Worldwide time and frequency synchronization by planned VLBI networks

Accurate baseline determinations and clock synchronization results obtained from the Quasar Patrol observations at X band with the Goldstone-Haystack baseline are presented. In addition, data from stations at Greenbank, West Virginia, and Onsala, Sweden were used. It was estimated that clock accuracy was on the order of 16 cm

Suprathermal electrons at Saturn's bow shock

The leading explanation for the origin of galactic cosmic rays is particle acceleration at the shocks surrounding young supernova remnants (SNRs), although crucial aspects of the acceleration process are unclear. The similar collisionless plasma shocks frequently encountered by spacecraft in the solar wind are generally far weaker (lower Mach number) than these SNR shocks. However, the Cassini spacecraft has shown that the shock standing in the solar wind sunward of Saturn (Saturn's bow shock) can occasionally reach this high-Mach number astrophysical regime. In this regime Cassini has provided the first in situ evidence for electron acceleration under quasi-parallel upstream magnetic conditions. Here we present the full picture of suprathermal electrons at Saturn's bow shock revealed by Cassini. The downstream thermal electron distribution is resolved in all data taken by the low-energy electron detector (CAPS-ELS, <28 keV) during shock crossings, but the higher energy channels were at (or close to) background. The high-energy electron detector (MIMI-LEMMS, >18 keV) measured a suprathermal electron signature at 31 of 508 crossings, where typically only the lowest energy channels (<100 keV) were above background. We show that these results are consistent with theory in which the "injection" of thermal electrons into an acceleration process involves interaction with whistler waves at the shock front, and becomes possible for all upstream magnetic field orientations at high Mach numbers like those of the strong shocks around young SNRs. A future dedicated study will analyze the rare crossings with evidence for relativistic electrons (up to ~1 MeV).Comment: 22 pages, 5 figures. Accepted for publication in Ap

Cassini CAPS-ELS observations of negative ions in Titan's ionosphere: trends of density with altitude

Observations with the Electron Spectrometer sensor of the Cassini Plasma Spectrometer (CAPS-ELS) have revealed the existence of negative ions in Titan's ionosphere. Negative ions are observed during encounters whenever the instrument points in the ram direction at altitudes 950–1400 km. Complex hydrocarbon and nitrile chemical processes are believed to take place which play a role in haze formation. The heaviest ions observed so far have masses up to 13,800 amu/q. Using data from 34 Titan encounters, we show for the first time negative ion density trends of different mass groups, including total densities, with altitude. We determine peak densities and the associated altitudes at which they are observed and the highest altitudes at which individual mass groups are found

The paralytic shellfish toxin profiles and global distribution of the dinoflagellate Alexandrium minutum Halim

A comprehensive review was undertaken of the distribution of the toxic dinoflagellate Alexandrium minutum Halim. The primary threat to humans caused by A. minutum is because of the production of paralytic shellfish toxins (PSTs) which can accumulate in seafood vectors, which if consumed lead to the human condition known as paralytic shellfish poisoning. Within this work it became apparent that the known global spread of this important species has increased, either due to range expansion, as a consequence of improved or novel investigation, or as a combination of these factors. Those populations of A. minutum capable of producing PSTs display a range of different toxin profiles with differing saxitoxin derivatives or differing proportions of common toxins being present. As yet no genetic basis for these differences in toxin productivity has been isolated although there are currently 4 recognised clades within the A. minutum species the two principle clades being the Pacific and the Global. A novel analysis of A. minutum toxin profiles was undertaken by applying K means clustering to PST profiles extracted from the literature. This analysis generated 5 distinctive clusters, each relating to a statistically separable toxin profile. Interestingly examples of each of the two major clades had representatives from different toxin profile clusters. This suggests further, currently undetermined genetic separation or relatedness between clades, as the differences in the ITS region of the ribosome upon which the clades are based, does not seem to be coupled to the specifics of the toxin profile. It also raises the possibility that there is an environmental driver for the differing toxin profiles, although profiles clustered geographically in some cases in others they were either cosmopolitan or spatially isolated. This new approach offers an additional tool with which to examine the relationships between populations and target further genetic research

SuperNeurons: Dynamic GPU Memory Management for Training Deep Neural Networks

Going deeper and wider in neural architectures improves the accuracy, while the limited GPU DRAM places an undesired restriction on the network design domain. Deep Learning (DL) practitioners either need change to less desired network architectures, or nontrivially dissect a network across multiGPUs. These distract DL practitioners from concentrating on their original machine learning tasks. We present SuperNeurons: a dynamic GPU memory scheduling runtime to enable the network training far beyond the GPU DRAM capacity. SuperNeurons features 3 memory optimizations, \textit{Liveness Analysis}, \textit{Unified Tensor Pool}, and \textit{Cost-Aware Recomputation}, all together they effectively reduce the network-wide peak memory usage down to the maximal memory usage among layers. We also address the performance issues in those memory saving techniques. Given the limited GPU DRAM, SuperNeurons not only provisions the necessary memory for the training, but also dynamically allocates the memory for convolution workspaces to achieve the high performance. Evaluations against Caffe, Torch, MXNet and TensorFlow have demonstrated that SuperNeurons trains at least 3.2432 deeper network than current ones with the leading performance. Particularly, SuperNeurons can train ResNet2500 that has $10^4$ basic network layers on a 12GB K40c.Comment: PPoPP '2018: 23nd ACM SIGPLAN Symposium on Principles and Practice of Parallel Programmin

Preventing human immunodeficiency virus infection among sexual assault survivors in Cape Town, South Africa: an observational study.

