Walter Campbell:A distinguished life

An efficient and simple synthesis approach to form stable (68) Ga-labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self-assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well-defined spherical shape with a diameter of 290 +/- 50 nm. The radionuclide (68) Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these (68) Ga-nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging

The Properties of Field Elliptical Galaxies at Intermediate Redshift. I: Empirical Scaling Laws

We present measurements of the Fundamental Plane (FP) parameters (the effective radius, the mean effective surface brightness, and the central velocity dispersion) of six field elliptical galaxies at intermediate redshift. The imaging is taken from the Medium Deep Survey of the Hubble Space Telescope, while the kinematical data are obtained from long-slit spectroscopy using the 3.6-m ESO telescope. The Fundamental Plane appears well defined in the field even at redshift $\approx$ 0.3. The data show a shift in the FP zero point with respect to the local relation, possibly indicating modest evolution, consistent with the result found for intermediate redshift cluster samples. The FP slopes derived for our field data, plus other cluster ellipticals at intermediate redshift taken from the literature, differ from the local ones, but are still consistent with the interpretation of the FP as a result of homology, of the virial theorem and of the existence of a relation between luminosity and mass, $L \propto M^{\eta}$. We also derive the surface brightness vs. effective radius relation for nine galaxies with redshift up to $z \approx0.6$, and data from the literature; the evolution that can be inferred is consistent with what is found using the FP.Comment: 17 pages, including 9 figures, MNRAS, accepte

Energy Momentum Pseudo-Tensor of Relic Gravitational Wave in Expanding Universe

We study the energy-momentum pseudo-tensor of gravitational wave, and examine the one introduced by Landau-Lifshitz for a general gravitational field and the effective one recently used in literature. In short wavelength limit after Brill-Hartle average, both lead to the same gauge invariant stress tensor of gravitational wave. For relic gravitational waves in the expanding universe, we examine two forms of pressure, $p_{gw}$ and $\mathcal{P}_{gw}$, and trace the origin of their difference to a coupling between gravitational waves and the background matter. The difference is shown to be negligibly small for most of cosmic expansion stages starting from inflation. We demonstrate that the wave equation is equivalent to the energy conservation equation using the pressure $\mathcal{P}_{gw}$ that includes the mentioned coupling.Comment: 15 pages, no figure, Accepted by PR

Variations of Steroid Hormone Metabolites in Serum and Urine in Polycystic Ovary Syndrome after Nafarelin Stimulation: Evidence for an Altered Corticoid Excretion.

To evaluate the clinical relevance of testing pituitary-ovarian responses in patients suffering from polycystic ovary syndrome (PCOS) with the GnRH agonist nafarelin, a 1.2-mg dose of nafarelin was given intranasally to 19 women with PCOS and 15 healthy premenopausal women. The subsequent analysis of steroids in both serum and urine during the test was carried out at several time points for up to 24 h. Serum levels of 17 alpha-hydroxyprogesterone were elevated at all time points of the test in PCOS patients vs. controls [at baseline, 3.5 +/- 0.2 vs. 1.8 +/- 0.1 nmol/L (P < 0.001); at 24 h, 9.9 +/- 0.9 vs. 4.9 +/- 0.3 nmol/L (P < 0.001)]. Basal levels of androstenedione were higher in the patient group, but there was no significant change during the test in either group. Serum testosterone levels were also found to differ in PCOS patients compared with the control values at baseline (2.2 +/- 0.2 vs. 1.5 +/- 0.1 nmol/L; P < 0.05) and after nafarelin treatment (at 24 h, 3.2 +/- 0.4 vs. 1.8 +/- 0.2 nmol/L; P < 0.05). Serum estradiol levels rose significantly in both groups during the test; the posttest levels were significantly higher in PCOS than in controls. The PCOS patients displayed a significant increase in androgen and gestagen metabolites as well as in glucocorticoid metabolites excreted in the urine during the 24 h. In the control subjects, except for 17 alpha-hydroxypregnanolone, which rose significantly, none of the urinary steroids investigated showed relevant changes during the nafarelin test. The posttest excretion of allo-tetrahydrocortisol (1.4 +/- 0.2 vs. 0.3 +/- 0.1 mumol/g creatinine; P < 0.001) and the increase in 17 alpha-hydroxypregnanolone excretion (1.4 +/- 0.2 vs. 0.3 +/- 0.1 mumol/g creatinine; P < 0.001) were distinctly higher in PCOS patients than in the controls; the diagnostic sensitivity of the combination of both parameters was 89% at a 93% specificity. Thus, measurements of 17 alpha-hydroxyprogesterone levels in serum and of urinary allo-tetrahydrocortisol and 17 alpha-hydroxypregnanolone after nafarelin treatment make this stimulation test a valuable diagnostic tool for identifying PCOS patients. The significant changes in the excretion of urinary androgen and gestagen metabolites, unmasked by GnRH agonist stimulation, suggest a functional alteration of the pituitary-ovarian axis. The reason for the increased excretion of glucocorticoid metabolites after nafarelin stimulation remains to be clarified

