The effects of climate change and variation in New Zealand: An assessment using the CLIMPACTS system

Along with a need to better understand the climate and biophysical systems of New Zealand, the need to develop an improved capacity for evaluating possible changes in climate and their effects on the New Zealand environment has been recognised. Since the middle of 1993 the CLIMPACTS programme, has been focused on the development of such a capacity, in the first instance for the agricultural sector. the goals of this present assessment are: 1. To present current knowledge on likely scenarios of climate change and associated uncertainties in New Zealand; 2. To present current knowledge, based on quantitative analyses using a consistent set of scenarios, on the likely effects of climate change on a range of agricultural and horticultural crops of economic importance; 3. To demonstrate, by way of this report and the associated technical report, the capacity that has been developed for ongoing assessments of this kind in New Zealand. This report has been prepared for both the science and policy communities in New Zealand. There are two main components: 1. The detailed findings of the assessment, presented in a series of chapters; 2. An annex, which contains technical details on models used in the assessment

An investigation of children's peer trust across culture: is the composition of peer trust universal?

The components of children's trust in same-gender peers (trust beliefs, ascribed trustworthiness, and dyadic reciprocal trust) were examined in samples of 8- to 11-year-olds from the UK, Italy, and Japan. Trust was assessed by children's ratings of the extent to which same-gender classmates kept promises and kept secrets. Social relations analyses confirmed that children from each country showed significant: (a) actor variance demonstrating reliable individual differences in trust beliefs, (b) partner variance demonstrating reliable individual differences in ascribed trustworthiness, and (c ) relationship variance demonstrating unique relationships between interaction partners. Cultural differences in trust beliefs and ascribed trustworthiness also emerged and these differences were attributed to the tendency for children from cultures that value societal goals to share personal information with the peer group

Towards mechanomagnetics in elastic crystals: insights from [Cu(acac)2_2]

We predict that the magnetic properties of \cuacac, an elastically flexible crystal, change dramatically when the crystal is bent. We find that unbent \cuacac\ is an almost perfect Tomonaga-Luttinger liquid. Broken-symmetry density functional calculations reveal that the magnetic exchange interactions along the chains is an order of magnitude larger than the interchain exchange. The geometrically frustrated interchain interactions cannot magnetically order the material at any experimentally accessible temperature. The ordering temperature ($T_N$), calculated from the chain random phase approximation, increases by approximately 24 orders of magnitude when the material is bent. We demonstrate that geometric frustration both suppresses $T_N$ and enhances the sensitivity of $T_N$ to bending. In \cuacac, $T_N$ is extremely sensitive to bending, but remains too low for practical applications, even when bent. Partially frustrated materials could achieve the balance of high $T_N$ and good sensitivity to bending required for practical applications of mechanomagnetic elastic crystals

The Trouble with the MDGs: Confronting Expectations of Aid and Development Success

The Millennium Development Goals (MDGs) are unlikely to be met by 2015, even if huge increases in development assistance materialize. The MDGs are a set of quantitative, time-bound targets for indicators such as poverty, education and mortality in developing countries adopted unanimously by the UN in 2000. However, the rates of progress required by many of the goals are at the edges of or beyond historical precedent. At the same time, there appear to be limits to the degree to which aid can contribute to development outcomes. Estimates of the ‘cost’ of reaching the MDGs are nevertheless frequently misinterpreted to mean that a certain quantity of aid—such as the oft-cited $50 billion—could cause the Goals to be met. Despite many benefits of the MDGs, there has been little discussion so far of potential costs of the specific form taken by these goals, especially the creation of unreasonable expectations about what is achievable in a short time frame and about the role of aid in the development process. Many countries making extraordinarily rapid progress on MDG indicators, due in large part to aid, will nonetheless not reach the MDGs. Unrealistic targets thus may turn successes into perceptions of failure, serving to undermine future constituencies for aid (in donors) and reform (in recipients). This would be unfortunate given the vital role of aid and reform in the development process and the need for long-term, sustained aid commitments. Though goal-setting can be useful, these particular goals might be better viewed not as practical targets but instead as valuable reminders of the stark contrast between the world we have and the world we want, and as a call to redouble our search for interventions to close the gap more rapidly.Millennium Development Goals (MDGs), development assistance

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence.

Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents. However, far less is known about the role for hypocretin transmission in regulating ongoing cocaine-taking behavior. Here, we investigated the effects of the selective Hcrt-R1 antagonist SB-334867 on cocaine intake, as measured by intravenous (IV) cocaine self-administration in rats. The stimulatory effects of cocaine on brain reward systems contribute to the establishment and maintenance of cocaine-taking behaviors. Therefore, we also assessed the effects of SB-334867 on the reward-enhancing properties of cocaine, as measured by cocaine-induced lowering of intracranial self-stimulation (ICSS) thresholds. Finally, to definitively establish a role for Hcrt-R1 in regulating cocaine intake, we assessed IV cocaine self-administration in Hcrt-R1 knockout mice. We found that SB-334867 (1-4 mg/kg) dose-dependently decreased cocaine (0.5 mg/kg/infusion) self-administration in rats but did not alter responding for food rewards under the same schedule of reinforcement. This suggests that SB-334867 decreased cocaine reinforcement without negatively impacting operant performance. SB-334867 (1-4 mg/kg) also dose-dependently attenuated the stimulatory effects of cocaine (10 mg/kg) on brain reward systems, as measured by reversal of cocaine-induced lowering of ICSS thresholds in rats. Finally, we found that Hcrt-R1 knockout mice self-administered far less cocaine than wildtype mice across the entire dose-response function. These data demonstrate that Hcrt-R1 play an important role in regulating the reinforcing and reward-enhancing properties of cocaine and suggest that hypocretin transmission is likely essential for establishing and maintaining the cocaine habit in human addicts

FIJICLIM description and users guide

The FIJICLIM prototype is based on PACCLIM which was developed by the International Global Change Institute (IGCI) as part of the Pacific Islands Climate Change Assistance Programme (PICCAP) executed by the South Pacific Regional Environment Programme (SPREP). Both FIJICLIM and PACCLIM build directly on a comparable model development for New Zealand, known as the CLIMPACTS system (Kenny et al., 1995, 1999; Warrick et al., 1996, 1999). The development of CLIMPACTS has been funded by the Foundation for Research Science and Technology since 1993. Its core components, which include a graphic user interface (GUI), a customised geographic information system (GIS), and data compression routines, have provided the basis for the development of FIJICLIM. The development of FIJICLIM is complementary to similar developments that have evolved from CLIMPACTS, for Bangladesh (BDCLIM), Australia (OZCLIM), and for training in climate change V&A assessment (VANDACLIM)

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs

It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis. Carbohydrate detection revealed that six of the adiponectin isoforms are glycosylated. The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D). These four lysines were found to be hydroxylated and subsequently glycosylated. The glycosides attached to each of these four hydroxylated lysines are possibly glucosylgalactosyl groups. Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines. These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.link_to_subscribed_fulltex

The relationship between various live animal scores/measurements and carcass classification for conformation and fatness with meat yield and distribution, and ultimate carcass value

End of project reportAccordingly, the primary objectives of the following study were to: (1) determine the relationship of live animal muscular and skeletal scores, ultrasonically scanned muscle and fat depth measurements of the m. longissimus dorsi, and carcass conformation and fat scores with kill-out proportion, carcass composition and value. (2) Specifically develop and test the accuracy of prediction equations for carcass meat, fat and bone proportions, derived from carcass conformation and fat scores, and develop prediction equations for total carcass composition from hind-quarter composition

Validation and Improvement of the Beef Production Sub-index in Ireland for Beef Cattle

End of project reportThe objectives of the following study were to: a. Quantify the effect of sire genetic merit for BCI on: 1. feed intake, growth and carcass traits of progeny managed under bull or steer beef production systems. 2. live animal scores, carcass composition and plasma hormone and metabolite concentrations in their progeny. b. Compare the progeny of : 1. Late-maturing beef with dairy breeds and 2. Charolais (CH), Limousin (LM), Simmental (SM) and Belgian Blue (BB) sires bred to beef suckler dams, for feed intake, blood hormones and metabolites, live animal measurements, carcass traits and carcass value in bull and steer production systems