Statistical analysis of entropy correction from topological defects in Loop Black Holes

In this paper we discuss the entropy of quantum black holes in the LQG formalism when the number of punctures on the horizon is treated as a quantum hair, that is we compute the black hole entropy in the grand canonical (area) ensemble. The entropy is a function of both the average area and the average number of punctures and bears little resemblance to the Bekenstein-Hawking entropy. In the thermodynamic limit, both the "temperature" and the chemical potential can be shown to be functions only of the average area per puncture. At a fixed temperature, the average number of punctures becomes proportional to the average area and we recover the Bekenstein-Hawking area-entropy law to leading order provided that the Barbero-Immirzi parameter, $\gamma$, is appropriately fixed. This also relates the chemical potential to $\gamma$. We obtain a sub-leading correction, which differs in signature from that obtained in the microcanonical and canonical ensembles in its sign but agrees with earlier results in the grand canonical ensemble.Comment: 12 pages, no figures. Version to appear in Phys. Rev.

Government promoting communication tool in innovation development of companies

New management tools are required to enhance interaction between Russian companies and government agencies for innovation development. A major interactive tool are Government Relations (GR) communications promoting a new relationship model in terms of innovative system management. Interaction with the authorities is a major factor in innovation development, and the company’s excellent reputation in the eyes of the authorities is a key element for business success and implementation of innovations. The study provides an explanation of the notion of ‘Government Relations’ (GR) and examines various academic approaches to GR in modern economics. We investigated the reasons for the development of GR at its present stage. The article looks at several GR tools in Russia public Relations (PR), public-private partnership and corporate social responsibility. We analyzed differences between lobbying and GR and demonstrated that lobbying is one of the key components (active phase) of GR activity. Data are provided on activities of the GR departments of major corporations of the Russian Federation. Furthermore, we examined the characteristics of PR development in Russia and substantiated the need for the implementation of GR into Russian enterprises and for training of highly qualified GR managers in Russia.peer-reviewe

Family History of Cancer and Tobacco Exposure in Index Cases of Pancreatic Ductal Adenocarcinoma

Aim. To examine interaction between history of cancer in first-degree relatives and tobacco smoking in index patients of pancreatic adenocarcinoma. Methods. We carried out a case-control involving 113 patients with pancreatic adenocarcinoma and 110 controls over a 12-month period at the Freeman Hospital, Newcastle upon Tyne, UK. They were all administered a detailed tobacco exposure questionnaire and a family history questionnaire. We calculated cumulative tobacco exposure and risk for pancreas cancer. Results. Both smokers (OR 3.01 (95% CI: 1.73 to 5.24)) and those with a family history of malignancy (OR 1.98 (95% CI: 1.15–3.38)) were more likely to develop pancreatic cancer. Having more than one first-degree relative with cancer did not significantly further increase the risk of pancreatic cancer. Amongst pancreatic cancer cases, cumulative tobacco exposure was significantly decreased (P = .032) in the group of smokers (current and ex-smokers) who had a family history of malignancy [mean (SD): 30.00 (24.77) pack-years versus 44.69 (28.47) pack-years with no such history]. Conclusions. Individuals with a family history of malignancy are at an increased risk of pancreatic cancer. Furthermore, individuals with a family history of malignancy and who smoke appear to require a lesser degree of tobacco exposure for the development of pancreatic cancer

A Case of Emmonsiosis in an HIV-Infected Child

Opportunistic fungal infections can cause significant morbidity and mortality in immunocompromised patients. We describe a paediatric case of an unusual disseminated fungal infection. A three-year-old HIV-infected child with severe immunosuppression (CD4+ T-cell count 12 × 106/L) was admitted to hospital with pneumonia, gastroenteritis and herpes gingivostomatitis. Despite antibacterial and antiviral therapy, he experienced high fevers and developed an erythematous maculopapular rash and abdominal tenderness. The child’s condition progressively worsened during the admission. A thermally dimorphic fungus was cultured from bone marrow and identified as an Emmonsia species on DNA sequencing. The patient made a good recovery on amphotericin B deoxycholate and antiretroviral therapy. Itraconazole was continued for a minimum of 12 months, allowing for immune reconstitution to occur. This case is the first documented description of disseminated disease caused by a novel Emmonsia species in an HIV-infected child in South Africa

Plasma Brain-Derived Neurotrophic Factor Levels in Newborn Infants with Neonatal Abstinence Syndrome

