Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications

One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and mortality in HIV-HCV coinfected individuals. Optimal treatment in this patient population is critical, as coinfection has been linked to deterioration of both disease states. The objective of this review article is to highlight the current literature on drug-drug interactions between HIV and HCV treatments. The management of the treatment of coinfection patients has been covered extensively in numerous other publications

On the relativistic iron line and soft excess in the Seyfert 1 galaxy Markarian 335

We report on a 133 ks XMM-Newton observation of the Seyfert 1 galaxy Markarian 335. The 0.4-12 keV spectrum contains an underlying power law continuum, a soft excess below 2 keV, and a double-peaked iron emission feature in the 6-7 keV range. We investigate the possibility that the double-peaked emission might represent the characteristic signature of the accretion disc. Detailed investigations show that a moderately broad, accretion disc line is most likely present, but that the peaks may be owing to narrower components from more distant material. The peaks at 6.4 and 7 keV can be identified, respectively, with the molecular torus in active galactic nucleus unification schemes, and very highly ionized, optically thin gas filling the torus. The X-ray variability spectra on both long (~100 ks) and short (~1 ks) timescales disfavour the recent suggestion that the soft excess is an artifact of variable, moderately ionized absorption.Comment: 6 pages, 2 figures, accepted for publication in MNRA

A Cutoff in the X-ray Fluctuation Power Density Spectrum of the Seyfert 1 Galaxy NGC 3516

During 1997 March-July, XTE observed the bright, strongly variable Seyfert 1 galaxy NGC 3516 once every ~12.8 hr for 4.5 months and nearly continuously (with interruptions due to SAA passage but not Earth occultation) for a 4.2 day period in the middle. These were followed by ongoing monitoring once every ~4.3 days. These data are used to construct the first well-determined X-ray fluctuation power density spectrum (PDS) of an active galaxy to span more than 4 decades of usable temporal frequency. The PDS shows no signs of any strict or quasi-periodicity, but does show a progressive flattening of the power-law slope from -1.74 at short time scales to -0.73 at longer time scales. This is the clearest observation to date of the long-predicted cutoff in the PDS. The characteristic variability time scale corresponding to this cutoff temporal frequency is 1 month. Although it is unclear how this time scale may be interpreted in terms of a physical size or process, there are several promising candidate models. The PDS appears similar to those seen for Galactic black hole candidates such as Cyg X-1, suggesting that these two classes of objects with very different luminosities and putative black hole masses (differing by more than a factor of 10^5) may have similar X-ray generation processes and structures.Comment: 21 pages, incl. 5 figures, AASTe

Evidence for Relativistic Outflows in Narrow-line Seyfert 1 Galaxies

We report the observation of features near 1 keV in the ASCA spectra from three ``Narrow Line Seyfert 1'' (NLS1) galaxies. We interpret these as oxygen absorption in a highly relativistic outflow. If interpreted as absorption edges, the implied velocities are 0.2--0.3c, near the limit predicted by ``line-locking'' radiative acceleration. If instead interpreted as broad absorption lines, the implied velocities are ~0.57c, interestingly near the velocity of particles in the last stable orbit around a Kerr black hole, although a physical interpretation of this is not obvious. The features are reminiscent of the UV absorption lines seen in broad absorption line quasars (BALQSOs), but with larger velocities, and we note the remarkable similarities in the optical emission line and broad band properties of NLS1s and low-ionization BALQSOs.Comment: 9 pages using (AASTeX) aaspp4.sty and 2 Postscript figures. Accepted for publication in Astrophysical Journal Letter

X-ray Surface Brightness Profiles of Active Galactic Nuclei in the Extended Groth Strip: Implications for AGN Feedback

Using data from the All Wavelength Extended Groth Strip International Survey (AEGIS) we statistically detect the extended X-ray emission in the interstellar medium (ISM)/intra-cluster medium (ICM) in both active and normal galaxies at 0.3 <= z <= 1.3. For both active galactic nuclei (AGN) host galaxy and normal galaxy samples that are matched in restframe color, luminosity, and redshift distribution, we tentatively detect excess X-ray emission at scales of 1--10 arcsec at a few sigma significance in the surface brightness profiles. The exact significance of this detection is sensitive to the true characterization of Chandra's point spread function. The observed excess in the surface brightness profiles is suggestive of lower extended emission in AGN hosts compared to normal galaxies. This is qualitatively similar to theoretical predictions of the X-ray surface brightness profile from AGN feedback models, where feedback from AGN is likely to evacuate the gas from the center of the galaxy/cluster. We propose that AGN that are intrinsically under-luminous in X-rays, but have equivalent bolometric luminosities to our sources will be the ideal sample to study more robustly the effect of AGN feedback on diffuse ISM/ICM gas.Comment: Accepted in PAS

AEGIS: Chandra Observation of DEEP2 Galaxy Groups and Clusters

We present a 200 ksec Chandra observation of seven spectroscopically selected, high redshift (0.75 < z < 1.03) galaxy groups and clusters discovered by the DEEP2 Galaxy Redshift Survey in the Extended Groth Strip (EGS). X-ray emission at the locations of these systems is consistent with background. The 3-sigma upper limits on the bolometric X-ray luminosities (L_X) of these systems put a strong constraint on the relation between L_X and the velocity dispersion of member galaxies sigma_gal at z~1; the DEEP2 systems have lower luminosity than would be predicted by the local relation. Our result is consistent with recent findings that at high redshift, optically selected clusters tend to be X-ray underluminous. A comparison with mock catalogs indicates that it is unlikely that this effect is entirely caused by a measurement bias between sigma_gal and the dark matter velocity dispersion. Physically, the DEEP2 systems may still be in the process of forming and hence not fully virialized, or they may be deficient in hot gas compared to local systems. We find only one possibly extended source in this Chandra field, which happens to lie outside the DEEP2 coverage.Comment: 5 pages, 3 figures. Accepted for publication in AEGIS ApJ Letters special editio

