Casting and Mechanized Titanium Restorations

INTRODUCTION: New materials and methods for clinical dentistry are continuously being introduced. There is a growing interest in the use of titanium as a restorative material for several reasons: its relatively low cost, favorable physical properties and biocompatibility. However, titanium is technically more difficult to handle than conventional metal alloys. There are two fabrication methods for titanium restorations: casting and mechanized (a combination of machine duplication and spark erosion-Pro- -cera method). PURPOSE: The aim of this review was to evaluate the advantages and disadvantages of the two fabrication methods used for titanium restorations and to make some recommendations on the indications. MATERIAL AND METHODS: Dental literature was reviewed including clinical and technique articles on the use of titanium in prosthodontic restorations. RESULT: The use of mechanized titanium has more restrictive indications than casting, but assures better marginal fit of the restorations. The bond strength of porcelain fused to titanium is questioned, because of the lower rigidity of titanium than conventional alloys and discrepancies in the thermal expansion coefficient between titanium and ceramic. Thus, low fusing ceramics tend to predominate today. The esthetic result varies. Furthermore titanium restorations require a qualified dental technician. CONCLUSION: It can be concluded that titanium is a promising alternative for prosthodontic restorations. Several error sources associated with casting can be eliminated with mechanized titanium restorations. However, little information is availableon the clinical performance of titanium restorations. More clinical prospective studies are necessary before titanium can be recommended for general clinical use

Levels of Sustainability Awareness in Spanish University Students of Nautical Activities as Future Managers of Sports and Active Tourism Programmes

© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Abstract: University students will play an important role in making decisions that will affect the environment, as future leaders of our society. Their level of sensitivity and environmental knowledge will play an important role in adequately facing future challenges. This article aims to measure the sustainability awareness of a sample of future graduates in Physical Activity and Sport Sciences in Spain. The literature supports that the sensitivity of these students can be estimated by using the Spanish adaptation of the SCQ-S. This allows for establishing the level of knowledge, attitudes and behaviour pertaining to sustainability in three dimensions: environmental, social and economic. The sample consisted of 170 students (58.8% males; 41.2% females) with a mean age of 20.5 years (±4.039). The overall Cronbach’s alpha showed a fairly good value (α = 0.836). The same was true for the Kaiser–Meyer–Olkin test values (KMO = 0.816) and Bartlett’s sphericity test (p < 0.001). The knowledge construct (4.56 ± 0.53) was the highest descriptive, followed by attitude (4.12 ± 0.59). The lowest value was behaviour (3.79 ± 0.66). By gender, girls obtained the highest sensitivity indexes. In addition, the place of habitual residence and physical activity in the natural environment were related to the overall behaviour of the university students. It is concluded that being in active contact with the natural environment allows us to have a higher level of awareness

Enhancement of metabolite production in high-altitude microalgal strains by optimized C/N/P ratio

This study evaluated the role of C/N/P in the increase in the synthesis of carbohydrates, proteins, and lipids in two high-mountain strains of algae (Chlorella sp. UFPS019 and Desmodesmus sp. UFPS021). Three carbon sources (sodium acetate, sodium carbonate, and sodium bicarbonate), and the sources of nitrogen (NaNO3) and phosphate (KH2PO4 and K2HPO4) were analyzed using a surface response (3 factors, 2 levels). In Chlorella sp. UFPS019, the optimal conditions to enhance the synthesis of carbohydrates were high sodium carbonate content (3.53 g/L), high KH2PO4 and K2HPO4 content (0.06 and 0.14 g/L, respectively), and medium-high NaNO3 (0.1875 g/L). In the case of lipids, a high concentration of sodium acetate (1.19 g/L) coupled with high KH2PO4 and K2HPO4 content (0.056 and 0.131 g/L, respectively) and a low concentration of NaNO3 (0.075 g/L) drastically induced the synthesis of lipids. In the case of Desmodesmus sp. UFPS021, the protein content was increased using high sodium acetate (2 g/L), high KH2PO4 and K2HPO4 content (0.056 and 0.131 g/L, respectively), and high NaNO3 concentration (0.25 g/L). These results demonstrate that the correct adjustment of the C/N/P ratio can enhance the capacity of high-mountain strains of algae to produce high concentrations of carbohydrates, proteins, and lipids

A Systematic Review of Clinical Practice Guidelines for Cancer Screening in Patients with Autoimmune Diseases

https://openworks.mdanderson.org/sumexp23/1110/thumbnail.jp

Rapid Phenotype-Driven Gene Sequencing with the NeoSeq Panel: A Diagnostic Tool for Critically Ill Newborns with Suspected Genetic Disease

New genomic sequencing techniques have shown considerable promise in the field of neonatology, increasing the diagnostic rate and reducing time to diagnosis. However, several obstacles have hindered the incorporation of this technology into routine clinical practice. We prospectively evaluated the diagnostic rate and diagnostic turnaround time achieved in newborns with suspected genetic diseases using a rapid phenotype-driven gene panel (NeoSeq) containing 1870 genes implicated in congenital malformations and neurological and metabolic disorders of early onset (<2 months of age). Of the 33 newborns recruited, a genomic diagnosis was established for 13 (39.4%) patients (median diagnostic turnaround time, 7.5 days), resulting in clinical management changes in 10 (76.9%) patients. An analysis of 12 previous prospective massive sequencing studies (whole genome (WGS), whole exome (WES), and clinical exome (CES) sequencing) in newborns admitted to neonatal intensive care units (NICUs) with suspected genetic disorders revealed a comparable median diagnostic rate (37.2%), but a higher median diagnostic turnaround time (22.3 days) than that obtained with NeoSeq. Our phenotype-driven gene panel, which is specific for genetic diseases in critically ill newborns is an affordable alternative to WGS and WES that offers comparable diagnostic efficacy, supporting its implementation as a first-tier genetic test in NICUs