We describe 131 South African sexual assault survivors offered HIV post-exposure prophylaxis (PEP). While the median days completed was 27 (IQR 27, 28), 34% stopped PEP or missed doses. Controlling for baseline symptoms, PEP was not associated with symptoms (OR = 1.30, 95% CI = 0.66, 2.64). Factors associated with unprotected sex included prior unprotected sex (OR = 6.46, 95% CI = 3.04, 13.74), time since the assault (OR = 1.33, 95% CI = 1.12, 1.57) and age (OR = 1.30, 95% CI = 1.08, 1.57). Trauma counseling was protective (OR = 0.18, 95% CI = 0.05, 0.58). Four instances of seroconversion were observed by 6 months (risk = 3.7%, 95% CI = 1.0, 9.1). Proactive follow-up is necessary to increase the likelihood of PEP completion and address the mental health and HIV risk needs of survivors. Adherence interventions and targeted risk reduction counseling should be provided to minimize HIV acquisition

An evaluation of Paralytic Shellfish Toxin occurrence and magnitude around the UK coast since 2008; using chemotaxonomy to maximise routine monitoring data

A dedicated monitoring programme exists within the UK for the analysis of marine biotoxins of microalgal origin, in shellfish from classified production areas. For England, Wales and Scotland this is currently delivered by Cefas on behalf of the Food Standards Agency (FSA) and Food Standards Scotland (FSS). This monitoring programme tests for three groups of toxins, including the paralytic shellfish toxins (PSTs), using chemical analytical techniques, as well as identifying their causative organisms, using light microscopy. Although toxicity and toxin profile within shellfish from around the UK is well documented, since the implementation of chemical analytical testing, the underlying causative microalgal species remain undetermined in most areas. This is due to a lack of resource within the monitoring programme to perform definitive identification following light microscopy and a lack of specific research work confirming the toxin producers in all areas. Presented here is an analysis of PST shellfish toxicity data from the UK monitoring programme displaying trends in distribution and magnitude of PSTs in shellfish over the last 15 years of monitoring. Further to this, toxin profile data generated following the implementation of HPLC-FLD for monitoring PSTs is analysed. This PST toxin profile analysis is used to offer a possible proxy method for the identification of microalgal species by their differing PST toxin profile as presented in the literature. The possible distribution of causative organisms is evaluated using this chemotaxonomic technique to allow for targeted future work

A review of the global distribution of Alexandrium minutum (Dinophyceae) and comments on ecology and associated paralytic shellfish toxin profiles, with a focus on Northern Europe

Alexandrium minutum is a globally distributed harmful algal bloom species with many strains that are known to produce paralytic shellfish toxins (PSTs) and consequently represent a concern to human and ecosystem health. This review highlights that A. minutum typically occurs in sheltered locations, with cell growth occurring during periods of stable water conditions. Sediment characteristics are important in the persistence of this species within a location, with fine sediments providing cyst deposits for ongoing inoculation to the water column. Toxic strains of A. minutum do not produce a consistent toxin profile, different populations produce a range of PSTs in differing quantities. Novel cluster analysis of published A. minutum toxin profiles indicates five PST profile clusters globally. Some clusters are grouped geographically (Northern Europe) whilst others are widely spread. Isolates from Taiwan have a range of toxin profile clusters and this area appears to have the most diverse set of PST producing A. minutum populations. These toxin profiles indicate that within the UK there are two populations of A. minutum grouping with strains from Northern France and Southern Ireland. There is a degree of interconnectivity in this region due to oceanic circulation and a high level of shipping and recreational boating. Further research into the interrelationships between the A. minutum populations in this global region would be of value

Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.

A yearlong study was performed to examine the effect of antibiotic administration on the bacterial gut flora. Gram-negative facultative anaerobic bacteria were recovered from the feces of healthy adult volunteers administered amoxicillin, minocycline or placebo, and changes determined in antimicrobial resistance (AMR) gene carriage. Seventy percent of the 1039 facultative anaerobic isolates recovered were identified by MALDI-TOF as Escherichia coli. A microarray used to determine virulence and resistance gene carriage demonstrated that AMR genes were widespread in all administration groups, with the most common resistance genes being bla TEM, dfr, strB, tet(A), and tet(B). Following amoxicillin administration, an increase in the proportion of amoxicillin resistant E. coli and a three-fold increase in the levels of bla TEM gene carriage was observed, an effect not observed in the other two treatment groups. Detection of virulence genes, including stx1A, indicated not all E. coli were innocuous commensals. Approximately 150 E. coli collected from 6 participants were selected for pulse field gel electrophoresis (PFGE), and a subset used for characterisation of plasmids and Phenotypic Microarrays (PM). PFGE indicated some E. coli clones had persisted in volunteers for up to 1 year, while others were transient. Although there were no unique characteristics associated with plasmids from persistent or transient isolates, PM assays showed transient isolates had greater adaptability to a range of antiseptic biocides and tetracycline; characteristics which were lost in some, but not all persistent isolates. This study indicates healthy individuals carry bacteria harboring resistance to a variety of antibiotics and biocides in their intestinal tract. Antibiotic administration can have a temporary effect of selecting bacteria, showing co-resistance to multiple antibiotics, some of which can persist within the gut for up to 1 year