Suppressor cell mediated regulation of delayed-type hypersensitivity to histocompatibility antigens

DTH to allogeneic histocompatibility antigens is a T cell dependent reaction, which can be induced in immunologically competent individuals by subcutaneous (s.c.) or intravenous (i.v.) administration of alloantigens (Vander Kwast and Benner, 1978; Bianchi et al., 1984). After immunization, activated antigen-specific T cells and, possibly, T cell derived factors circulate through the body and mediate an effective immune-surveillance. After reencounter with the specific antigen, for example after injection of the relevant allogeneic spleen cells into a hind foot, these T cells or their factors cause the release of vasoactive substances, which lead to the accumulation of granulocytes, mononuclear cells and edemic fluid. This inflammatory response appears as a swelling of the site of reencounter of the antigen, which is maximal between 24 and 96 hours after antigen administration. The delayed onset distinguishes DTH from the more immediate types of hypersensitivity. DTH can also be induced in immunologically incompetent individuals, by the infusion of allogeneic, immunocompetent T cells. This leads to a state of DTH directed to the host histocompatibility antigens (Wolters and Benner, 1978). Anti-host DTH can be assayed by secondary transfer of lymphoid cells from the irradiated recipients to naive secondary recipients, syngeneic to the original spleen cell donors. The secondary recipients are subsequently challenged in a hind foot with spleen cells expressing the alloantigens of the primary irradiated recipients. The T cells that mediate DTH probably represent a subset of Th cells (Bianchi et al., 1981; Mossman and Coffman, 1987), although certain cloned Tc cells mediating DTH have been described (Lin and Askonas, 1981; Weiss and Dennert, 1981)

RF Issues and Developments at the LHC Machine

The main RF system of the LHC, which uses 400MHz superconducting cavities, will be used to capture, accelerate and store the injected beam. A separate transverse damper system using electrostatic deflectors will be used to damp transverse oscillations. The associated low-level RF (LLRF) equipment is responsible for fast control of the accelerating voltage and phase in the cavities, the phase and radial position of the beam, and the synchronization of beam transfers between SPS and LHC. The LLRF system combines highfrequency analogue components with digital signal processing using FPGAs and DSPs. The extensive use of digital technology allows not only to achieve the required performance and stability but also to provide full remote control and diagnostics facilities needed in a machine where most of the RF system is inaccessible during operation

Commissioning and performance of a phase-compensated optical link for the AWAKE experiment at CERN

In this work, we analyze the performance of the solution adopted for the compensation of the phase drift of a 3 km optical fiber link used for the AWAKE experiment at CERN. The link is devoted to transmit the reference signals used to synchronize the SPS beam with the experiment to have a fixed phase relation, regardless of the external conditions of the electronics and the link itself. The system has been operating for more than a year without observed drift in the beam phases. Specific measurements have proven that the jitter introduced by the system is lower than 0.6 ps and the maximum phase drift of the link is at the picosecond level.Comment: Poster presented at LLRF Workshop 2017 (LLRF2017, arXiv:1803.07677

Studies of RF Noise Induced Bunch Lengthening at the LHC

Radio Frequency noise induced bunch lengthening can strongly affect the Large Hadron Collider performance through luminosity reduction, particle loss, and other effects. Models and theoretical formalisms demonstrating the dependence of the LHC longitudinal bunch length on the RF station noise spectral content have been presented*,**. Initial measurements validated these studies and determined the performance limiting RF components. For the existing LHC LLRF implementation the bunch length increases with a rate of 1 mm/hr, which is higher than the intrabeam scattering diffusion and leads to a 27% bunch length increase over a 20 hour store. This work presents measurements from the LHC that better quantify the relationship between the RF noise and longitudinal emittance blowup. Noise was injected at specific frequency bands and with varying amplitudes at the LHC accelerating cavities. The experiments presented in this paper confirmed the predicted effects on the LHC bunch length due to both the noise around the synchrotron frequency resonance and the noise in other frequency bands aliased down to the synchrotron frequency by the periodic beam sampling of the accelerating voltage

Digital Design Of The LHC Low Level rf: The Tuning System For The Superconducting Cavities

The low level RF systems for the LHC are based extensively on digital technology, not only to achieve the required performance and stability but also to provide full remote control and diagnostics facilities needed since most of the RF system is inaccessible during operation. The hardware is based on modular VME with a specially designed P2 backplane for timing distribution, fast data interchange and low noise linear power supplies. Extensive design re-use and the use of graphic FPGA design tools have streamlined the design process. A milestone was the test of the tuning system for the superconducting cavities. The tuning control module is based on a 2M gate FPGA with on-board DSP. Its design and functionality are described, including features such as automatic cavity measurements. Work is ongoing on completion of other modules and building up complete software and diagnostics facilities

Commissioning of the 400 MHz LHC RF System

The installation of the 400 MHz superconducting RF system in LHC is finished and commissioning is under way. The final RF system comprises four cryo-modules each with four cavities in the LHC tunnel straight section round IP4. Also underground in an adjacent cavern shielded from the main tunnel are the sixteen 300 kW klystron RF power sources with their high voltage bunkers, two Faraday cages containing RF feedback and beam control electronics, and racks containing all the slow controls. The system and the experience gained during commissioning will be described. In particular, results from conditioning the cavities and their movable main power couplers and the setting up of the low level RF feedbacks will be presented

LHC Beam Diffusion Dependence on RF Noise: Models and Measurements

Radio Frequency (RF) accelerating system noise and non-idealities can have detrimental impact on the LHC performance through longitudinal motion and longitudinal emittance growth. A theoretical formalism has been developed to relate the beam and RF loop dynamics with the bunch length growth [1]. Measurements were conducted at LHC to validate the formalism, determine the performance limiting RF components, and provide the foundation for beam diffusion estimates for higher energies and intensities. A brief summary of these results is presented in this work

Specialty-based, voluntary incident reporting in neonatal intensive care: description of 4846 incident reports

OBJECTIVES: To examine the characteristics of incidents reported after introduction of a voluntary, non-punitive incident reporting system for neonatal intensive care units (NICUs) in the Netherlands; and to investigate which types of reported incident pose the highest risk to patients in the NICU. DESIGN: Prospective multicentre survey. METHODS: Voluntary, non-punitive incident reporting was introduced in eight level III NICUs and one paediatric surgical ICU. An incident was defined as any unintended event which (could have) reduced the safety margin for the patient. Multidisciplinary, unit-based patient safety committees systematically collected and analysed incident reports, and assigned risk scores to each reported incident. Data were centrally collected for specialty-based analysis. This paper describes the characteristics of incidents reported during the first year. Bivariate logistic regression analysis was conducted to identify high-risk incident categories. RESULTS: There were 5225 incident reports on 3859 admissions, of which 4846 were eligible for analysis. Incidents with medication were most frequently reported (27%), followed by laboratory (10%) and enteral nutrition (8%). Severe harm was described in seven incident reports, and moderate harm in 63 incident reports. Incidents involving mechanical ventilation and blood products were most likely to be assigned high-risk scores, followed by those involving parenteral nutrition, intravascular lines and medication dosing errors. CONCLUSIONS: Incidents occur much more frequently in Dutch NICUs than has been previously observed, and their impact on patient morbidity is considerable. Reported incidents concerning mechanical ventilation, blood products, intravascular lines, parenteral nutrition and medication dosing errors pose the highest risk to patients in the NIC