AEGIS: New Evidence Linking Active Galactic Nuclei to the Quenching of Star Formation

Utilizing Chandra X-ray observations in the All-wavelength Extended Groth Strip International Survey (AEGIS) we identify 241 X-ray selected Active Galactic Nuclei (AGNs, L > 10^{42} ergs/s) and study the properties of their host galaxies in the range 0.4 < z < 1.4. By making use of infrared photometry from Palomar Observatory and BRI imaging from the Canada-France-Hawaii Telescope, we estimate AGN host galaxy stellar masses and show that both stellar mass and photometric redshift estimates (where necessary) are robust to the possible contamination from AGNs in our X-ray selected sample. Accounting for the photometric and X-ray sensitivity limits of the survey, we construct the stellar mass function of X-ray selected AGN host galaxies and find that their abundance decreases by a factor of ~2 since z~1, but remains roughly flat as a function of stellar mass. We compare the abundance of AGN hosts to the rate of star formation quenching observed in the total galaxy population. If the timescale for X-ray detectable AGN activity is roughly 0.5-1 Gyr--as suggested by black hole demographics and recent simulations--then we deduce that the inferred AGN "trigger" rate matches the star formation quenching rate, suggesting a link between these phenomena. However, given the large range of nuclear accretion rates we infer for the most massive and red hosts, X-ray selected AGNs may not be directly responsible for quenching star formation.Comment: 12 pages. Submitted to ApJ. Comments welcom

The Ionized Gas and Nuclear Environment in NGC 3783 V. Variability and Modeling of the Intrinsic Ultraviolet Absorption

We present results on the location, physical conditions, and geometry of the outflow in the Seyfert 1 galaxy NGC 3783 from a study of the variable intrinsic UV absorption. Based on 18 observations with HST/STIS and 6 observations with FUSE, we find: 1) The absorption from the lowest-ionization species in each of the three strong kinematic components varied inversely with the continuum flux, indicating the ionization structure responded to changes in the photoionizing flux over the weekly timescales sampled by our observations. 2) A multi- component model with an unocculted NLR and separate BLR and continuum line-of-sight covering factors predicts saturation in several lines, consistent with the lack of observed variability. 3) Column densities for the individual metastable levels are measured from the resolved C III *1175 absorption complex observed in one component. Based on our computed metastable level populations, the electron density of this absorber is ~3x10^4 cm^-3. Photoionization modeling results place it at ~25 pc from the central source. 4) Using time-dependent calculations, we are able to reproduce the detailed variability observed in this absorber, and derive upper limits on the distances for the other components of 25-50 pc. 5) The ionization parameters derived for the higher ionization UV absorbers are consistent with the modeling results for the lowest-ionization X-ray component, but with smaller total column density. They have similar pressures as the three X-ray ionization components. These results are consistent with an inhomogeneous wind model for the outflow in NGC 3783. 6) Based on the predicted emission-line luminosities, global covering factor constraints, and distances derived for the UV absorbers, they may be identified with emission- line gas observed in the inner NLR of AGNs. (abridged)Comment: 30 pages, 18 figures (7 color), emulateapj, accepted for publication in The Astrophysical Journa

The Ionized Gas and Nuclear Environment in NGC 3783. I. Time-Averaged 900 ks Chandra Grating Spectroscopy

We present results from a 900 ks exposure of NGC 3783 with the High-Energy Transmission Grating Spectrometer on board the Chandra X-ray Observatory. The resulting X-ray spectrum has the best combination of signal-to-noise and resolution ever obtained for an AGN. This spectrum reveals absorption lines from H-like and He-like ions of N, O, Ne, Mg, Al, Si, and S. There are also possible absorption lines from H-like and He-like Ar and Ca. We also identify inner-shell absorption from lower-ionization ions such as Si_VII-Si_XII and S_XII-S_XIV. The iron absorption spectrum is very rich; L-shell lines of Fe_XVII-Fe_XXIV are detected, strong complex of M-shell lines, and probable resonance lines from Fe_XXV. The absorption lines are blueshifted relative to the systemic velocity by a mean velocity of -590+-150 km/s. We resolve many of the absorption lines, and their mean FWHM is 820+-280 km/s. We do not find correlations between the velocity shifts or the FWHMs with the ionization potentials of the ions. Most absorption lines show asymmetry, having more extended blue wings than red wings. In O_VII we have resolved this asymmetry to be from an additional absorption system at ~ -1300 km/s. The two X-ray absorption systems are consistent in velocity shift and FWHM with the ones identified in the UV lines of C IV, N V, and H I. Equivalent width measurements for all lines are given and column densities are calculated for several ions. We resolve the narrow Fe_K\alpha line at 6398.2+-3.3 eV to have a FWHM of 1720+-360 km/s, which suggests that this narrow line may be emitted from the outer part of the broad line region or the inner part of the torus. We also detect a `Compton shoulder' redward of the narrow Fe_K\alpha line which indicates that it arises in cold, Compton-thick gas.Comment: 19 pages, 12 figures (2 in color), emulateapj5, accepted for publication in The Astrophysical Journal Supplement