The Chemical Evolution of the Milky Way: the Three Infall Model

We present a new chemical evolution model for the Galaxy that assumes three main infall episodes of primordial gas for the formation of halo, thick and thin disk, respectively. We compare our results with selected data taking into account NLTE effects. The most important parameters of the model are (i) the timescale for gas accretion, (ii) the efficiency of star formation and (iii) a threshold in the gas density for the star formation process, for each Galactic component. We find that, in order to best fit the features of the solar neighbourhood, the halo and thick disk must form on short timescales (~0.2 and ~1.25 Gyr, respectively), while a longer timescale is required for the thin-disk formation. The efficiency of star formation must be maximum (10 Gyr-1) during the thick-disk phase and minimum (1 Gyr-1) during the thin-disk formation. Also the threshold gas density for star formation is suggested to be different in the three Galactic components. Our main conclusion is that in the framework of our model an independent episode of accretion of extragalactic gas, which gives rise to a burst of star formation, is fundamental to explain the formation of the thick disk. We discuss our results in comparison to previous studies and in the framework of modern galaxy formation theories.Comment: 12 pages, 7 figures, accepted for publication in MNRA

Core-competitive Auctions

One of the major drawbacks of the celebrated VCG auction is its low (or zero) revenue even when the agents have high value for the goods and a {\em competitive} outcome could have generated a significant revenue. A competitive outcome is one for which it is impossible for the seller and a subset of buyers to `block' the auction by defecting and negotiating an outcome with higher payoffs for themselves. This corresponds to the well-known concept of {\em core} in cooperative game theory. In particular, VCG revenue is known to be not competitive when the goods being sold have complementarities. A bottleneck here is an impossibility result showing that there is no auction that simultaneously achieves competitive prices (a core outcome) and incentive-compatibility. In this paper we try to overcome the above impossibility result by asking the following natural question: is it possible to design an incentive-compatible auction whose revenue is comparable (even if less) to a competitive outcome? Towards this, we define a notion of {\em core-competitive} auctions. We say that an incentive-compatible auction is $\alpha$-core-competitive if its revenue is at least $1/\alpha$ fraction of the minimum revenue of a core-outcome. We study the Text-and-Image setting. In this setting, there is an ad slot which can be filled with either a single image ad or $k$ text ads. We design an $O(\ln \ln k)$ core-competitive randomized auction and an $O(\sqrt{\ln(k)})$ competitive deterministic auction for the Text-and-Image setting. We also show that both factors are tight

Molecular approach to quantitative inheritance

International audienc

Post-Mortem Immunohistochemical Evidence of β2-Adrenergic Receptor Expression in the Adrenal Gland

The evidence from post-mortem biochemical studies conducted on cortisol and catecholamines suggest that analysis of the adrenal gland could provide useful information about its role in human pathophysiology and the stress response. Authors designed an immunohistochemical study on the expression of the adrenal β2-adrenergic receptor (β2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. The immunohistochemical study was performed on adrenal glands obtained from 48 forensic autopsies of subjects that died as a result of different pathogenic mechanisms using a mouse monoclonal β2-AR antibody. The results show that immunoreactivity for β2-AR was observed in all adrenal zones. Furthermore, immunoreactivity for β2-AR has shown variation in the localization and intensity of different patterns in relation to the original cause of death. To the best of our knowledge, this is the first study that demonstrates β2-AR expression in the human cortex and provides suggestions on the possible involvement of β2-AR in human cortex hormonal stimulation. In conclusion, the authors provide a possible explanation for the observed differences in expression in relation to the cause of death

Erythema-directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris.

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Re: Critical Analysis of Early Recurrence after Laparoscopic Radical Cystectomy in a Large Cohort by the ESUT

okThe authors critically analyze a large cohort by the European Association of Urology Section of Uro-Technology and assess early recurrences after laparoscopic radical cystectomy and evaluation of risk factors, including the impact of pneumoperitoneum. They focus their analysis on patients with favorable pathology (pT2 N0 R0 disease), \ufb01nding that 27 of 311 patients (8.7%) experienced recurrences during the following 24 months. Surgical negligence was observed in only 1 patient, which was associated with the endo bag rupturing during transvaginal extraction with subsequent vulvar and peritoneal tumor metastasis after 4 months. Among the 27 patients with recurrence a shorter recurrence-free survival was signi\ufb01cantly predictive of cancer speci\ufb01c death (HR 0.86, 95% CI 0.78e0.94, p \ubc 0.001) as well as carcinoma in situ on pathological examination (HR 3.68, 95% CI 1.07e12.7, p \ubc 0.039). While analyzing causes of early recurrence, the authors suggest that the continuous insuf\ufb02ation-desuf\ufb02ation and leakage of gas around the portsdwith consequent aspiration of tumor cells via a chimney effectdmay promote tumor seeding (TS)

Fundamental Cycles and Graph Embeddings

In this paper we present a new Good Characterization of maximum genus of a graph which makes a common generalization of the works of Xuong, Liu, and Fu et al. Based on this, we find a new polynomially bounded algorithm to find the maximum genus of a graph

Cosmetics for acne: indications and recommendations for an evidence-based approach.

AIM: The aim of this review was to evaluate, by a thorough revision of the literature, the true efficacy of currently available topic and systemic cosmetic acne agents. METHODS: The efficacy of currently available cosmetic acne agents has been retrospectively evaluated via thorough revision of the literature on matched electronic databases (PubMed). All retrieved studies, either randomized clinical trials or clinical trials, controlled or uncontrolled were considered. RESULTS: Scientific evidence suggests that most cosmetic products for acne may enhance the clinical outcome. Cleansers should be indicated to all acne patients; those containing benzoyl peroxide or azelaic/salicylic acid/triclosan show the best efficacy profile. Sebum-controlling agents containing nicotinamide or zinc acetate may minimize excessive sebum production. Cosmetics with antimicrobial and anti-inflammatory substances such as, respectively, ethyl lactate or phytosphingosine and nicotinamide or resveratrol, may speed acne recovery. Topical corneolytics, including retinaldehyde/glycolic acid or lactic acid, induce a comedolytic effect and may also facilitate skin absorption of topical drugs. Finally, the use of specific moisturizers should be strongly recommended in all acne patients. CONCLUSION: Cosmetics, if correctly prescribed, may improve the performance of the therapy, whereas wrong procedures and/or inadequate cosmetics may worsen acne. Cosmetological recommendations may allow clinicians to make informed decisions about the role of various cosmetics and to indentify the appropriate indications and precautions. The choice of the most effective product should take into consideration the ongoing pharmacological therapy and acne type/severity as well

Management of a pregnant woman with fibromuscular dysplasia

No abstract available