Background: Brain-derived neurotrophic factor (BDNF) is a type of growth factor that promotes growth and survival of neurons. Fetal exposure to opiates can lead to postnatal withdrawal syndrome, which is referred as neonatal abstinence syndrome (NAS). Preclinical and clinical studies have shown an association between opiates exposure and alteration in BDNF expression in the brain and serum levels in adult. However, to date, there are no data available on the effects of opiate exposure on BDNF levels in infant who are exposed to opiates in utero and whether BDNF level may correlate with the severity of NAS. Objective: To compare plasma BDNF levels among NAS and non-NAS infants and to determine the correlation of BDNF levels and the severity of NAS. Methods: This is a prospective cohort study with no intervention involved. Infants ≥35 weeks of gestation were enrolled. BDNF level was measured using enzyme-linked immunosorbent assay technique from blood samples drawn within 48 h of life. The severity of NAS was determined by the length of hospital stay, number of medications required to treat NAS. Results: 67 infants were enrolled, 34 NAS and 33 non-NAS. Mean gestational age did not differ between the two groups. Mean birth weight of NAS infants was significantly lower than the non-NAS infants (3,070 ± 523 vs. 3,340 ± 459 g, p = 0.028). Mean BDNF level in NAS group was 252.2 ± 91.6 ng/ml, significantly higher than 211.3 ± 66.3 ng/ml in the non-NAS group (p = 0.04). There were no differences in BDNF levels between NAS infants that required one medication vs. more than one medication (254 ± 91 vs. 218 ± 106 ng/ml, p = 0.47). There was no correlation between the BDNF levels and length of hospital stay (p = 0.68) among NAS infants. Overall, there were no significant correlations between BDNF levels and NAS scores except at around 15 h after admission (correlation 0.35, p = 0.045). Conclusion: Plasma BDNF level was significantly increased in NAS infants during the first 48 h when compared to non-NAS infants. The correlations between plasma BDNF levels and the severity of NAS warrant further study. These results suggest that BDNF may play a neuromodulatory role during withdrawal after in utero opiate exposure

Development of brand-communications to promote real estate market companies

Recently the competition in the real estate market has significantly increased. Therefore, the application of brand-communication strategies makes it possible to create a unique set of elements and other components of a brand considering the consumer's demands and the quality and efficiency of the company's operations. The proficiency in the development of brand-communication strategies and their most optimal implementation in a company's operations will make the developer's brand stand out compared to the competition and help establish a relationship of trust with loyal consumers and the mass media

Classical and quantum: a conflict of interest

We highlight three conflicts between quantum theory and classical general relativity, which make it implausible that a quantum theory of gravity can be arrived at by quantising classical gravity. These conflicts are: quantum nonlocality and space-time structure; the problem of time in quantum theory; and the quantum measurement problem. We explain how these three aspects bear on each other, and how they point towards an underlying noncommutative geometry of space-time.Comment: 15 pages. Published in `Gravity and the quantum' [Essays in honour of Thanu Padmanabhan on the occasion of his sixtieth birthday] Eds. Jasjeet Singh Bagla and Sunu Engineer (Springer, 2017

Theoretical Issues of the Formation of the Industrial Policy of Enterprises

The present article specifies the basic principles and components of the social and economic policy of enterprises. Structuring of components enabled the authors to formulate the main directions according to their activity profile and to provide a more detailed definition of the industrial policy of enterprises. The authors showed the nature of the impact of the industrial policy on the industrial complex of enterprises, its importance and relevance; the main problems are also outlined. The specific ways and opportunities for the solution of these problems, formulated by the authors, made it possible to offer the scheme of the main components of the concept of the formation of the industrial policy at enterprises and to define the key purpose, which in turn made it possible to specify tasks, requirements and restrictions when forming the industrial policy of enterprises at the present stage. The research conducted in the present article and the concept of industrial policy offered by the authors are regarded as the instrument of strategic management, the corrective model of the management system of enterprises taking into account the opportunities for strategic development and the influence of sectoral and regional policy, as well as science, which confirms the relevance of this subject. Keywords: social economic policy, external and internal components, infrastructure, industrial complex, concept of formation. JEL Classifications: L52, L53, M1

Bound States of String Networks and D-branes

We show the existence of non-threshold bound states of (p, q) string networks and D3-branes, preserving 1/4 of the full type IIB supersymmetry, interpreted as string networks dissolved in D3-branes. We also write down the expression for the mass density of the system and discuss the extension of the construction to other Dp-branes. Differences in our construction of string networks with the ones interpreted as dyons in N=4 gauge theories are also pointed out.Comment: 11 pages, latex, minor modifications (version to appear in Phys. Rev. Lett.