Maps of zeroes of the grand canonical partition function in a statistical model of high energy collisions

Theorems on zeroes of the truncated generating function in the complex plane are reviewed. When examined in the framework of a statistical model of high energy collisions based on the negative binomial (Pascal) multiplicity distribution, these results lead to maps of zeroes of the grand canonical partition function which allow to interpret in a novel way different classes of events in pp collisions at LHC c.m. energies.Comment: 17 pages, figures (ps included); added references, some figures enlarged. To appear in J. Phys.

Automated Generation of Executable RPA Scripts from User Interface Logs

Robotic Process Automation (RPA) operates on the user interface (UI) of software applications and automates - by means of a software (SW) robot - mouse and keyboard interactions to remove intensive routine tasks (or simply routines). With the recent advances in Artificial Intelligence, the automation of routines is expected to undergo a radical transformation. Nonetheless, to date, the RPA tools available in the market are not able to automatically learn to automate such routines, thus requiring the support of skilled human experts that observe and interpret how routines are executed on the UIs of the applications. Being the current practice time-consuming and error-prone, in this paper we present SmartRPA, a cross-platform tool that tackles such issues by exploiting UI logs to automatically generate executable RPA scripts that automate the routines enactment by SW robots

Clan Properties in Parton Showers

By considering clans as genuine elementary subprocesses, i.e., intermediate parton sources in the Simplified Parton Shower model, a generalized version of this model is defined. It predicts analytically clan properties at parton level in agreement with the general trends observed experimentally at hadronic level and in Monte Carlo simulations both at partonic and hadronic level. In particular the model shows a linear rising in rapidity of the average number of clans at fixed energy of the initial parton and its subsequent bending for rapidity intervals at the border of phase space, and approximate energy independence of the average number of clans in fixed rapidity intervals. The energy independence becomes stricter by properly normalizing the average number of clans.Comment: (27 pages in Plain TeX plus 10 Postscript Figures, all compressed via uufiles) DFTT 7/9

In silico food-drug interaction: A case study of eluxadoline and fatty meal

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In this study, a computational protocol was proposed to explain the different assimilations of two µ-receptors agonists, eluxadoline and loperamide, with a peculiar pharmacokinetic profile. Compared to loperamide, eluxadoline is absorbed less after the intake of a fatty meal, and the LogP values do not explain this event. Firstly, keeping in mind the different pH in the intestinal tract, the protonation states of both compounds were calculated. Then, all structures were subjected to a conformational search by using MonteCarlo and Molecular Dynamics methods, with solvation terms mimicking the water and weak polar solvent (octanol). Both computational results showed that eluxadoline has less conformational freedom in octanol, unlike loperamide, which exhibits constant behavior in both solvents. Therefore, we hypothesize that fatty meal causes the “closure” of the eluxadoline molecule to prevent the exposure of the polar groups and their interaction with water, necessary for the drug absorption. Based on our results, this work could be a reasonable “case study”, useful for future investigation of the drug pharmacokinetic profile

Evolution of average multiplicities of quark and gluon jets

The energy evolution of average multiplicities of quark and gluon jets is studied in perturbative QCD. Higher order (3NLO) terms in the perturbative expansion of equations for the generating functions are found. First and second derivatives of average multiplicities are calculated. The mean multiplicity of gluon jets is larger than that of quark jets and evolves more rapidly with energy. It is shown which quantities are most sensitive to higher order perturbative and nonperturbative corrections. We define the energy regions where the corrections to different quantities are important. The latest experimental data are discussed.Comment: 23 pages including 3 figures. Version 2 contains small correction to equation (41

QCD explanation of oscillating hadron and jet multiplicity moments

Ratios of multiplicity moments, H_q (cumulant over factorial moments K_q/F_q), have been observed to show an oscillatory behaviour with respect to order, q. Recent studies of e^+e^- annihilations at LEP have shown, moreover, that the amplitude and oscillation length vary strongly with the jet resolution parameter y_{cut}. We study the predictions of the perturbative QCD parton cascade assuming low non-perturbative cut-off (Q_0\sim \Lambda_{QCD}\sim few 100 MeV) and derive the expectations as a function of the cms energy and jet resolution from threshold to very high energies. We consider numerical solutions of the evolution equations of gluodynamics in Double Logarithmic and Modified Leading Logarithmic Approximations (DLA,MLLA), as well as results from a parton MC with readjusted parameters. The main characteristics are obtained in MLLA, while a more numerically accurate description is obtained by the MC model. A unified description of correlations between hadrons and correlations between jets emerges, in particular for the transition region of small y_{cut}.Comment: 31 pages, 14 figure

