495 research outputs found
Efficacy of an Adenoviral Vectored Multivalent Centralized Influenza Vaccine
Mice were immunized with Adenovirus expressing the H1-con, H2-con, H3-con and H5-con HA consensus genes in combination (multivalent) and compared to mice immunized with the traditional 2010–2011 FluZone and FluMist seasonal vaccines. Immunized mice were challenged with 10–100 MLD50 of H1N1, H3N1, H3N2 and H5N1 influenza viruses. The traditional vaccines induced robust levels of HA inhibition (HI) titers, but failed to protect against five different heterologous lethal influenza challenges. Conversely, the multivalent consensus vaccine (1 × 1010 virus particles (vp)/mouse) induced protective HI titers of ≥40 against 8 of 10 influenza viruses that represent a wide degree of divergence within the HA subtypes and protected 100% of mice from 8 of 9 lethal heterologous influenza virus challenges. The vaccine protection was dose dependent, in general, and a dose as low as 5 × 107 vp/ mouse still provided 100% survival against 7 of 9 lethal heterologous influenza challenges. These data indicate that very low doses of Adenovirus-vectored consensus vaccines induce superior levels of immunity against a wide divergence of influenza subtypes as compared to traditional vaccines. These doses are scalable and translatable to humans and may provide the foundation for complete and longlasting anti-influenza immunity
Penguin decays of B mesons
Penguin, or loop, decays of B mesons induce effective flavor-changing neutral
currents, which are forbidden at tree level in the Standard Model. These decays
give special insight into the CKM matrix and are sensitive to non-standard
model effects. In this review, we give a historical and theoretical
introduction to penguins and a description of the various types of penguin
processes: electromagnetic, electroweak, and gluonic. We review the
experimental searches for penguin decays, including the measurements of the
electromagnetic penguins b -> s gamma and B -> K* gamma and gluonic penguins B
-> K pi, B+ -> omega K+ and B -> eta' K, and their implications for the
Standard Model and New Physics. We conclude by exploring the future prospects
for penguin physics.Comment: 49 pages, LATEX, 30 embedded figures, submitted to Annual Reviews of
Nuclear and Particle Scienc
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Data-in-Place: Thinking through the Relations Between Data and Community
We present findings from a year-long engagement with a street and its community . The work is targeted at exploring how the production and use of data is bound up with place, both in terms of physical and social geography. We detail three strands of the project. First, we consider how residents have sought to curate existing data about the street in the form of an archive with physical and digital components. Second, we report endeavours to capture data about the street’s environment, especially of traffic moving through it. Third, we draw on the possibilities afforded by technologies for polling opinion. We reflect on how these engagements have: materialised distinctive relations between the community and their data; surfaced flows and contours of data , and spatial, temporal and social boundaries ;and enacted a multiplicity of ‘small worlds’. We consider how such a conceptualisation of data-in-place is relevant to the design of data technologies
Rare radiative B decays to orbitally excited K mesons
The exclusive rare radiative B meson decays to orbitally excited axial-vector
mesons K_1^*(1270), K_1(1400) and to the tensor meson K_2^*(1430) are
investigated in the framework of the relativistic quark model based on the
quasipotential approach in quantum field theory. These decays are considered
without employing the heavy quark expansion for the s quark. Instead the s
quark is treated to be light and the expansion in inverse powers of the large
recoil momentum of the final K^{**} meson is used to simplify calculations. It
is found that the ratio of the branching fractions of rare radiative B decays
to axial vector K^*_1(1270) and K_1(1400) mesons is significantly influenced by
relativistic effects. The obtained results for B decays to the tensor meson
K_2^*(1430) agree with recent experimental data from CLEO.Comment: 17 pages, revte
Hadronic B decays: Supersymmetric enhancement and a simple spectator model
Two aspects of hadronic B decays are investigated. Firstly, the
supersymmetric enhancement of hadronic b decays by gluino penguin processes is
studied through their effect on the Wilson coefficients of the effective
Hamiltonian. Secondly, hadronization of the final state quarks is studied
through a simple phase space spectator model.Comment: 24 pages, REVTEX, minor additional text and some references adde
Observation of the Dynamic Beta Effect at CESR with CLEO
Using the silicon strip detector of the CLEO experiment operating at the
Cornell Electron-positron Storage Ring (CESR), we have observed that the
horizontal size of the luminous region decreases in the presence of the
beam-beam interaction from what is expected without the beam-beam interaction.
The dependence on the bunch current agrees with the prediction of the dynamic
beta effect. This is the first direct observation of the effect.Comment: 9 page uuencoded postscript file, postscritp file also available
through http://w4.lns.cornell.edu/public/CLNS, submitted to Phys. Rev.
Study of Charmless Hadronic B Meson Decays to Pseudoscalar-Vector Final States
We report results of searches for charmless hadronic B meson decays to
pseudoscalar(pi^+-,K^+-,Pi^0 or Ks^0)-vector(Rho, K* or Omega) final states.
Using 9.7 million BBbar pairs collected with the CLEO detector, we report first
observation of B^- --> Pi^-Rho^0, B^0 --> Pi^+-Rho^-+ and B^- --> Pi^-Omega,
which are expected to be dominated by hadronic b --> u transitions. The
measured branching fractions are (10.4+3.3-3.4+-2.1)x10^-6,
(27.6+8.4-7.4+-4.2)x10^-6 and (11.3+3.3-2.9+-1.4)x10^-6, respectively.
Branching fraction upper limits are set for all the other decay modes
investigated.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
A Measurement of the Decay Asymmetry Parameters in \Xi_{c}^{0}\to \X^{-}\pi^{+}
Using the CLEO II detector at the Cornell Electron Storage Ring we have
measured the decay asymmetry parameter in the decay . We find , using the world average value of
we obtain . The physically allowed range of a decay
asymmetry parameter is . Our result prefers a negative value:
is at the 90% CL. The central value occupies the
middle of the theoretically expected range but is not yet precise enough to
choose between models.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Study of 3-prong Hadronic Decays with Charged Kaons
Using a sample of 4.7/fb integrated luminosity accumulated with the CLEO-II
detector at the Cornell Electron Storage Ring (CESR), we have measured the
branching fractions of the tau lepton into and relative to and relative to . The relative branching fractions are: (5.16+-0.20+-0.50)*,
(1.52+-0.14+-0.29)*, (2.54+-0.44+-0.39)* and at 95%
C.L., respectively. Coupled with additional experimental information, we use
our results to extract information on the structure of three-prong tau decays
to charged kaons.Comment: 16 pages postscript file also available through
http://w4.lns.cornell.edu/public/CLN
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