array-Based DNA Methylation Profiling for Breast Cancer Subtype Discrimination

BACKGROUND: Abnormal DNA methylation is well established for breast cancer and contributes to its progression by silencing tumor suppressor genes. DNA methylation profiling platforms might provide an alternative approach to expression microarrays for accurate breast tumor subtyping. We sought to determine whether the distinction of the inflammatory breast cancer (IBC) phenotype from the non-IBC phenotype by transcriptomics could be sustained by methylomics. METHODOLOGY/PRINCIPAL FINDINGS: We performed methylation profiling on a cohort of IBC (N = 19) and non-IBC (N = 43) samples using the Illumina Infinium Methylation Assay. These results were correlated with gene expression profiles. Methylation values allowed separation of breast tumor samples into high and low methylation groups. This separation was significantly related to DNMT3B mRNA levels. The high methylation group was enriched for breast tumor samples from patients with distant metastasis and poor prognosis, as predicted by the 70-gene prognostic signature. Furthermore, this tumor group tended to be enriched for IBC samples (54% vs. 24%) and samples with a high genomic grade index (67% vs. 38%). A set of 16 CpG loci (14 genes) correctly classified 97% of samples into the low or high methylation group. Differentially methylated genes appeared to be mainly related to focal adhesion, cytokine-cytokine receptor interactions, Wnt signaling pathway, chemokine signaling pathways and metabolic processes. Comparison of IBC with non-IBC led to the identification of only four differentially methylated genes (TJP3, MOGAT2, NTSR2 and AGT). A significant correlation between methylation values and gene expression was shown for 4,981 of 6,605 (75%) genes. CONCLUSIONS/SIGNIFICANCE: A subset of clinical samples of breast cancer was characterized by high methylation levels, which coincided with increased DNMT3B expression. Furthermore, an association was observed with molecular signatures indicative of poor patient prognosis. The results of the current study also suggest that aberrant DNA methylation is not the main force driving the molecular biology of IBC

Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor molecule DNAX-activating protein of 10 kDa (DAP10) to provide co-stimulatory signal upon ligand binding. NKG2D binds eight different ligands expressed on the cell surface of many tumour cells and which are normally absent on non-neoplastic cells. In preclinical studies, NKR-2 demonstrated long-term antitumour activity towards a breadth of tumour indications, with maximum efficacy observed after multiple NKR-2 administrations. Importantly, NKR-2 targeted tumour cells and tumour neovasculature and the local tumour immunosuppressive microenvironment and this mechanism of action of NKR-2 was established in the absence of preconditioning. Methods and analysis: This open-label phase I study will assess the safety and clinical activity of NKR-2 treatment administered three times, with a 2-week interval between each administration in different tumour types. The study will contain two consecutive segments: a dose escalation phase followed by an expansion phase. The dose escalation study involves two arms, one in solid tumours (five specific indications) and one in haematological tumours (two specific indications) and will include three dose levels in each arm: 3x10(8), 1x10(9) and 3x10(9) NKR-2 per injection. On the identification of the recommended dose in the first segment, based on dose-limiting toxicity occurrences, the study will expand to seven different cohorts examining the seven different tumour types separately. Clinical responses will be determined according to standard Response Evaluation Criteria In Solid Tumors (RECIST) criteria for solid tumours or international working group response criteria in haematological tumours. Ethics approval and dissemination: Ethical approval has been obtained at all sites. Written informed consent will be taken from all participants. The results of this study will be disseminated through presentation at international scientific conferences and reported in peer-reviewed scientific journals

The feasibility of using mobile devices in nursing practice education

This paper focuses on an exploratory evaluation of the use of m-learning in nursing education. We report on Stage 2 of the formative evaluation of a project to integrate mobile learning into the Bachelor of Science Nursing curriculum in a Western Canadian college program. Third year nursing students and instructors used Hewlett Packard iPAQs for five weeks in a practice education course in April - May, 2007. The iPAQs provided WiFi and GPRS wireless capability and were loaded with programs such as Microsoft Office Mobile 6.0 and the 2007 Lippincott Nursing Drug Guide. Our participants found the mobile devices supplied to be easy to learn and comfortable to use. They felt that the devices were readily portable and the screen size sufficient for programs designed for this medium. However, they nonetheless had difficulty using the wireless connectivity afforded by the devices and found that, despite an initial orientation, they did not have time to fully learn the devices in the context of a busy course. We concluded that it was feasible to implement mobile devices in nursing practice education, but that further investigation is needed on the use of m-learning for communication and interactive purposes