Free energy landscape of siRNA-polycation complexation: Elucidating the effect of molecular geometry, polymer flexibility, and charge neutralization

The success of medical threatments with DNA and silencing interference RNA is strongly related to the design of efficient delivery technologies. Cationic polymers represent an attractive strategy to serve as nucleic-acid carriers with the envisioned advantages of efficient complexation, low cost, ease of production, well-defined size, and low polydispersity index. However, the balance between efficacy and toxicity (safety) of these polymers is a challenge and in need of improvement. With the aim of designing more effective polycationic-based gene carriers, many parameters such as carrier morphology, size, molecular weight, surface chemistry, and flexibility/rigidity ratio need to be taken into consideration. In the present work, the binding mechanism of three cationic polymers (polyarginine, polylysine and polyethyleneimine) to a model siRNA target is computationally investigated at the atomistic level. In order to better understand the polycationic carrier-siRNA interactions, replica exchange molecular dynamic simulations were carried out to provide an exhaustive exploration of all the possible binding sites, taking fully into account the siRNA flexibility together with the presence of explicit solvent and ions. Moreover, well-tempered metadynamics simulations were employed to elucidate how molecular geometry, polycation flexibility, and charge neutralization affect the siRNA-polycations free energy landscape in term of low-energy binding modes and unbinding free energy barriers. Significant differences among polymer binding modes have been detected, revealing the advantageous binding properties of polyarginine and polylysine compared to polyethyleneimine

Massive, Absorption-selected Galaxies at Intermediate Redshifts

The nature of absorption-selected galaxies and their connection to the general galaxy population have been open issues for more than three decades, with little information available on their gas properties. Here we show, using detections of carbon monoxide (CO) emission with the Atacama Large Millimeter/submillimeter Array (ALMA), that five of seven high-metallicity, absorption-selected galaxies at intermediate redshifts, $z \approx 0.5-0.8$, have large molecular gas masses, $M_{\rm Mol} \approx (0.6 - 8.2) \times 10^{10} \: {\rm M}_\odot$ and high molecular gas fractions ($f_{\rm Mol} \equiv \: M_{\rm Mol}/(M_\ast + M_{\rm Mol}) \approx 0.29-0.87)$. Their modest star formation rates (SFRs), $\approx (0.3-9.5) \: {\rm M}_\odot$ yr$^{-1}$, then imply long gas depletion timescales, $\approx (3 - 120)$ Gyr. The high-metallicity absorption-selected galaxies at $z \approx 0.5-0.8$ appear distinct from populations of star-forming galaxies at both $z \approx 1.3-2.5$, during the peak of star formation activity in the Universe, and lower redshifts, $z \lesssim 0.05$. Their relatively low SFRs, despite the large molecular gas reservoirs, may indicate a transition in the nature of star formation at intermediate redshifts, $z \approx 0.7$.Comment: 8 pages, 3 figures; accepted for publication in Astrophysical Journal Letters. Minor changes to match the version in press in ApJ

Mathisson's helical motions for a spinning particle --- are they unphysical?

It has been asserted in the literature that Mathisson's helical motions are unphysical, with the argument that their radius can be arbitrarily large. We revisit Mathisson's helical motions of a free spinning particle, and observe that such statement is unfounded. Their radius is finite and confined to the disk of centroids. We argue that the helical motions are perfectly valid and physically equivalent descriptions of the motion of a spinning body, the difference between them being the choice of the representative point of the particle, thus a gauge choice. We discuss the kinematical explanation of these motions, and we dynamically interpret them through the concept of hidden momentum. We also show that, contrary to previous claims, the frequency of the helical motions coincides, even in the relativistic limit, with the zitterbewegung frequency of the Dirac equation for the electron

NICMOS Snapshot Survey of Damped Lyman Alpha Quasars

We image 19 quasars with 22 damped Lyman alpha (DLA) systems using the F160W filter and the Near-Infrared Camera and Multiobject Spectrograph aboard the Hubble Space Telescope, in both direct and coronagraphic modes. We reach 5 sigma detection limits of ~H=22 in the majority of our images. We compare our observations to the observed Lyman-break population of high-redshift galaxies, as well as Bruzual & Charlot evolutionary models of present-day galaxies redshifted to the distances of the absorption systems. We predict H magnitudes for our DLAs, assuming they are producing stars like an L* Lyman-break galaxy (LBG) at their redshift. Comparing these predictions to our sensitivity, we find that we should be able to detect a galaxy around 0.5-1.0 L* (LBG) for most of our observations. We find only one new possible candidate, that near LBQS0010-0012. This scarcity of candidates leads us to the conclusion that most DLA systems are not drawn from a normal LBG luminosity function nor a local galaxy luminosity function placed at these high redshifts.Comment: 31 pages, 8 figures, Accepted for Feb. 10 issue of Ap