John Robert Eyer: Entomological Work in Pennsylvania and Lists of Publications

(excerpt) John Robert Eyer died at Carlsbad, New Mexico, on January 30, 1976. J. G. Watts and W. A. Iselin (1976), his former colleagues in the Department of Botany and Entomology at New Mexico State University, Las Cruces, wrote an obituary and quite naturally focused on Eyer\u27s work at the University\u27s Agricultural Experiment Station. Since Dr. Eyer\u27s first positions in entomology were in Pennsylvania, we have prepared this biographical sketch to preserve the record of his early accomplishments

BRIEF SYNTHESIS OF PRESENT INFORMATION ON THE GEOGRAPHICAL AND STRATIGRAPHICAL DISTRIBUTION OF FOSSIL FISH WITHIN THE STORMBERG SERIES, SOUTH AFRICA

A list is given of all specimens of Semionotus capensis Smith Woodward in South African collections. In addition a recent discovery of fish comparable with S. capensis in the Molteno Beds is recorded. This is the first true record of vertebrate life in this stage of the Stormberg Series, and if the identification can be confirmed, extends the record of this species in South Africa quite considerably.C.S.I.R., Pretori

Development of a soluble high-temperature insulation fibre

The three variables, dose, dimensions and durability, have been shown from many studies to be the factors that combine to give the potendal for a fibre to cause respiratory diseases. Considering durability, a fibre that could show increased dissoludon, possibly accompanied by chemical change, in physiological Solutions would be expected to show a reduced persistence in the lungs and have a lower potential for producing respiratory diseases. The development of such a fibre, Superwool X607, and the understanding that has been acquired in terms of solubility rate and other fibre properties is presented in this paper. The importance of in-vitro solubility rate studies to screen potendally useful fibre compositions, combined with an understanding of how these composidons can be selected using free energy of hydradon or non-bridging oxygen theories, is discussed in terms of developing new less "in-vivo" durable fibres

Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.

Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions between gene promoters and distal elements within target loci. In contrast, we demonstrate here that glucocorticoid addition to mouse bone-marrow-derived macrophages produces very rapid chromatin unfolding detectable by fluorescence in situ hybridization (FISH) at loci associated with GR binding. Rapid chromatin decompaction was generally not dependent on transcription at those loci that are known to be inducible in both mouse and human macrophages and was sustained for up to 5 days following ligand removal. Chromatin decompaction was not dependent upon persistent GR binding, which decayed fully after 24 hr. We suggest that sustained large-scale chromatin reorganization forms an important part of the response to glucocorticoid and might contribute to glucocorticoid sensitivity and resistance

Towards a competitive and sustainable OA market in Europe - A study of the open access market and policy environment

Deliverable 5.3 of OpenAIRE WP5: FP7 Post Grant Gold Open Access Pilot. This deliverable consists of a study and an annex - and it will be supplemented by a roadmap in May 2017. This study considers the economic factors contributing to the current state of the open-access publishing market, and evaluates the potential for European policymakers to enhance market competition and sustainability in parallel to increasing access. It was commissioned within the scope of the OpenAIRE FP7 Post-Grant Open Access Pilot, and it will be accompanied by a Roadmap document developed with inputs from an expert workshop to be held in The Hague on 20 April 2017. In accordance with the project brief, the study aims to: Explore the current status of the OA publishing market Analyse existing OA publishing business models Evaluate how different national and international policies are complementing each other as a means to achieve a transition to OA Evaluate the impact of the Framework Programme 7 Post-grant OA pilot and its implications for future similar initiatives and the transition to OA. Provide a roadmap leading to a sustainable and competitive market The transition to open access concerns all kinds of academic research outputs, including monographs, journal articles, and data. This study focuses on open access to peer-reviewed research articles, which constitute the bulk of the market and the primary mechanism through which research is disseminated across disciplinary communities and beyond. This report is supplemented by an Annex containing a mid-term evaluation of the FP7 Post-Grant Open Access Pilot.This report will be accompanied by a Roadmap document developed with inputs from an expert workshop to be held in The Hague on 20 April 201

Vascular phenotypes in primary non-small cell lung carcinomas and matched brain metastases

BACKGROUND: Anti-angiogenic therapy with bevacizumab (an anti-vascular endothelial growth factor (VEGF) antibody) predominantly targets immature blood vessels. Bevacizumab has shown a survival benefit in non-small cell lung carcinoma (NSCLC) and has recently been demonstrated to be safe in patients with brain metastases. However, it is not known whether bevacizumab is effective against brain metastases or whether metastases are representative of their primary in terms of VEGF expression, hypoxia, proliferation and vascular phenotype. The aim of this study was to evaluate these factors in a series of matched primary NSCLCs and brain metastases. METHODS AND RESULTS: Immunohistochemistry showed strong correlation of carbonic anhydrase 9 expression (a marker of hypoxia) in primary and secondary cancers (P=0.0002). However, the proliferation index, VEGF expression, microvessel density and the proportion of mature vessels were discordant between primary and secondary cancers. The mean proportion of mature vessels was 63.2% higher in the brain metastases than the primary tumours (P=0.004). Moreover, the vascular pattern of the primary tumour was not representative of the metastasis. CONCLUSIONS: Brain metastases have a significantly higher proportion of mature vasculature, suggesting that they may be refractory to anti-VEGF therapy. These findings may have implications for clinical trials and biomarker studies evaluating anti-angiogenic agents in brain metastases

Can Modus Vivendi Save Liberalism from Moralism? A Critical Assessment of John Gray’s Political Realism

This chapter assesses John Gray’s modus vivendi-based justification for liberalism. I argue that his approach is preferable to the more orthodox deontological or teleological justificatory strategies, at least because of the way it can deal with the problem of diversity. But then I show how that is not good news for liberalism, for grounding liberal political authority in a modus vivendi undermines liberalism’s aspiration to occupy a privileged normative position vis-à-vis other kinds of regimes. So modus vivendi can save liberalism from moralism, but at cost many liberals will not be prepared to pay