A simulation analysis of an influenza vaccine production plant in areas of high humanitarian flow. A preliminary study for the region of norte de santander (colombia)

The production of vaccines of biological origin presents a tremendous challenge for re-searchers. In this context, animal cell cultures are an excellent alternative for the isolation and production of biologicals against several viruses, since they have an affinity with viruses and a great capacity for their replicability. Different variables have been studied to know the system’s ideal parameters, allowing it to obtain profitable and competitive products. Consequently, this work fo-cuses its efforts on evaluating an alternative for producing an anti‐influenza biological from MDCK cells using SuperPro Designer v8.0 software. The process uses the DMEN culture medium supple-mented with nutrients as raw material for cell development; the MDCK cells were obtained from a potential scale‐up with a final working volume of 500 L, four days of residence time, inoculum volume of 10%, and continuous working mode with up to a total of 7400 h/Yr of work. The scheme has the necessary equipment for the vaccine’s production, infection, and manufacture with yields of up to 416,698 units/h. In addition, it was estimated to be economically viable to produce recom-binant vaccines with competitive prices of up to 0.31 USD/unit

Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in 1759 X-rays: report of the OARSI–OMERACT task force

OBJECTIVE: The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods of knee osteoarthritis (OA), both on semiflexed and extended views. METHODS: In data obtained from trials and cohorts, X-rays were graded using Kellgren and Lawrence (KL), the OA Research Society International (OARSI) joint space narrowing score, and measurement of joint space width (JSW). JSW was analyzed as a categorical variable. Construct validity was assessed through logistic regression between X-ray stages and Western Ontario and McMaster Universities OA Index. Inter-observer reliability was assessed in 50 subjects for extended views by weighted kappa. Intra-observer reliability and sensitivity to change were assessed separately for extended and semiflexed views in 50 patients who had both views performed, over a 30-month interval, by weighted kappa and standardized response mean (SRM). RESULTS: Extended views were available from three trials and two cohorts (1759 X-rays), including one trial in which both extended and semiflexed views (antero-posterior) were obtained. Correlation with clinical parameters was low for the three scoring methods, except for the single community-based cohort. Inter-rater reliability was higher for categorical JSW in extended views (kappa, 0.86 vs 0.56 and 0.48 for KL and OARSI, respectively). Intra-rater reliability was higher for categorical JSW, both in extended views (0.83 vs 0.61 and 0.71) and in semiflexed views (0.89 vs 0.50 and 0.67). Sensitivity to change was also higher for categorical JSW, particularly in semiflexed views (SRM, 0.49 vs 0.22 and 0.34). CONCLUSION: These results indicate categorical JSW, in particular on semiflexed views, may be the preferred method to evaluate structural severity in knee OA clinical trials

Application of Chlorella sp. and Scenedesmus sp. in the bioconversion of urban leachates into industrially relevant metabolites

This paper explores the ability of Chlorella sp. and Scenedesmus sp. to convert landfill leachates into usable metabolites. Different concentrations (0.5, 1, 5, and 10% v/v) of leachate coupled with an inorganic carbon source (Na2CO3, and NaHCO3) were tested to improve biomass production, metabolites synthesis, and removal of NO3 and PO4 . The result shows that both strains can effectively grow in media with up to 5% (v/v) leachate, while significantly reducing the concentrations of NO3, and PO4 (80 and 50%, respectively). The addition of NaHCO3 as a carbon source improved the final concentration of biomass, lipids, carbohydrates, and the removal of NO3 and PO4 in both strains

REPORTE DEL PRIMER CASO DE RINOSPORIDIOSIS EN LA PROVINCIA CIEGO DE AVILA (CUBA)

Se presenta el primer caso de rinosporidiosis diangosticado en la provincia de Ciego de Avila, Cuba, analizándose las características clínico-epidemiológicas del caso. Paciente de 13 años de edad, de sexo masculino, proveniente de un area rural que presentaba localizacion nasal de las lesiones: Se revisa la literatura al respecto.

The effect of LEDs on biomass and phycobiliproteins production in thermotolerant oscillatoria sp

Featured Application: The selection of LEDs wavelength, intensity, and light: Dark cycle positively enhances the biomass production and phycocyanin synthesis in Oscillatoria sp. This study evaluates the role of different LED lights (white, blue/red), intensity (µmol m−2 s−1), and photoperiod in the production of biomass and phycocyanin-C, allophycocyanin and phycoerythrin (C-PC, APC, and PE respectively) from a novel thermotolerant strain of Oscillatoria sp. Results show that a mixture of white with blue/red LEDs can effectively double the biomass concentration up to 1.3 g/L, while the concentration of the selected phycobiliproteins increased proportionally to biomass. Results also indicate that high light intensities (&gt;120 µmol m−2 s−1) can diminish the final concentration of C-PC, APC, and PE, significantly reducing the overall biomass produced. Finally, the photoperiod analysis showed that longer light exposure times (18:6 h) improved both biomass and phycobiliproteins concentration. These results demonstrate that the application of LEDs to produce a novel strain of Oscillatoria sp can double the biomass concentration, and the photoperiod regulation can eventually enhance the final concentration of specific phycobiliproteins such as APC and PE