Secondary centres of economic activity in the East Midlands: final report

This report outlines the findings of a study of secondary centres of economic activity in the East Midlands. The study builds on previous work undertaken in the ‘GDP Growth in the East Midlands and Yorkshire and Humberside regions’ project by the Enterprise Research and Development Unit on behalf of emda and Yorkshire Forward

Attitude sensor

A device for controlling the attitude of a spacecraft is described. The device consists of two light sensors on a spacecraft that are mounted beneath a baffle which divides the light from a light source such as the sun or a star. The divided light reflects off of two reflective surfaces onto the two light sensors. When the spacecraft assumes its normal attitude, the baffle divides the light source into two equal parts, causing the two light sensors to produce equal outputs. When the light is equally detected, the stabilizing system is disconnected. Deviations from the normal attitude cause unequal distribution of the light source and energize the stabilizing system

Rurality, productivity and skills in the East Midlands: final report

This report sets out the findings of research into the relationship between rurality, skills and productivity in the East Midlands. The report has been prepared by the Enterprise Research and Development Unit (ERDU) at the University of Lincoln on behalf of the East Midlands Development Agency (emda)

Spitzer Observations of Gamma-Ray Burst Host Galaxies: A Unique Window into High Redshift Chemical Evolution and Star-formation

We present deep Spitzer 3.6 micron observations of three z~5 GRB host galaxies. Our observations reveal that z~5 GRB hosts are a factor of 3 less luminous than the median rest-frame V-band luminosity of spectroscopically confirmed z~5 galaxies in the GOODS fields and the UDF. The strong connection between GRBs and massive star formation implies that not all star-forming galaxies at these redshifts are currently being accounted for in deep surveys and GRBs provide a unique way to measure the contribution to the star-formation rate density from galaxies at the faint end of the galaxy luminosity function. By correlating the co-moving star-formation rate density with co-moving GRB rates at lower redshifts, we estimate a lower limit to the star-formation rate density of 0.12+/-0.09 and 0.09+/-0.05 M_sun/yr/Mpc^3 at z~4.5 and z~6, respectively. Finally, we provide evidence that the average metallicity of star-forming galaxies evolves as (stellar mass density)^(0.69+/-0.17) between $z\sim5$ and $z\sim0$, probably indicative of the loss of a significant fraction of metals to the intergalactic medium, particularly in low-mass galaxies.Comment: ApJ, in pres

A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK

BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c.118G > A in order to estimate the prevalence of the mutation in a referral population of GSD in the UK. RESULTS: This study demonstrated that the RFLP assay, based on use of PCR and subsequent digestion with the Eco571 enzyme, provided a simple genotyping test for the SOD1:c.118G > A mutation. In a young GSD population (i.e. dogs less than 6 years of age, before clinical signs of the disease usually become apparent), 8 of 50 dogs were found to be homozygous and a further 19 were heterozygous for the mutation. In dogs over 8 years of age, 21 of 50 dogs admitted to a tertiary referral hospital with pelvic limb ataxia as a major clinical sign were homozygous for the mutation, compared to none of 50 dogs of similar age, but where no neurological disease was reported on referral. CONCLUSIONS: This data suggests that genotyping for the SOD1:c.118G > A mutation is clinically applicable and that the mutation has a high degree of penetrance. Genotyping might also be useful for screening the GSD population to avoid mating of two carriers, but since the allele frequency is relatively high in the UK population of GSD, care should be taken to avoid reduction in genetic diversity within the breed

A New Concept for Controlled Lifting Entry Flight Experiments

Feasibility of trajectory guidance and control concept for lifting configuration with roll modulatio