Investigation into the steering ability problems of compact hovercrafts

The present paper investigates the requirements and the turning ability problems of the hovercrafts characterized by compact dimensions (with small width, powerful engine and big propellers). These vehicles require a very accurate control system, to combine the command of turning or trim with the possibility of reversing the thrust. In this article we briefly describe compact hovercrafts and focus on the various systems projected to improve their turning ability. We give an account of the steps which led to achieve our technical solutions and show the various systems of passive control surfaces adopted: to verify the different assessed implementations, several on-field tests have been performed on two vehicles, the Hover4 and the Multipurpose Air Cushion Platform (MACP). Finally we illustrate the ultimate chosen version of the system, in particular we outline the positive effects of the adoption of an unusual axis of rotation used to solve the problems created by the vertical rudders, whose centre is higher than the barycentre of the vehicle

Equivalent Circuit for RF Flexural Free-Free MEMS Resonators

A method to extract a lumped-parameter equivalent circuit for a free-free flexural MEMS resonator, based on the Euler-Bernoulli beam equation and exploiting a modal analysis approach, is presented. The dynamic behaviour predicted by the equivalent circuit is compared with FEM simulations, and the effect of a geometrical mismatch is investigated as well. The resonance frequency and the quality factor are correctly predicted. The method could be used for more complex systems of interconnected beams. The circuit can be used as a quick and intuitive analysis tool for the system-level designer and to allow the simulation of the device in a system-level design environment

Modeling and Characterization of Three Kinds of MEMS Resonators Fabricated with a Thick Polysilicon Technology

Three different kinds of two-port flexural resonators, with both clamped and free ends, and with nominal resonance frequencies between 5 MHz and 50 MHz, were designed and fabricated. Among them, a novel free-free third-mode resonator, as well as a tunable free-free resonator, designed to maintain a high quality factor despite its tunability, are presented. Because of reduced energy loss in the clamps, higher quality factors are expected from free-free devices. To estimate the resonators performance, the effect of temperature and axial stresses on the resonators is investigated: for the clamped-clamped resonator, a theoretical model is also presented. FEM simulations are performed for the three geometries and the results are discussed

Circumventing antivector immunity: potential use of nonhuman adenoviral vectors

Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed. Preexisting humoral and cellular immunity against common HAdV serotypes limits the efficacy of gene transfer and duration of transgene expression. As an alternative, nonhuman AdV (NHAdV) vectors can circumvent neutralizing antibodies against HAdVs in immunized mice and monkeys and in human sera, suggesting that NHAdV vectors could circumvent preexisting humoral immunity against HAdVs in a clinical setting. Consequently, there has been an increased interest in developing NHAdV vectors for gene delivery in humans. In this review, we outline the recent advances and limitations of HAdV vectors for gene therapy and describe examples of NHAdV vectors focusing on their immunogenicity, tropism, and potential as effective gene therapy vehicles

From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities