Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of DPYD and fluoropyrimidines

Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of three anti-cancer drugs (fluoropyrimidines: 5-fluorouracil, capecitabine and tegafur) to decrease the risk of severe, potentially fatal, toxicity (such as diarrhoea, hand-foot syndrome, mucositis or myelosuppression). Dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene) enzyme deficiency increases risk of fluoropyrimidine-induced toxicity. The DPYD-gene activity score, determined by four DPYD variants, predicts DPD activity and can be used to optimize an individual's starting dose. The gene activity score ranges from 0 (no DPD activity) to 2 (normal DPD activity). In case it is not possible to calculate the gene activity score based on DPYD genotype, we recommend to determine the DPD activity and adjust the initial dose based on available data. For patients initiating 5-fluorouracil or capecitabine: subjects with a gene activity score of 0 are recommended to avoid systemic and cutaneous 5-fluorouracil or capecitabine; subjects with a gene activity score of 1 or 1.5 are recommended to initiate therapy with 50% the standard dose of 5-fluorouracil or capecitabine. For subjects initiating tegafur: subjects with a gene activity score of 0, 1 or 1.5 are recommended to avoid tegafur. Subjects with a gene activity score of 2 (reference) should receive a standard dose. Based on the DPWG clinical implication score, DPYD genotyping is considered "essential", therefore directing DPYD testing prior to initiating fluoropyrimidines

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines

Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of three anti-cancer drugs (fluoropyrimidines: 5-fluorouracil, capecitabine and tegafur) to decrease the risk of severe, potentially fatal, toxicity (such as diarrhoea, hand-foot syndrome, mucositis or myelosuppression). Dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene) enzyme deficiency increases risk of fluoropyrimidine-induced toxicity. The DPYD-gene activity score, determined by four DPYD variants, predicts DPD activity and can be used to optimize an individual’s starting dose. The gene activity score ranges from 0 (no DPD activity) to 2 (normal DPD activity). In case it is not possible to calculate the gene activity score based on DPYD genotype, we recommend to determine the DPD activity and adjust the initial dose based on available data. For patients initiating 5-fluorouracil or capecitabine: subjects with a gene activity score of 0 are recommended to avoid systemic and cutaneous 5-fluorouracil or capecitabine; subjects with a gene activity score of 1 or 1.5 are recommended to initiate therap

Changes in quality of life into adulthood after very preterm birth and/or very low birth weight in the Netherlands

It is important to know the impact of Very Preterm (VP) birth or Very Low Birth Weight (VLBW). The purpose of this study is to evaluate changes in Health-Related Quality of Life (HRQoL) of adults born VP or with a VLBW, between age 19 and age 28. Methods The 1983 nationwide Dutch Project On Preterm and Small for gestational age infants (POPS) cohort of 1338 VP (gestational age <32 weeks) or VLBW (<1500 g) infants, was contacted to complete online questionnaires at age 28. In total, 33.8% of eligible participants completed the Health Utilities Index (HUI3), the London Handicap Scale (LHS) and the WHOQoL-BREF. Multiple imputation was applied to correct for missing data and non-response. Results The mean HUI3 and LHS scores did not change significantly from age 19 to age 28. However, after multiple imputation, a significant, though not clinically relevant, increase of 0.02 on the overall HUI3 score was found. The mean HRQoL score measured with the HUI3 increased from 0.83 at age 19 to 0.85 at age 28. The lowest score on the WHOQoL was the psychological domain (74.4). Conclusions Overall, no important changes in HRQoL between age 19 and age 28 were found in the POPS cohort. Psychological and emotional problems stand out, from which recommendation for interventions could be derived

[Monitoring van radioactiviteit in de atmosfeer en een voedselketen. Resultaten in Nederland 1992.]

This 1992 annual report presents the results of biosphere sample measurements by the Laboratory of Radiation Research (LSO) of the National Institute of Public Health and Environmental Protection (RIVM). The measurements are part of the National Measurement Programme (NMP) of the Coordinating Committee for the Monitoring of Radioactive and Xenobiotic Substances (CCRX) in the Netherlands. The NMP is considered essential for an adequate assessment of radioactivity in the biosphere. The programme of the RIVM/LSO includes samples of airdust and deposition taken at the RIVM premises in Bilthoven. Contrary to previous years measurements of radioactivity concentrations in surface- and sea water samples were not performed. Samples of grass and milk were taken from the surroundings of nuclear installations in the Netherlands and on Dutch territory in the vicinity of such installations situated abroad. An overall country milk sample from four milk factories in the Netherlands was also analysed. This report also presents information concerning the operationality and the data of the National Radioactivity Monitoring Network (LMR) in 1992. These data are not included in the NMP. In 1992, the yearly average gross alpha-and gross beta-activity concentration of airdust was 0.06 +- 0.01 and 0.44 +- 0.06 mBq.m-3, respectively. These values were significantly higher than those of previous years. This effect is explained by a change in the procedures for sample taking and sample treatment. The aerosol monitors of the LMR had an average availability of 88% in 1992, which is an improvement over the value of 76% in 1991. In 1992, just as in previous years, some structural monitor failures reduced the availability. The proportional counters were almost free of failures ; the average monitor availability was 96%, which is also an improvement compared to the 92% of the year before.HIMHVH

Integrale rapportage 1994

In dit jaarverslag over 1994 zijn de resultaten weergegeven van de metingen van radioactiviteit in milieumonsters uitgevoerd door het Laboratorium voor Stralingsonderzoek (LSO) van het Rijksinstituut voor Volksgezondheid en Milieu. De metingen maken deel uit van het Nationaal Meetprogramma (NMP) in Nederland. Het betreft metingen die geacht worden essentieel te zijn voor een doelmatige controle van radioactieve besmetting in het milieu. De analyses worden uitgevoerd in monsters luchtstof, depositie, gras en melk. Monsters van gras en melk zijn genomen in de omgeving van Nederlandse kerncentrales en op Nederlands grondgebied in de omgeving van kerncentrales in het buitenland. Ook zijn melkmonsters van vier melkfabrieken, verspreid over het land, geanalyseerd. In dit rapport worden tevens de resultaten van het Landelijk Meetnet voor Radioactiviteit (LMR) besproken. Deze metingen zijn geen onderdeel van het NMP.This 1994 annual report presents the results of radiation measurements by the Laboratory of Radiation Research (LSO) of the National Institute of Public Health and the Environment (RIVM). The measurements are part of the National Measurement Programme (NMP) of the Coordinating Committee for the Monitoring of Radioactive and Xenobiotic Substances (CCRX) in the Netherlands. The NMP is considered essential for an adequate assessment of radioactivity in the biosphere. The programme of the RIVM/LSO includes samples of airdust and deposition taken at the RIVM premises in Bilthoven. Samples of grass and milk were taken from the surroundings of nuclear installations in the Netherlands and on Dutch territory in the vicinity of such installations situated abroad. An overall country milk sample from four milk factories in the Netherlands was analyzed as well. This report also presents the data of the National Radioactivity Monitoring Network (LMR) in 1994. These data are not included in the NMP.HIMHVH

Milieurapportage 1993. IV. Monitoring of radiation in the atmosphere and a food chain. Results in the Netherlands in 1992

This 1992 annual report presents the results of biosphere sample measurements by the Laboratory of Radiation Research (LSO) of the National Institute of Public Health and Environmental Protection (RIVM). The measurements are part of the National Measurement Programme (NMP) of the Coordinating Committee for the Monitoring of Radioactive and Xenobiotic Substances (CCRX) in the Netherlands. The NMP is considered essential for an adequate assessment of radioactivity in the biosphere. The programme of the RIVM/LSO includes samples of airdust and deposition taken at the RIVM premises in Bilthoven. Contrary to previous years measurements of radioactivity concentrations in surface- and sea water samples were not performed. Samples of grass and milk were taken from the surroundings of nuclear installations in the Netherlands and on Dutch territory in the vicinity of such installations situated abroad. An overall country milk sample from four milk factories in the Netherlands was also analysed. This report also presents information concerning the operationality and the data of the National Radioactivity Monitoring Network (LMR) in 1992. These data are not included in the NMP. In 1992, the yearly average gross alpha-and gross beta-activity concentration of airdust was 0.06 +- 0.01 and 0.44 +- 0.06 mBq.m-3, respectively. These values were significantly higher than those of previous years. This effect is explained by a change in the procedures for sample taking and sample treatment. The aerosol monitors of the LMR had an average availability of 88% in 1992, which is an improvement over the value of 76% in 1991. In 1992, just as in previous years, some structural monitor failures reduced the availability. The proportional counters were almost free of failures ; the average monitor availability was 96%, which is also an improvement compared to the 92% of the year before.<br

Sharing open hardware through ROP, the robotic open platform

The robot open source software community, in particular ROS, drastically boosted robotics research. However, a centralized place to exchange open hardware designs does not exist. Therefore we launched the Robotic Open Platform (ROP). A place to share and discuss open hardware designs. Among others it currently contains detailed descriptions of Willow Garage's TurtleBot, the NimbRo-OP created by the University of Bonn and the AMIGO robot of Tech United Eindhoven. Eventually, ROP will contain a collection of affordable hardware components, allowing researchers to focus on cutting-edge research on a particular component instead of having to design the entire robot from scratch. As an example of how the Robotic Open Platform is able to facilitate this knowledge transfer, we introduce TURTLE-5k: A redesign of an existing soccer robot by a consortium of our university and companies in the wider Eindhoven area. Cooperating with industrial partners resulted in a significant cost reduction

Tech United Eindhoven @Home 2019 champions paper

\u3cp\u3eThis paper provides an overview of the main developments of the Tech United Eindhoven RoboCup @Home team. Tech United uses an advanced world modeling system called the Environment Descriptor. It allows straightforward implementation of localization, navigation, exploration, object detection &amp; recognition, object manipulation and robot-robot cooperation skills based on the most recent state of the world. Other important features include object and people detection via deep learning methods, a GUI, speech recognition, natural language interpretation and a chat interface combined with a conversation engine. Recent developments that aided with obtaining the victory during RoboCup 2019 include pointing detection, usage of HSR’s display, a people detector and the addition of a custom keyboard in the chat interface.\u3c/p\u3