Clan Structure Analysis and Rapidity Gap Probability

Clan structure analysis in rapidity intervals is generalized from negative binomial multiplicity distribution to the wide class of compound Poisson distributions. The link of generalized clan structure analysis with correlation functions is also established. These theoretical results are then applied to minimum bias events and evidentiate new interesting features, which can be inspiring and useful in order to discuss data on rapidity gap probability at TEVATRON and HERA.Comment: (14 pages in Plain TeX plus 5 Postscript Figures, all compressed via uufiles) DFTT 28/9

QCD and hybrid NBD on oscillating moments of multiplicity distributions in lepton- and hadron-initiated reactions

QCD predictions for moments of multiplicity distributions are compared with experimental data on e+e- collisions and their two-NBD fits. Moments of the multiplicity distribution in a two-NBD model for 1.8 TeV pp collisions are considered. Three-NBD model predictions and fits for pp at LHC energies are also discussed. Analytic expressions for moments of hybrid NBD are derived and used to get insight into jet parameters and multicomponent structure of the processes. Interpretation of observed correlations is proposed.Comment: 8 pages, no figures, Phys. Lett.

Incessant pericarditis as a risk factor for complicated pericarditis and hospital admission

Abstract Background Incessant pericarditis is defined as pericarditis with persistent symptoms without a symptom-free interval of 4 to 6 weeks despite therapy. On the contrary, recurrent pericarditis is characterized by recurring symptoms after a symptom-free interval of at least 4 to 6 weeks, allowing the completion of therapy. Aims The aim of this study is to assess the risk of complicated pericarditis and related hospitalizations according to the clinical pattern of incessant or recurrent pericarditis. Methods From January 2017 to December 2018, all consecutive patients admitted to AOU Città della Salute (Turin, IT) for pericarditis were included in a prospective cohort study with a clinical and echocardiographic follow-up at 1, 3, and 6 months, and then every 6 months. Results We included 147 patients (median age, 50.9 years [IQR, 28.5]; 49.7% women, 89% had idiopathic aetiology, 11% had pericarditis related to systemic inflammatory disease/postcardiac injury syndrome, 80% had pericardial effusion, and 62% had elevated C-reactive protein >5 mg/L). Patients were treated according to ESC guidelines. After a median follow-up of 14 months (IQR, 9 months), adverse events were recorded in 54/147 patients (36.7%): nonidiopathic/viral aetiology in 16 of 147 cases (10.9%), recurrent pericarditis/persistent symptoms in 53 of 147 cases (36.1%), cardiac tamponade in 4/147 cases (2.7%), persistent CP in 4/147 cases (2.7%), and hospitalization related to pericarditis in 38/147 cases (25.9%). An incessant course was reported in 18 of 147 cases (12%). The risk of complications was higher in patients with incessant pericarditis (Figure) – especially CP – compared to nonincessant course (22.2% versus 0%, respectively; P<0.001). Patients with incessant pericarditis more commonly had echocardiographic evidence of CP (77.8% vs. 9.3%; P<0.001) and thickened pericardium on multimodality imaging (66.7% vs. 4.7%; P<0.001). These findings were reversible with medical therapy with the use of anakinra (100 mg/d) and colchicine in all but 4 cases that progressed to persistent CP, which were referred for pericardiectomy. An analysis of risk factors for complicated pericarditis and hospitalization using Cox proportional hazards regression analysis identified the following risk factors: large pericardial effusion (hazard ratio, 7.63 [95% CI, 3.09–18.83]), elevated C-reactive protein >5 mg/L (hazard ratio, 5.55 [95% CI, 1.87–16.44]), and incessant course (HR, 17.10 [95% CI, 7.63–38.33]). Conclusions This study highlights that an incessant course of pericarditis is a possible new risk factor for complications and especially for developing constriction. In clinical practice, the detection of an incessant course, as well as imaging findings of constriction and pericardial thickening, should prompt more diagnostic testing, a close follow-up, and more aggressive therapy to prevent complications and persistent constriction. Funding Acknowledgement Type of funding sources: None. Figure