Four-quark flux distribution and binding in lattice SU(2)

The full spatial distribution of the color fields of two and four static quarks is measured in lattice SU(2) field theory at separations up to 1 fm at beta=2.4. The four-quark case is equivalent to a qbar q qbar q system in SU(2) and is relevant to meson-meson interactions. By subtracting two-body flux tubes from the four-quark distribution we isolate the flux contribution connected with the four-body binding energy. This contribution is further studied using a model for the binding energies. Lattice sum rules for two and four quarks are used to verify the results.Comment: 46 pages including 71 eps figures. 3D color figures are available at www.physics.helsinki.fi/~ppennane/pics

Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.

Acute viral pneumonia is an important cause of acute lung injury (ALI), although not enough is known about the exact incidence of viral infection in ALI. Polymerase chain reaction-based assays, direct fluorescent antigen (DFA) assays, and viral cultures can detect viruses in samples from the human respiratory tract, but the presence of the virus does not prove it to be a pathogen, nor does it give information regarding the interaction of viruses with the host immune response and bacterial flora of the respiratory tract. The severe acute respiratory syndrome (SARS) epidemic and the 2009 H1N1 influenza pandemic provided a better understanding of how viral pathogens mediate lung injury. Although the viruses initially infect the respiratory epithelium, the relative role of epithelial damage and endothelial dysfunction has not been well defined. The inflammatory host immune response to H1N1 infection is a major contributor to lung injury. The SARS coronavirus causes lung injury and inflammation in part through actions on the nonclassical renin angiotensin pathway. The lessons learned from the pandemic outbreaks of SARS coronavirus and H1N1 capture key principles of virally mediated ALI. There are pathogen-specific pathways underlying virally mediated ALI that converge onto a common end pathway resulting in diffuse alveolar damage. In terms of therapy, lung protective ventilation is the cornerstone of supportive care. There is little evidence that corticosteroids are beneficial, and they might be harmful. Future therapeutic strategies may be targeted to specific pathogens, the pathogenetic pathways in the host immune response, or enhancing repair and regeneration of tissue damage

Room-temperature superparamagnetism due to giant magnetic anisotropy in MoS_{S} defected single-layer MoS2_{2}

Room-temperature superparamagnetism due to a large magnetic anisotropy energy (MAE) of a single atom magnet has always been a prerequisite for nanoscale magnetic devices. Realization of two dimensional (2D) materials such as single-layer (SL) MoS$_{2}$, has provided new platforms for exploring magnetic effects, which is important for both fundamental research and for industrial applications. Here, we use density functional theory (DFT) to show that the antisite defect (Mo$_{S}$) in SL MoS$_{2}$ is magnetic in nature with a magnetic moment of $\mu$ of $\sim$ 2$\mu_{B}$ and, remarkably, exhibits an exceptionally large atomic scale MAE$=\varepsilon_{\parallel}-\varepsilon_{\perp}$ of $\sim$500 meV. Our calculations reveal that this giant anisotropy is the joint effect of strong crystal field and significant spin-orbit coupling (SOC). In addition, the magnetic moment $\mu$ can be tuned between 1$\mu_{B}$ and 3$\mu_{B}$ by varying the Fermi energy $\varepsilon_{F}$, which can be achieved either by changing the gate voltage or by chemical doping. We also show that MAE can be raised to $\sim$1 eV with n-type doping of the MoS$_{2}$:Mo$_{S}$ sample. Our systematic investigations deepen our understanding of spin-related phenomena in SL MoS$_{2}$ and could provide a route to nanoscale spintronic devices.Comment: 7 pages, 7 figure

Level discrimination of speech sounds by hearing-impaired individuals with and without hearing amplification

Objectives: The current study was designed to see how hearing-impaired individuals judge level differences between speech sounds with and without hearing amplification. It was hypothesized that hearing aid compression should adversely affect the user's ability to judge level differences. Design: Thirty-eight hearing-impaired participants performed an adaptive tracking procedure to determine their level-discrimination thresholds for different word and sentence tokens, as well as speech-spectrum noise, with and without their hearing aids. Eight normal-hearing participants performed the same task for comparison. Results: Level discrimination for different word and sentence tokens was more difficult than the discrimination of stationary noises. Word level discrimination was significantly more difficult than sentence level discrimination. There were no significant differences, however, between mean performance with and without hearing aids and no correlations between performance and various hearing aid measurements. Conclusions: There is a clear difficulty in judging the level differences between words or sentences relative to differences between broadband noises, but this difficulty was found for both hearing-impaired and normal-hearing individuals and had no relation to hearing aid compression measures. The lack of a clear adverse effect of hearing aid compression on level discrimination is suggested to be due to the low effective compression ratios of currently fit hearing aids

Alabama: Round 1 - State-Level Field Network Study of the Implementation of the Affordable Care Act

This report is part of a series of 21 state and regional studies examining the rollout of the ACA. The national network -- with 36 states and 61 researchers -- is led by the Rockefeller Institute of Government, the public policy research arm of the State University of New York, the Brookings Institution, and the Fels Institute of Government at the University of Pennsylvania.More than 670,000 Alabamians under age sixty-five, or about 16 percent of the population, are uninsured. Most uninsured Alabamians are in working families (77 percent) where at least one person is employed either full time or part time. The largest total number and percentage of uninsured is aged nineteen to thirty and the uninsured are disproportionately people of color, although whites make up the majority of the uninsured population. The state insurance market is dominated by Blue Cross Blue Shield of Alabama (BCBSAL). In 2010, it had a 91 percent market share in the individual market with some 121,000 covered lives

Quantifying the Contours of Power: Chief Justice Roberts & Justice Kennedy in Criminal Justice Cases

This Article seeks to contribute to the debate with an empirical analysis of voting behavior in criminal justice cases decided during the first ten Terms of the Roberts Court era. The following section presents the study’s case selection and introduces the types of measures used to illuminate influence on the High Court (Part II). Court- and individual-level tendencies (Part III) identify potential spheres of influence occupied by Chief Justice Roberts and Justice Kennedy. These bases of judicial power are examined separately in Part IV (Chief Justice Roberts) and Part V (Justice Kennedy). Some possible implications of Justice Scalia’s death on these power bases are addressed in Part VI

Regulatory motif discovery using a population clustering evolutionary algorithm

This paper describes a novel evolutionary algorithm for regulatory motif discovery in DNA promoter sequences. The algorithm uses data clustering to logically distribute the evolving population across the search space. Mating then takes place within local regions of the population, promoting overall solution diversity and encouraging discovery of multiple solutions. Experiments using synthetic data sets have demonstrated the algorithm's capacity to find position frequency matrix models of known regulatory motifs in relatively long promoter sequences. These experiments have also shown the algorithm's ability to maintain diversity during search and discover multiple motifs within a single population. The utility of the algorithm for discovering motifs in real biological data is demonstrated by its ability to find meaningful motifs within muscle-specific regulatory sequences

Ab initio energies of nonconducting crystals by systematic fragmentation

A systematic method for approximating the ab initio electronic energy of molecules from the energies of molecular fragments has been adapted to estimate the total electronic energy of crystal lattices. The fragmentation method can be employed with any ab initio electronic structure method and allows optimization of the crystal structure based on ab initio gradients. The method is demonstrated on SiO₂ polymorphs using the Hartree-Fock approximation, second order Moller-Plesset perturbation theory, and the quadratic configuration interaction method with single and double excitations and triple excitations added perturbatively