Peculiarities of gamma-quanta distribution at 20 TeV energy

The angular distribution of protons from the fragmentational region is analyzed. The gamma-quanta families are generated in a dense target by cosmic ray particles at 20 Tev energy. Families were found which had dense groups (spikes) of gamma-quanta where the rapidity/density is 3 times more than the average value determined for all registered families. The experimental data is compared with the results of artificial families simulation

Pharmacological efficiency of statins and L-norvalin at an endotoxin-induced endothelial dysfunction

In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out functional tests, increase of coefficient of endothelial dysfunction, decrease in contractility of a myocardium, activation processes of peroxidation of lipids and decreased activity of antioxidant systems, level of stable metabolites of nitrogen oxid

Pharmacological correction of metabolic disorders in experimental acute pancreatitis on the background of chronic alcohol intoxication

Objective to determine the specific features of immunometabolic changes in acute pancreatitis in the context of short-term and chronic alcohol intoxication and to develop the ways of pharmacological correction of the detected violation

РОЛЬ МАЛОГО И СРЕДНЕГО ИННОВАЦИОННОГО БИЗНЕСА В ЭКОНОМИЧЕСКОМ РАЗВИТИИ СТРАНЫ

This article features factors that have an eff ect on the country in the world’s economy. After it explains these factors, it determines the role and value of innovation in the modern world. It then determines the role of small and medium businesses in the country’s economy. While featuring the subject, it provides the characteristics of ventures companies, as well as their role and prospects in the country’s economy. The object of this research is to determine the value of innovative small and medium businesses, as expressed in the form of ventures companies, for the country’s economic developmentВ статье рассматриваются факторы, влияющие на позиции страны в международной экономике, затем на основе данных факторов, определяется роль и значение инноваций в современном мире. Определяется роль малого и среднего бизнеса в национальных экономиках. Рассматривается сущность и дается характеристика венчурных предприятий, а также их роль и перспективы в экономике страны. Цель исследования является раскрыть значение малого и среднего инновационного бизнеса, выраженного в форме венчурных предприятий, для экономического развития стран

Experimental assessment of immunoreactivity indices and effectiveness of pharmacotherapy schemes in surgical models of acute pancreatitis of various severity

The investigation was aimed at assessment of immunoreactivity in the experimental groups of animals and evaluation of effectiveness of different combinations of pharmacological drugs used in the surgical models for the treatment of acute pancreatitis (AP) of various degrees of severit

TP53-binding protein variants and breast cancer risk: a case-control study

INTRODUCTION: The TP53-binding protein (53BP1) has been shown to influence TP53-mediated transcriptional activation, thus playing a pivotal role in DNA damage signalling. Genetic aberrations in TP53 and in ATM and CHEK2 predispose to cancer. We have therefore examined the effects of 53BP1 single nucleotide polymorphisms (D353E, G412S, and K1136Q) and the novel 53BP1 6bp deletion (1347_1352delTATCCC) on breast cancer risk. METHODS: Allelic discrimination was performed to investigate the frequencies of 53BP1 D353E, G412S, and K1136Q and of 1347_1352delTATCCC in 353 patients with breast cancer and 960 control individuals. RESULTS: No significant association of 53BP1 D353E, G412S, or K1136Q with breast cancer risk was detected. 53BP1 1347_1352delTATCCC, leading to the loss of an isoleucine and a proline residue, showed a nonsignificant inverse association with breast cancer risk (odds ratio = 0.61, 95% confidence interval = 0.22 to 1.68, P = 0.34). CONCLUSION: The lack of association casts doubt on the putative effects of D353E, G412S, and K1136Q on breast cancer risk. Investigating a larger study cohort might elucidate the influence of the 6bp deletion 1347_1352delTATCCC. Studying the functional effect and the impact of this variant on the risk of other cancers may be revealing

Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer

浜松医科大学学位論文　医博第600号（平成23年3月16日