How Important of the Accuracy Sales Forecasting Method Against Sales Strategy Decision Making of the Mobile Phone Network Operator Company: a Case Study

This paper examines the accuracy of sales forecasting method that are important for decision making of sales strategy the mobile phone network operator company. Sales forecasting used to estimate company products sales for next year, so the company could make sales strategy plans and estimation an amount to be produced next year. Mobile phone network operator is one of un-seasonable products. The purpose of the paper is to compare, analyze, and giving a recommend of the best sales forecasting method to improve the mobile phone network operator company. Quantitative data were collected through published companies finnacial reports, articles, and journals which related with Supply Chain Management theory. The contribution this paper is providing the mobile phone network operator company to make successful sales strategy based from good sales forecasting method. Keywords – Sales Forecasting, Mobile Phone Network Operator Company, Sales Strategy, Forecasting Metho

Perancangan Buku Esai Fotografi Mengenai Gambang Semarang Art Company

Gambang Semarang merupakan kesenian khas Semarang yang memiliki daya tarik tersendiri melalui pertunjukan musik, tari, dan lawakan, dan sejak tahun 1930 telah dianggap sebagai ikon kota Semarang. Dalam perjalannya Gambang Semarang hampir punah dikarenakan tidak adanya proses regenerasi dan kurangnya pengetahuan masyarakat akan kesenian tersebut. Melalui sebuah buku esai fotografi tentang Gambang Semarang diharapkan mampu memberikan pengetahuan dan melahirkan kepedulian masyarakat terhadap seni budaya. Ke depannya, melalui buku esai ini Gambang Semarang semakin maju dan berkembang sehingga membawa dampak positif bagi masyarakat dan kota Semarang

Polygenis (Polygenis) platensis (Jordan & Rothschild) (Siphonaptera: Rhopalopsyllidae, Rhopalopsyllinae), um Novo Registro no Brasil

Polygenis (Polygenis) platensis s. l. (Jordan & Rothschild) is recorded for the first time from Brazil in the municipalities of Capão da Canoa, Tramandaí and Osório, RS. New host records for this flea include Ctenomys flamarioni (Travi) and Ctenomys minutus (De Blainville). Morphological variations were also observed among the flea specimens collected on the same species of host at the same municipality, evidencing some hybridization between the two subspecies and disabling the determination of the subspecific status. The number of known species of Brazilian Siphonaptera is now 60.Centro de Estudios Parasitológicos y de Vectore

Polygenis (Polygenis) platensis (Jordan & Rothschild) (Siphonaptera: Rhopalopsyllidae, Rhopalopsyllinae), um Novo Registro no Brasil

Polygenis (Polygenis) platensis s. l. (Jordan & Rothschild) is recorded for the first time from Brazil in the municipalities of Capão da Canoa, Tramandaí and Osório, RS. New host records for this flea include Ctenomys flamarioni (Travi) and Ctenomys minutus (De Blainville). Morphological variations were also observed among the flea specimens collected on the same species of host at the same municipality, evidencing some hybridization between the two subspecies and disabling the determination of the subspecific status. The number of known species of Brazilian Siphonaptera is now 60.Centro de Estudios Parasitológicos y de Vectore

The Phototoxicity of Fluvastatin, an HMG-CoA Reductase Inhibitor, Is Mediated by the formation of a Benzocarbazole-Like Photoproduct

In this paper, we have investigated the mechanism of phototoxicity of fluvastatin, an 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in human keratinocytes cell line NCTC-2544. Fluvastatin underwent rapid photodegradation upon Ultraviolet-A (UVA) irradiation in buffered aqueous solution as shown by the changes in absorption spectra. Interestingly, no isosbestic points were observed but only a fast appearance of a spectral change, indicative of the formation of a new chromophore. The isolation and characterization of the main photoproduct revealed the formation of a polycyclic compound with a benzocarbazole-like structure. This product was also evaluated for its phototoxic potential. Cell phototoxicity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide test after 72 h from the irradiation in the presence of fluvastatin. The results showed a reduction of the cell viability in a concentration and UVA dose-dependent manner. Surprisingly, the photoproduct showed a dramatic decrease of the cell viability that occurred at concentrations of an order of magnitude lower than the parent compound. Flow cytometric analysis indicated that fluvastatin and its main photoproduct induced principally necrosis as revealed by the large appearance of propidium iodide-positive cells and confirmed also by the rapid drop in cellular adenosine triphosphate levels. Interestingly, a rapid increase of intracellular calcium followed by an extensive cell lipid membrane peroxidation and a significant oxidation of model proteins were induced by fluvastatin and its photoproduct, suggesting that these compounds exerted their toxic effect mainly in the cellular membranes. On the basis of our results, the phototoxicity of fluvastatin may be mediated by the formation of benzocarbazole-like photoproduct that acts as strong photosensitizer

Analysis of the antibiotic resistance profiles in methicillin-sensitive s. Aureus pathotypes isolated on a commercial rabbit farm in Italy

The breeding of meat rabbits is an important sector in the livestock industry in Italy. The focus of this study was to describe the antibiotic resistance profile distribution among the Methicillin-sensitive Staphylococcus aureus isolated in a rabbit farm. From 400 animals of different ages and three farm workers, 96 randomly selected strains isolated from various anatomical sites and lesions were analysed. According to spa typing and the resistance profiles towards veterinary and human antibiotics, 26 pathotypes were identified. The highest resistance was observed against Tetracyclines (92.3%) and Macrolides (80.8%), while almost all were susceptible to Penicillins, according to the limited use of β-lactams on the farm. In total, 92.3% of pathotypes were multidrug resistant (MDRs). Two MDR pathotypes belonging to the t2802 spa type were isolated from both farmers and rabbits. Age categories harboured significantly different pathotypes (p = 0.019), while no association was found between pathotypes and lesions (p = 0.128) or sampling sites (p = 0.491). The antibiotic resistance was observed to increase with the time spent in the farm environment (age category). The selective pressure exerted by antibiotic use acted by giving advantage to more resistant strains rather than by lowering susceptibility to various drug categories within strains

Safety and efficacy of BAY 94–9027, an extended-half-life factor VIII, during minor surgical procedures in patients with severe haemophilia A

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