Fully automated operational modal analysis using multi-stage clustering

The interest for robust automatic modal parameter extraction techniques has increased significantly over the last years, together with the rising demand for continuous health monitoring of critical infrastructure like bridges, buildings and wind turbine blades. In this study a novel, multi-stage clustering approach for Automated Operational Modal Analysis (AOMA) is introduced. In contrast to existing approaches, the procedure works without any user-provided thresholds, is applicable within large system order ranges, can be used with very small sensor numbers and does not place any limitations on the damping ratio or the complexity of the system under investigation. The approach works with any parametric system identification algorithm that uses the system order n as sole parameter. Here a data-driven Stochastic Subspace Identification (SSI) method is used. Measurements from a wind tunnel investigation with a composite cantilever equipped with Fiber Bragg Grating Sensors (FBGSs) and piezoelectric sensors are used to assess the performance of the algorithm with a highly damped structure and low signal to noise ratio conditions. The proposed method was able to identify all physical system modes in the investigated frequency range from over 1000 individual datasets using FBGSs under challenging signal to noise ratio conditions and under better signal conditions but from only two sensors

Corrigendum to "Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung".

[This corrects the article DOI: 10.1155/2020/8506572.]

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

SummaryLymphocyte trafficking is critically regulated by the Sphingosine 1-phosphate receptor-1 (S1P1), a G protein-coupled receptor that has been highlighted as a promising therapeutic target in autoimmunity. Fingolimod (FTY720, Gilenya) is a S1P1 receptor agonist that has recently been approved for the treatment of multiple sclerosis (MS). Here, we report the discovery of NIBR-0213, a potent and selective S1P1 antagonist that induces long-lasting reduction of peripheral blood lymphocyte counts after oral dosing. NIBR-0213 showed comparable therapeutic efficacy to fingolimod in experimental autoimmune encephalomyelitis (EAE), a model of human MS. These data provide convincing evidence that S1P1 antagonists are effective in EAE. In addition, the profile of NIBR-0213 makes it an attractive candidate to further study the consequences of S1P1 receptor antagonism and to differentiate the effects from those of S1P1 agonists

Proton Acceleration by Io's Alfvénic Interaction

The Jovian Auroral Distributions Experiment aboard Juno observed accelerated proton populations connected to Io's footprint tail aurora. While accelerated electron populations have been previously linked with Io's auroral footprint tail aurora, we present new evidence for proton acceleration due to Io's Alfvénic interaction with Jupiter's magnetosphere. Separate populations were accelerated above the Io torus and at high latitudes near Jupiter. The timing suggests the acceleration is due to Alfvén waves associated with Io's Main Alfvén Wing. The inferred high-latitude proton acceleration region spans 0.92.5 Jovian radii in altitude, comparable to the expected location for electron acceleration, and suggests the associated Alfvén waves are able to accelerate electrons and protons in similar locations. The proton populations magnetically connected to Io's orbit are recently perturbed, equilibrating with the nominal torus plasma population on a timescale smaller than Io's System III orbital period of 13 h, likely due to wave-particle interactions. The tail populations are split into a wake-like structure with distinct inner and outer regions, where the inner region maps to an equatorial width nearly identical to the diameter of Io. The approximately symmetric surrounding outer regions are each slightly smaller than the central region and may be related to Io's atmospheric extent. The nominal, corotational torus proton population exhibits energization throughout all regions, peaking at the anti-Jovian flank of the inner core region mapping to Io's diameter. These proton observations suggest Alfvén waves are capable of accelerating protons in multiple locations and provide further evidence that Io's Alfvénic interaction is bifurcated

Trickraum: spacetricks

Trickfilme zeigen mit Vorliebe fantastische, paradoxe, ja unmögliche Orte, die wenig mit unserer gelebten Erfahrung der Welt gemeinsam haben. ‹Trickraum – Spacetricks› richtet den Blick auf das internationale Animationsfilmschaffen von heute und versammelt erstmals die Inspirationsquellen, Arbeitsprozesse und -materialien, die bei der Gestaltung innovativer Trickräume verwendet werden. Das reichhaltige Bildmaterial zeugt von den vielfältigen Arbeitstechniken der rund 25 vertretenen Filmemacherinnen und Filmemacher

Animated Wonderworlds / Animierte Wunderwelten Exhibition

Mythical creatures built of pixels inhabit fantastic worlds, flight simulators let us soar like birds and media facades transform entire buildings. Animated images like this are pervasive in our visual culture and define everyday life to such a degree that we hardly are aware of them. Hyperrealist feature films blur the boundaries between reality and fiction. Interactive applications like games or motion comics offer amazing bodily and spatial experiences. Animation also is used to give abstract data and information visual form and to make events at nanometer scale visible. The exhibition presents definitive works and the creative processes behind them, providing insights into the diverse worlds of animation in the digital era. The Museum für Gestaltung has presented a number of exhibitions on animation, including Animation – Der getrickte Film und seine Möglichkeiten (Animation: The Trick Film and Its Possibilities, 1972), and more recently Bewegte Schrift/ Type in Motion, which has been touring internationally since 2011. After to co-curation of Spacetricks (2005), in which co-curators Suzanne Buchan and Andres Janser focused on the profilmic materials used by contemporary animators to make their films, our current collaboration Animated Wonderworlds explores a set of themes in a heterogeneous selection of mainly digital and contemporary, often non-narrative animation, from data visualization and interactive apps to art, games, science, and consumer culture. The curatorial and editorial concept has a central aim: to enlighten visitors and readers about the origins and development of animation they encounter in everyday life. Animated Wonderworlds promotes interdisciplinary knowledge about animation design, production, distribution, and consumption. With its five thematic chapters of over 40 exhibit elements parenthesised by a photo essay, it encourages public interaction with a continuum of artworks, consumer goods, and moving images, allowing audiences to engage with ideas and artifacts simultaneously. They are complemented by Fischli (Fishies), a delightful, interactive “waterplay” with animation and sound, commissioned by the Museum für Gestaltung